Depressive symptoms were a common risk factor for pre-frailty and frailty in patients with Alzheimer’s disease

Wu, Yu; Lee, Hsin Ning; Chang, Yu San; Wu, Chiu Hsiang; Wang, Chin Jen

doi:10.1016/j.archger.2020.104067

Cited by 11 publications

(27 citation statements)

References 40 publications

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“…Daily use of more than eight pills was consider as polypharmacy. Evaluation tools for frailty included (1) Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index (FRAIL model) [ 18 ]; (2) Cardiovascular Health Phenotypic Classification of Frailty index (CHS-PCF, Fried’s Frailty Phenotype) [ 19 ]; and (3) Study of Osteoporotic Fracture Index (SOF) [ 20 ]. All questionnaires were input into the computer twice by two independent personnel and the input correction was checked.…”

Section: Methodsmentioning

confidence: 99%

Polypharmacy Is Significantly and Positively Associated with the Frailty Status Assessed Using the 5-Item FRAIL Scale, Cardiovascular Health Phenotypic Classification of Frailty Index, and Study of Osteoporotic Fractures Scale

Hung

Yang

Lee

et al. 2021

JCM

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The aim of this study was to investigate the association between frailty and polypharmacy using three different frailty screening tools. This was a cross-sectional study of people aged ≥65 years. Participants were included and interviewed using questionnaires. Polypharmacy was defined as the daily use of eight or more pills. Frailty was assessed using a screening tool, including (1) the Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index (5-item FRAIL scale), (2) the Cardiovascular Health Phenotypic Classification of Frailty (CHS_PCF) index (Fried’s Frailty Phenotype), and (3) the Study of Osteoporotic Fracture (SOF) scale. A total of 205 participants (mean age: 71.1 years; 53.7% female) fulfilled our inclusion criteria. The proportion of patients with polypharmacy was 14.1%. After adjustments were made for comorbidity or potential confounders, polypharmacy was associated with frailty on the 5-item FRAIL scale (adjusted odds ratio [aOR]: 9.12; 95% confidence interval [CI]: 3.6–23.16), CHS_PCF index (aOR: 8.98; 95% CI: 2.51–32.11), and SOF scale (aOR: 6.10; 95% CI: 1.47–25.3). Polypharmacy was associated with frailty using three frailty screening tools. Future research is required to further enhance our understanding of the risk of frailty among older adults.

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Section: Methodsmentioning

confidence: 99%

Polypharmacy Is Significantly and Positively Associated with the Frailty Status Assessed Using the 5-Item FRAIL Scale, Cardiovascular Health Phenotypic Classification of Frailty Index, and Study of Osteoporotic Fractures Scale

Hung

Yang

Lee

et al. 2021

JCM

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“…Height and weight were measured with the participants wearing light clothing and no shoes, and body mass index (BMI, kg/m 2 ) was calculated. Serum levels of albumin, 25‐hydroxyvitamin D (25‐(OH)‐D), creatine and haemoglobin (Hb) were also evaluated as they are potential confounders for sarcopenia 22–25 . The simplified modification of diet in renal disease equation was used to calculate the estimated glomerular filtration rate (eGFR) from serum levels of creatinine 26 …”

Section: Methodsmentioning

confidence: 99%

Sarcopenia in female patients with Alzheimer's disease are more likely to have lower levels of haemoglobin and 25‐hydroxyvitamin D

Lee

Chang

et al. 2020

Psychogeriatrics

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Aim: Few studies have investigated sarcopenia in patients with cognitive impairment. However, identifying the characteristics and factors associated with sarcopenia in these patients may help to decrease the risk of falls, prevent disabilities, and maintain an independent life, all of which can affect the quality of life of both patient and caregiver. Therefore, the aim of this study was to investigate associated factors of sarcopenia in patients with mild to moderate Alzheimer's disease. Methods: This cross-sectional study enrolled 125 outpatients aged 65 to 89 years (mean age 79.5 AE 7.9 years) from January 2018 to December 2018. In addition to demographic characteristics, cognitive status, depressive mood, activities of daily living, body mass index (BMI), handgrip strength, gait speed, muscle mass, and serum levels of 25-hydroxyvitamin D (Vit D), haemoglobin (Hb), albumin and creatinine were assessed. Sarcopenia was defined based on the presence of low muscle mass and either low muscle strength or low physical performance. Results: Overall, 29.6% of the patients had sarcopenia. The patients with sarcopenia were mostly male, significantly older, and had a lower BMI and lower levels of Vit D. The female patients with sarcopenia were more likely to have lower levels of Hb. Multiple logistic regression showed that sarcopenia was associated with BMI in both genders. The level of Vit D was associated with sarcopenia in the female patients, whereas age was associated with sarcopenia in the male patients. Conclusions: A low BMI may be a dementia-related risk factor for sarcopenia. The female patients with sarcopenia were more likely to have lower levels of Hb and Vit D. There may be different risk profiles for sarcopenia in men and women with Alzheimer's disease. Further studies are needed to devise different nutritional support for muscle weakness in patients with cognitive decline by gender.

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“…A total of 24,617 older adults were included. The majority of studies were conducted in Asia, in China (Ge et al, 2020;Kwan et al, 2019), Taiwan (Li et al, 2020;Wu et al, 2020), Malaysia (Rivan et al, 2020;Rivan et al, 2019) and Japan (Shimada et al, 2016). One was conducted in the United States (Aliberti et al, 2019) and one in Mexico (Aguilar-Navarro et al, 2019).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Five studies used multiple assessments to establish that participants were cognitively impaired (Aguilar-Navarro et al, 2019;Kwan et al, 2019;Li et al, 2020;Rivan et al, 2020;Rivan et al, 2019). Assessments included the Mini-Mental State Examination (MMSE) (Folstein et al, 1975) (Aguilar-Navarro et al, 2019Kwan et al, 2019;Li et al, 2020;Rivan et al, 2020;Rivan et al, 2019;Wu et al, 2020); Short Portable Mental Status Questionnaire (SPMSQ) (Pfeiffer, 1975) (Ge et al, 2020); National Centre for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT) (Makizako et al, 2013) (Shimada et al, 2016); Rey Auditory Verbal Learning Test (RAVLT) (Schmidt, 1996) (Rivan et al, 2020;Rivan et al, 2019); Digit Span Forward and Backward test (Rivan et al, 2020;Rivan et al, 2019); neuropsychological evaluation in Spanish (NEUROPSI) (Ostrosky-Solís et al, 2007) (Aguilar-Navarro et al, 2019; Health Retirement Study (HRS) (Sonnega et al, 2014) validated assessment (Aliberti et al, 2019), diagnostic criteria such as Petersen criteria for MCI (Petersen, 2004) (Aguilar-Navarro et al, 2019Rivan et al, 2020;Rivan et al, 2019) and/or the Clinical Dementia Rating scale (Berg, 1984) (Aguilar-Navarro et al, 2019Kwan et al, 2019;Wu et al, 2020) and neuroimaging techniques Magnetic Resonance Imaging (MRI) (Aguilar-Navarro et al, 2019). Two studies adjusted cut-off points in line with the educatio...…”

Section: Measures Of Frailty and Cognitive Impairmentmentioning

confidence: 99%

Psychological and Social Factors Associated with Coexisting Frailty and Cognitive Impairment: A Systematic Review

2021

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Those living with coexistent frailty and cognitive impairment are at risk of poorer health outcomes. Research often focuses on identifying biological factors. This review sought to identify the association psychological and social factors have with coexisting physical and cognitive decline. Six databases were systematically searched in July 2020. Studies included individuals aged 60 years or older identified as being both frail and cognitively impaired. A narrative synthesis examined patterns within the data. Nine studies were included, most employed a cross-sectional design. Depression was investigated by all nine studies, those with coexistent frailty and cognitive impairment had higher levels of depressive symptoms than peers. Findings were mixed on social factors, although broadly indicate lower education, living alone and lower material wealth were more frequent in those living with coexistent decline. Further research is needed to explore potentially modifiable psychological and social factors which could lead to the development of supportive interventions.

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Depressive symptoms were a common risk factor for pre-frailty and frailty in patients with Alzheimer’s disease

Cited by 11 publications

References 40 publications

Polypharmacy Is Significantly and Positively Associated with the Frailty Status Assessed Using the 5-Item FRAIL Scale, Cardiovascular Health Phenotypic Classification of Frailty Index, and Study of Osteoporotic Fractures Scale

Polypharmacy Is Significantly and Positively Associated with the Frailty Status Assessed Using the 5-Item FRAIL Scale, Cardiovascular Health Phenotypic Classification of Frailty Index, and Study of Osteoporotic Fractures Scale

Sarcopenia in female patients with Alzheimer's disease are more likely to have lower levels of haemoglobin and 25‐hydroxyvitamin D

Psychological and Social Factors Associated with Coexisting Frailty and Cognitive Impairment: A Systematic Review

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