Der Boten-Ribonucleins�ure-Code von Escherichia coli A 19

The Evolution of the Vertebrate Neurohypophysial Hormones in Relation to the Genetic Code

“…The results of Khorana and co-workers (Soil et al 1965), Salas, Smith, Stanley, Jr., Wahba & Ochoa, (1965) and of Matthaei et al (1965), confirm in general the findings of Nirenberg, that all the possible codons have been ascribed to amino acids with two exceptions. Evidence is accumulating that the triplets UAA and UAG are 'nonsense' codons, i.e.…”

“…Recent advances in this field of study (Nirenberg, Leder, Brimacombe, Trupin, Rottman & O'Neil, 1965;Brimacombe, Trupin, Nirenberg, Leder, Bernfield & Jaouni, 1965;Soil, Ohtsuka, Jones, Lohrmann, Hayatsu, Nishimura & Khorana, 1965;Matthaei, Heller, Voigt, Kleinkauf, Küntzel, Vogt & Matthaei, 1965) have made the connexion between a defined codeword and an amino acid considerably less hypo¬ thetical. The substitution of one amino acid for another in a polypeptide chain may be the result of a single base change in the corresponding codeword.…”