Der Einflu� des duodenogastrischen Refluxes auf das Epithel an der gastroenteralen Anastomose

Schlag, Peter M.; Meister, H; Feyerabend, F.; Merkle, P

doi:10.1007/bf01254075

Cited by 13 publications

(1 citation statement)

References 15 publications

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“…He found 6-25% carcinomas after carcinogen application, but none at all without carcinogen. Schlag and his coworkers [4] investigated the role of duodenogastric reflux in the development of carcinomas in the operated stomach, but they failed to find any carcinomas in spite of additional carcinogen application. Table 3.…”

Section: Discussionmentioning

confidence: 99%

Operation‐sequel carcinoma of the stomach. Experimental studies of surgical techniques with or without resection

et al. 1981

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Several etiopathogenetic factors responsible for carcinogenesis in the operated stomach have been proposed in the literature, but exact proof is still lacking. An experimental assay was planned to determine the pathogenetic roles of surgical trauma, of duodenogastric reflux, and of carcinogen application and its effects. Five different techniques of gastric surgery were performed on a collective of 466 Wistar rats: Billroth I resection, Billroth II resection, Billroth II plus gastroenterostomy with Roux-en-Y technique, Billroth II plus Braun's anastomosis, and gastroenterostomy without resection. Forty-two animals were left unoperated as controls. The appropriate date for autopsy was determined by general clinical observation and random endoscopic and radiologic examinations, and eventually fixed on the 56th postoperative week.Carcinomas developing in the resected stomach were found in animals with and without carcinogen exposure. The actual rate of carcinoma incidence was strongly dependent on the surgical procedure chosen for the respective group. The lowest carcinoma incidence (0%) was found in gastroenterostomy without Roux-en-Y anastomosis, the highest rate (70% without carcinogen, 50% with carcinogen application) in gastroenterostomy alone.Tumor development was found to be connected with alterations of the physiological environment induced by the surgical intervention; a direct association between duodenogastric reflux and tumorigenesis can be postulated. The results of the present study are interpreted with an emphasis on reflux-preventing techniques for gastric surgery that should be included in clinical routine.

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Section: Discussionmentioning

confidence: 99%

Operation‐sequel carcinoma of the stomach. Experimental studies of surgical techniques with or without resection

et al. 1981

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Effect of duodenogastric reflux on gastric mucosal proliferation after gastric surgery

Houghton

Mortensen

Williamson

1987

Journal of British Surgery

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The effect of duodenogastric reflux on cell proliferation and mucosal mass in the stomach was studied. Male Wistar rats (n = 118) were submitted to Polya partial gastrectomy, partial gastrectomy with Roux-en-Y diversion of bile, total duodenogastric reflux or handling of the stomach alone (sham operation). Following oral administration of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine for 6 months, animals were killed 6, 9 or 12 months postoperatively and their stomachs were examined for crypt cell production rate and mucosal DNA content. Compared with shams, crypt cell production rate was more than twice as high in the gastric remnant 12 months after Polya partial gastrectomy (P less than 0.001) and median DNA content was 31 per cent greater (P = 0.05). After total duodenogastric reflux, DNA content was 62 per cent greater than in shams (P = 0.02), while Roux-en-Y diversion reduced crypt cell production rate by 65 per cent (P less than 0.001). Only Polya gastrectomy increased the number of rats developing gastric carcinomas (9 versus 2 shams; P less than 0.05). Increased mucosal cell proliferation in rats with duodenogastric reflux may help to explain the development of gastric stump cancer.

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The Surgical Treatment of Carcinoma in the Operated Stomach

Langhans¹,

Heidl²

1989

Gastric Carcinoma

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Der Einflu� des duodenogastrischen Refluxes auf das Epithel an der gastroenteralen Anastomose

Cited by 13 publications

References 15 publications

Operation‐sequel carcinoma of the stomach. Experimental studies of surgical techniques with or without resection

Operation‐sequel carcinoma of the stomach. Experimental studies of surgical techniques with or without resection

Effect of duodenogastric reflux on gastric mucosal proliferation after gastric surgery

The Surgical Treatment of Carcinoma in the Operated Stomach

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