Der Einflu� von Guanethidin und Bretylium auf die Freisetzung von Brenzcatechinaminen

Studies on the Mechanism of Positive Inotropic and Chronotropic Actions of Bretylium and Tyramine

“…Such a conclusion is substantiated by the work of different investigators [7,11] who have shown the release of catecholamines from the spleen and adrenal glands. Although changes in the catecholamine content of guinea pig atria were not detected after the addition of bretylium to the tissue bath, it was found that bretylium, like tyramine failed to produce the positive inotropic effects on the atria treated with cocaine or on the atria from animals pretreated with reserpine [3,9], Furthermore, the incubation of the atria from the reserpine-treated guinea pigs with norepinephrine was demon strated to restore the actions of both bretylium and tyramine [3,9], On the basis of these results, it was postulated that the mechanism of sympathomimetic action of bretylium is similar to that of tyramine.…”

The Effect of Amethocaine on Acetylcholine‐induced Depolarization and Catecholamine Secretion in the Adrenal Chromaffin Cell

“…There has been evidence for some time now that local anaesthetics have a depressant effect on secretory activity of the adrenal medulla evoked by various substances (Eichholtz & Roesch, 1949 ; Lecomte, 1953 ;Philippu & Schumann, 1962). The inhibitory effect of amethocaine on the secretory response of perfused gerbil adrenal glands to acetylcholine conforms to this general pattern.…”

“…Various local anaesthetics, including amethocaine, have been reported to suppress the secretory response of adrenal medullae of different species to several stimulant substances, among them the physiological secretagogue acetylcholine (Eichholtz & Roesch, 1949;Lecomte, 1953;Philippu & Schumann, 1962 control responses to acetylcholine in the absence of amethocaine. As can be seen from Table 1 amethocaine greatly reduced the response to acetylcholine in each of four experiments.…”