Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry

Abstract

Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myocardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats. Methods: Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system. Results: Intravenous administration of S miltiorrhiza depside salts resulted in a significant immediate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P<0.01 vs baseline) and 20.1%±3.5% (P<0.01), respectively. Myocardial microperfusion maximally increased by 6.3%±2.9% (P<0.01) and 9.6%±4.0% (P<0.01) for 30 mg/kg and 60 mg/kg S miltiorrhiza depside salts, respectively. Conclusion: These results indicated that S miltiorrhiza depside salts improved myocardial microperfusion, as well as CO.

Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway

“…Our previous studies indicated that MLB attenuated myocardial ischemia-reperfusion injury in Sprague-Dawley (SD) rats [15]. It remains unclear whether MLB can improve microcirculation dysfunction.…”

Salviaolate Protects Rat Brain from Ischemia-Reperfusion Injury through Inhibition of NADPH Oxidase

“…Among them, the antioxidative property of MLB is particularly impressive because its antioxidative effect is reported to be greater than that of α-lipoic acid [9], a super antioxidant available as a dietary supplement or pharmaceutical drug in many countries. MLB was able to reduce the size of myocardial infarction, suppress ischemia/reperfusion (I/R)-induced cardiomyocyte apoptosis, and improve myocardial microperfusion [10], which were related to, at least in part, its antioxidative activity [11]. In addition to the beneficial effects on the ischemic heart, MLB was also able to exert neuroprotective effects against ischemic strokes [12].…”

The effectiveness of Salvianolate injection for in-stent restenosis after percutaneous coronary intervention

“…It can also reduce the incidence of contrast-induced nephropathy after PCI and is more effective than normal saline [15] . In addition, it has been confirmed that intravenous administration of salvianolate can improve cardiac microcirculatory perfusion and increase cardiac output in rats [16] . Similarly, continuous intravenous salvianolate 10 mg/kg/day for 7 days can significantly improve myocardial microcirculatory reflow in an ischemia-reperfusion minipig model, as well as reduce oxidative stress and myocardial apoptosis [17] .…”

“…[ 15 ] In addition, it has been confirmed that intravenous administration of salvianolate can improve cardiac microcirculatory perfusion and increase cardiac output in rats. [ 16 ] Similarly, continuous intravenous salvianolate 10 mg/kg/day for 7 days can significantly improve myocardial microcirculatory reflow in an ischemia-reperfusion minipig model, as well as reduce oxidative stress and myocardial apoptosis. [ 17 ] However, there is no evidence to show the effectiveness of Salvianolate injection in the treatment of ISR.…”