Der dexamethason-suppressions-test bei anorexia nervosa

Kuhs, H.; Mester, Horst

doi:10.1007/bf00381045

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…All the three anorexics in the study were well established on refeeding programmes, and thus were gaining weight when seen. There are reports that cortisol hypersecretion in anorexics occurs in the presence of weight loss (Kuhs & Mester, 1985). Table 2 shows that, ofthe 3 anorecxics included in the study, the two who had their cortisols collected were not hypersecreting, and were therefore comparable with the mixed diagnostic group.…”

Section: Methodological Issuesmentioning

confidence: 97%

Salivary Cortisol Hypersecretion in Juvenile Depression

Foreman

Goodyer

1988

Child Psychology Psychiatry

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Thirty depressed inpatients aged 7-16 yrs were compared for salivary hypercortisolism with a control group of 16 inpatients of mixed diagnosis matched for age and sex. Four cortisol samples were taken over a 48 hr period: 8 a.m. and 11 p.m. on the first day; then, with 1 mg of dexamethasone given immediately after the second sample, at 4 p.m. and 11 p.m. on the second day. All except the 8 a.m. value were significantly greater (P less than 0.03) in the depressed group. A 4 nmol/l cutoff for the 4 p.m. sample gave 48% sensitivity and 91% specificity for discriminating depressed cases (P = 0.03). The results indicate that the salivary method for estimating cortisol levels in children and adolescents with depression warrants further study.

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Section: Methodological Issuesmentioning

confidence: 97%

Salivary Cortisol Hypersecretion in Juvenile Depression

Foreman

Goodyer

1988

Child Psychology Psychiatry

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“…Moreover, the hyperactivity of the HPA axis differs in depression and AN, with a greater involvement of AVP in depressive disorder and perhaps more reliance on CRH to drive the axis in AN [98] . Some authors proposed malnutrition as the main determinant responsible for HPA axis alterations, because of the significant correlation between pathological DST results and the weight loss already mentioned [114][115][116][117] . Consistent with this interpretation is that the weight recovery is associated with a normalization of plasmatic and urinary cortisol levels [94,97] and with a significant decrease in the number of secretory bursts [97] .…”

Section: The Hpa Axis In the Specific Eating Disordersmentioning

confidence: 99%

Stress, Hypothalamic-Pituitary-Adrenal Axis and Eating Disorders

et al. 2008

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The etiopathogenesis of eating disorders (ED) is complex and poorly understood. Biological, psychological and environmental factors have all been considered to be involved in the onset and the persistence of these syndromes, often with conflicting results. The recent literature focused on the possible role of hormonal pathways, in particular the hypothalamic-pituitary-adrenal (HPA) axis, as a relevant factor capable of influencing the onset and the course of ED. Other studies have suggested that the onset of ED is often preceded by severe life events, and that chronic stress is associated with the persistence of these disorders. As the biological response to stress is the activation of the HPA axis, the available literature considering the relationships between stress, HPA axis functioning and anorexia nervosa, bulimia nervosa and binge eating disorder is reviewed by the present article.

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“…They are in this respect inconsistent with a close noso logical connection concerning anorexia ner vosa [9,22], obsessive-compulsive syn dromes or endogenous depression, because a significant correlate was found between pathological DST results and loss of weight, psychic and somatic stress and/or distur bance of biological rhythms.…”

Section: Neurobiological Aspectsmentioning

confidence: 60%

Syndrome Metamorphoses in Anorexia nervosa – An Example of Integrative Psychopathology

Böning

Kachel²

1990

Psychopathology

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In connection with the current knowledge of interdisciplinary results of research, we discuss clinical syndrome transitions of psychotic and non-psychotic quality in the course of anorexia nervosa. According to its internal and external conditions, anorexia nervosa can in principle occur in any person and in any phase of life during a critical trial situation as an ontologically given possibility of specific psychosomatic reaction. In the course of a mainly neurobiologically determined protopathic change of psychologically initiated cross-sectional psychopathology, very heterogenous secondary syndromes (impulsive, phobic, obsessive-compulsive, addictive, autoaggressive, depressive and schizophreniform) may facultatively become manifest. The similarity of such anorexia nervosa metamorphoses with classical nosological disease entities is likely to be based on a common disturbance of biological feedback systems. As a touchstone of classical ‘intermediate area’ in psychiatry the changing clinical picture of anorexia nervosa provokes a unitarian view of mental disease. It exemplifies a hesitant change of paradigm in an up till now dualistic conception of organic/biological and psychological models. This complementary approach tries to integrate psychic phenomena into a holistic understanding of complex psychopathological realities on the basis of qualitative and dimensional aspects in order to counteract the nowadays threatening loss of information in psychiatric phenomenology.

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Der dexamethason-suppressions-test bei anorexia nervosa

Cited by 4 publications

References 32 publications

Salivary Cortisol Hypersecretion in Juvenile Depression

Salivary Cortisol Hypersecretion in Juvenile Depression

Stress, Hypothalamic-Pituitary-Adrenal Axis and Eating Disorders

Syndrome Metamorphoses in Anorexia nervosa – An Example of Integrative Psychopathology

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