Der Effekt von Medazepam (Nobrium®) auf die Schlaf-Wachregulation und den Blutdruck von wachen, unnarkotisierten Katzen / The Effect of Medazepam (Nobrium®) on the Sleep-Wake Regulation and on the Blood Pressure of Alert, Non-Anesthetized Cats

Heinemann, H.; Stosiek, U; Hartmann, A.

doi:10.1007/978-3-662-39718-3_86

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“…Furthermore, the average percentage of sleep time rapidly increased from saline controls to a dose of 0.9 mg/kg of DZ and then decreased for doses of 1.2 and 1.5 mg/kg. Several studies reported similiar effects on SWS with CZ and medazepam (11,12), whereas others obtained a decrease in SWS with CZ (14,32). Lanoir and Killam (20) demonstrated increased wakeful ness during the first 6 h after DZ administered in doses ranging from 0.25 to 2.0 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Effects of Diazepam on Sleep, Temperature, 5-Hydroxyindoleacetic and Homovanillic Acids in Cisternal Cerebrospinal Fluid of Cats

Griauzde¹,

Chen²,

Radulovački³

1979

Pharmacology

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The effects of diazepam (DZ) (0.3–1.5 mg/kg, i.p.) on sleep, cisternal cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA), and rectal temperature of cats were examined. The results showed that administration of DZ produced a significant increase (p = 0.02) in slow-wave sleep (SWS) with a peak occurring at a dose of 0.9 mg/kg. Further increase in doses of DZ decreased SWS. DZ administration produced no change in paradoxical sleep, rectal temperature, 5-HIAA or HVA CSF levels. Lack of correlation between various doses of DZ, and 5-HIAA or HVA concentrations in the presence of an increased percentage of SWS suggests a possible mode of DZ action mediated through a mechanism independent of monoamines. Usually monoamines are associated with normal sleep.

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Section: Discussionmentioning

confidence: 99%