Der Einflu� von Plasmodium cathemerium auf den Aminos�uregehalt und die Eizahl von Culex pipiens fatigans

Many infectious diseases of man are transmitted by arthropods. It is not known whether the carriers were primarily susceptible or insusceptible as the cycle first came into existence. Similarly so little is understood, why some arthropods are suitable vectors and other close relatives are not suitable. Only the hypothesis that the agents are original parasites and not at all commensals or symbionts can reasonably explain the evolution of the cycles. It is shown by means of numerous examples how the vector can be damaged by the parasite. Some organs of the vector might become unfunctional, the reproduction rate might be lowered and the vector itself may die. On the other hand the vector has at its disposal defence mechanisms which are according to our present point of view limited to the midgut barrier and the hemolymph reactions. Both components of the system, the vector and the parasite together are capable of change under the influence of the other. For example through the high mortality of the susceptible part of a vector population the resistant and the tolerant individuals will be selected. On the contrary harmful parasites cannot transmit their genetic information when their virulence is so high that the vector will suffer death. Due to this the parasites succumb to a selection pressure and only the careful treatment of the vector is rewarding. Besides this rough pattern of actions and reactions exists also the possibility of developing finer adjustments, with the "molecular mimikry" as a well known example.

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Der Umbau von radioaktivem Phenylalanin und Tyrosin in Malaria-infizierten Culex-Weibchen

Maier

Nassif‐Makki

1975

Z. F. Parasitenkunde

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1. Culex females are fed on C14-phenylalanine or C14-tyrosine in sugar solution. Autoradiographic studies on homogenated females 1 or 4 days after feeding, show that the labeled amino acids are metabolized on the first day and are not detectable on the fourth day. 2. After increase of the amino acid concentration by saturation of the sugar solution with the unlabeled amino acid, the labeled acid and its metabolites are visable over a longer period of time. 3. Phenylalanine is metabolized to tyrosine and at least four other substances. Radioactivity on the starting point of the chromatogram can be interpreted as incorporation of tyrosine into proteins. 4. After infection with Plasmodium cathemerium, and feeding of C14-phenylalanine C14-tyrosine is demonstable over a longer period.

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Der Einflu� von Plasmodium cathemerium auf den Aminos�uregehalt und die Eizahl von Culex pipiens fatigans

Cited by 7 publications

References 35 publications

Biology of Blood-Sucking Insects

Biology of Blood-Sucking Insects

Arthropodan vectors of human parasites: Their pathology and defence reactions

Der Umbau von radioaktivem Phenylalanin und Tyrosin in Malaria-infizierten Culex-Weibchen

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