Depth of invasion in patients with early stage oral cancer staged by sentinel node biopsy

Toom, Inne J den; Janssen, Luuk M.; Karagozoglu, K.H.; Keizer, Bart de; Weert, Stijn van; Willems, Stefan M.; Bloemena, Elisabeth; Leemans, C. René; Bree, Remco de

doi:10.1002/hed.25665

Cited by 31 publications

(20 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with a watchful waiting strategy of the neck were also included, which was not the case in the large ICOR study and the validation study by Matos et al . Recently, two other studies investigated the differences between the 7th edition and 8th edition TNM staging by using early‐stage OSCC patients . These studies differed from the current study by using sentinel lymph node biopsy (SLNB)‐staged patients or by analysing only the pT categories and not the pN categories.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early‐stage oral squamous cell carcinoma

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

“…This study shows that the 30 (15%) patients who were restaged as T3 would not have had an indication for an SLNB according to the 8th edition criteria. Den Toom et al . stated that 8th edition pT3 patients with tumours ≤40 mm in diameter probably benefit from staging of the neck with the SLNB procedure.…”

Section: Discussionmentioning

confidence: 99%

Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early‐stage oral squamous cell carcinoma

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Besides the diameter of the tumour reflected in pT stage in the 7th TNM classification, nowadays, the 8th edition is used [ 36 , 37 , 38 ]. In the 8th edition, depth of invasion is newly incorporated for T stage, and therefore, our results could not directly be translated to the 8th TNM classification [ 39 , 40 , 41 ]. Another important difference between both groups is the prolonged follow-up in the END cohort.…”

Section: Discussionmentioning

confidence: 99%

Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience

Toom

Boeve

Lobeek

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature. Methods: A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. Results: The overall sensitivity (84% vs. 81%, p = 0.612) and negative predictive value (NPV) (93%, p = 1.000) were comparable between END and SLNB patients. The END cohort contained more pT2 tumours (51%) compared to the SLNB cohort (23%) (p < 0.001). No differences were found for sensitivity and NPV between SLNB and END divided by pT stage. In floor-of-mouth (FOM) tumours, SLNB had a lower sensitivity (63% vs. 92%, p = 0.006) and NPV (90% vs. 97%, p = 0.057) compared to END. Higher disease-specific survival (DSS) rates were found for pT1 SLNB patients compared to pT1 END patients (96% vs. 90%, p = 0.048). Conclusion: In the absence of randomized clinical trials, this study provides the highest available evidence that, in oral cancer, SLNB is as accurate as END in detecting occult lymph node metastases, except for floor-of-mouth tumours.

show abstract

“…Two authors individually collected data from included articles in forms commensurate with each other. Diagnostic accuracy, represented by DOR, summary receiver operating characteristic (SROC) curve, and area under the curve (AUC), was calculated 1,5,11–102 . DOR was calculated as (true positive [TP]/false positive [FP])/(false negative [FN]/true negative [TN]) to assess diagnostic accuracy with 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Kim

et al. 2020

The Laryngoscope

View full text Add to dashboard Cite

Objective We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. Study Design A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. Methods Two reviewers individually searched the five databases up to November 2019. For studies that met inclusion criteria, data on patient diagnoses were pooled, including true positives, true negatives, false positives, and false negatives. Methodological quality was checked with the Quality Assessment of Diagnostic Accuracy Studies (version 2) tool. Results In total, 98 observational or retrospective studies were included. The diagnostic odds ratio of SLNB was 326.165 (95% confidence interval [CI]: 231.477–459.587; I2 = 0%). The area under the summary receiver operating characteristic curve was 0.982. Sensitivity was 0.827 (95% CI: 0.804–0.848), and specificity was 0.981 (95% CI: 0.975–0.986). The correlation between sensitivity and the false positive rate was −0.076, which indicates that heterogeneity did not exist. Subgroup analyses were performed with the subgroups reference test type, publication year, and study type. No significant difference was found within the reference test type subgroup. However, differences within the publication year and study type subgroups were significant, where the retrospective study subgroup was significantly more sensitive and specific than the prospective study subgroup. Conclusion Results of this meta‐analysis imply that the high specificity of SLNB supports its role as a diagnostic tool for patients with clinical tumor stage (CT)1‐2 clinically negative (N0) OSCC. More studies should be done to further verify the results of this study. Level of Evidence 2a Laryngoscope, 131:E459–E465, 2021

show abstract

Depth of invasion in patients with early stage oral cancer staged by sentinel node biopsy

Cited by 31 publications

References 47 publications

Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early‐stage oral squamous cell carcinoma

Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early‐stage oral squamous cell carcinoma

Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Contact Info

Product

Resources

About