Der Einfluss der Paraaminobenzoesäure auf die Gonocide Wirkung der Sulfonamide im Kulturversuch

The Mode of Action of the Sulfonamides

“…Early cataphoretic studies indicated that Prontosil, but not SA, is adsorbed onto serum albumin and bacterial protein but not to globulin (239,257). Kimmig and Weselmann (119), also using the cataphoresis technique, confirmed the negative results with globulin, but found all the sulfonamides studied, which included Albucid, Neo-Uliron and SP, to be adsorbed onto serum albumin. That the combination is an adsorption was indicated by the finding that dissociation could be produced by the addition of animal charcoal.…”

Metabolite Antagonists.

“…The molecular inhibition ratio between sulfanilamide and PABA was found to be 23,000:1. (84,196,222,231,245,299,302,389,405,427,431) (405) demonstrated the roughly linear relationship between the concentrations of sulfonamides (sulfanilamide, sulfapyridine, and sulfathiazole) and the minimum concentration of PABA required to prevent their bacteriostatic action (figure 1). They also noted that the concentration of PABA required to reverse the sulfonamides was directly related to their antibacterial activity.…”

“…A number of sulfonamides, including a series of alkyl thiadiazoles, was investigated by Kimmig (196), who found that in every case their antigonococcal action was prevented by PABA. No antisulfonamide activity could be demonstrated in gonococcal cells.…”