Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

Bo, En; Luo, Yuting; Chen, Si; Liu, Xinyu; Wang, Nanshuo; Ge, Xin; Wang, Xianghong; Chen, Shufen; Chen, Shi; Li, Jinhan; Liu, Linbo

doi:10.1364/optica.4.000701

Cited by 59 publications

(40 citation statements)

References 18 publications

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“…To overcome the limitation in phase stability, synthetic aperture OCT has been developed and demonstrated to be effective in digitally correcting the spherical aberration of the focusing optics [20]. However, it divides the aperture central-symmetrically by wavefront [20] or sequentially by time [21,22] so that it is not possible to correct the sample-induced aberrations. In this study, we report a novel technique, termed amplitude division aperture synthesis optical coherence tomography (ADAS-OCT), which corrects both the sample-induced aberrations and spherical aberrations without any phase stability requirement.…”

Section: Introductionmentioning

confidence: 99%

Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction

Luo

et al. 2020

PhotoniX

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Noninvasive tomographic imaging of cellular processes in vivo may provide valuable cytological and histological information for disease diagnosis. However, such strategies are usually hampered by optical aberrations caused by the imaging system and tissue turbidity. State-of-the-art aberration correction methods require that the light signal be phase stable over the full-field data acquisition period, which is difficult to maintain during dynamic cellular processes in vivo. Here we show that any optical aberrations in the path length difference (OPD) domain can be corrected without the phase stability requirement based on maximum intensity assumption. Specifically, we demonstrate a novel optical tomographic technique, termed amplitude division aperture synthesis optical coherence tomography (ADAS-OCT), which corrects aberrations induced by turbid tissues by physical aperture synthesis and simultaneously data acquisition from sub-apertures. Even with just two subapertures, ADAS-OCT enabled in vivo visualization of red blood cells in human labial mucosa. We further demonstrated that adding sub-apertures could significantly scale up the aberration correction capability. This technology has the potential to impact a number of clinical areas where noninvasive examinations are preferred, such as blood count and cancers detection.

show abstract

Section: Introductionmentioning

confidence: 99%

Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction

Luo

et al. 2020

PhotoniX

Self Cite

View full text Add to dashboard Cite

show abstract

“…To overcome the limitation in phase stability, synthetic aperture OCT has been developed and demonstrated to be effective in digitally correcting the spherical aberration of the focusing optics [20]. However, it divides the aperture central-symmetrically by wavefront [20] or sequentially by time [21,22] so that it is not possible to correct the sample-induced aberrations. In this study, we report a novel technique, ADAS-OCT, which corrects both the sample-induced aberrations and spherical aberrations without any phase stability requirement.…”

Section: Introductionmentioning

confidence: 99%

Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction

Bo¹,

Ge²,

Luo³

et al. 2019

Preprint

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Noninvasive tomographic imaging of cellular processes in vivo may provide valuable cytological and histological information for disease diagnosis. However, such strategies are usually hampered by optical aberrations caused by the imaging system and tissue turbidity. State-of-the-art aberration correction methods require that the light signal be phase stable over the full-field data acquisition period, which is difficult to maintain during dynamic cellular processes in vivo. Here we show that any optical aberrations in the path length difference (OPD) domain can be corrected without the phase stability requirement based on maximum intensity assumption. Specifically, we demonstrate a novel optical tomographic technique, termed amplitude division aperture synthesis optical coherence tomography (ADAS-OCT), which corrects aberrations induced by turbid tissues by physical aperture synthesis and simultaneously data acquisition from sub-apertures. Even with just two sub-apertures, ADAS-OCT enabled in vivo visualization of red blood cells in human labial mucosa. We further demonstrated that adding sub-apertures could significantly scale up the aberration correction capability. This technology has the potential to impact a number of clinical areas where noninvasive examinations are preferred, such as blood count and cancers detection.

show abstract

“…However, an inherent challenge that comes with extended field‐of‐view is the limitation of system depth‐of‐focus (DOF) imposed by the Gaussian optics. For a conventional OCT imaging system with Gaussian detection beam, the image quality is only considered acceptable within the DOF, as defined by twice the Rayleigh length, expressed as DOF = 4λ/πNA , where NA stands for the numerical aperture of the objective lens. Given that the OCT lateral resolution is inversely proportional to the NA, the DOF can be considered proportional to the square of lateral resolution.…”

Section: Introductionmentioning

confidence: 99%

Flexible wide‐field optical micro‐angiography based on Fourier‐domain multiplexed dual‐beam swept source optical coherence tomography

Song

Wang

2017

Journal of Biophotonics

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Wide-field optical coherence tomography angiography (OCTA) is gaining interest in clinical imaging applications. In this pursuit, it is challenging to maintain the imaging resolution and sensitivity throughout the wide field of view (FoV). Here, we propose a novel method/system of dual-beam arrangement and Fourier-domain multiplexing to achieve wide-field OCTA when imaging the uneven surface samples. The proposed system provides 2 separate FoVs, with flexibility that the imaging area, focus of the imaging beam and imaging depth range can be individually adjusted for each FoV, leading to either (1) increased system imaging FoV or (2) capability of targeting 2 regions of interests that locate at depths with large difference between each other. We demonstrate this novel method by employing 100 kHz laser source in a swept source OCTA to achieve an effective 200 kHz sweeping rate, covering a 22 × 22 mm FoV. The results are verified by a SS-OCTA system employing a 200 kHz laser source, together with the experimental demonstrations when imaging whole brain vasculature in rodent models and skin blood perfusion in human fingers, show-casing the capability of proposed system to image live large samples with complex surface topography.

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Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

Cited by 59 publications

References 18 publications

Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction

Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction

Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction

Flexible wide‐field optical micro‐angiography based on Fourier‐domain multiplexed dual‐beam swept source optical coherence tomography

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