Deprivation Amblyopia and Congenital Hereditary Cataract

Mansouri, Behzad; Stacy, Rebecca C.; Kruger, Joshua M.; Cestari, Dean M.

doi:10.3109/08820538.2013.825289

Cited by 17 publications

(11 citation statements)

References 67 publications

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“…There are reports regarding improvement in stereopsis following management of congenital cataract, management of monocular aphakia, or secondary lens implant. 4,[31][32][33][34][35][36] Similar results are found in the current study.…”

Section: Discussionsupporting

confidence: 91%

Does Improved Stereoacuity Lead to Retinal Structural Changes?

Shah¹,

Shah²,

Alane³

et al. 2016

J Pediatr Neurol

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Aim?To evaluate central macular thickness (CMT) following improved vision and stereoacuity in pediatric patients after medical intervention. Method?We enrolled children having refractive errors, squint, or cataract. Anterior and posterior segment examinations were done with stereoacuity evaluated. We subjected all eyes for Spectral domain optical coherence tomography (SD-OCT) and measured CMT. After appropriate treatment, stereoacuity and OCT were evaluated again after 3 months. Result?Here, we enrolled 229 children with mean age 10.6???4.5 and found significant improvement in vision and stereoacuity after treatment (p?

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Section: Discussionsupporting

confidence: 91%

Does Improved Stereoacuity Lead to Retinal Structural Changes?

Shah¹,

Shah²,

Alane³

et al. 2016

J Pediatr Neurol

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“…However, each year, millions of infants worldwide suffer from visual deprivation. These populations face the risk of irreversible amblyopia and numerous vision impairments [34][35][36]. Thus, it is important to investigate the mechanisms of environmental regulation of visual system development and its experience-dependent plasticity, which may provide further evidence to develop a comprehensive method for assessing the visual recovery potential in blind children.…”

Section: Discussionmentioning

confidence: 99%

Dynamic response to initial stage blindness in visual system development

et al. 2017

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Correspondence: Haotian Lin (gddlht@aliyun.com)Sensitive periods and experience-dependent plasticity have become core issues in visual system development. Converging evidence indicates that visual experience is an indispensable factor in establishing mature visual system circuitry during sensitive periods and the visual system exhibits substantial plasticity while facing deprivation. The mechanisms that underlie the environmental regulation of visual system development and plasticity are of great interest but need further exploration. Here, we investigated a unique sample of human infants who experienced initial stage blindness (beginning at birth and lasting for 2-8 months) before the removal of bilateral cataracts. Retinal thickness (RT), axial length (AL), refractive status, visual grating acuity and genetic integrity were recorded during the preoperative period or at surgery and then during follow-up. The results showed that the development of the retina is malleable and associated with external environmental influences. Our work supported that the retina might play critical roles in the development of the experience-dependent visual system and its malleability might partly contribute to the sensitive period plasticity.

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“…However, each year, millions of infants worldwide suffer from visual deprivation. These populations face the risk of irreversible amblyopia and numerous vision impairments (d' Almeida et al, 2013;Mansouri et al, 2013;. Thus, it is important to investigate the mechanisms of environmental regulation of visual system development and its experience-dependent plasticity, which may provide further evidence to develop a comprehensive method for assessing the visual recovery potential in blind children.…”

Section: Discussionmentioning

confidence: 99%