Depressive Symptoms, the Impact on ART Continuation, and Factors Associated with Symptom Improvement Among a Cohort of People Living with HIV in British Columbia, Canada

Pakhomova, Tatiana E.; Tam, Clara; Wang, Lu; Salters, Kate; Moore, David M.; Barath, Justin; Elterman, Simon; Dawydiuk, Nicole; Wesseling, Tim; Grieve, Sean; Sereda, Paul; Hogg, Robert; Barrios, Rolando

doi:10.1007/s10461-023-04156-3

Cited by 2 publications

References 54 publications

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The relationship between healthy lifestyles and cognitive function in Chinese older adults: the mediating effect of depressive symptoms

Xian,

Chai,

Gong

et al. 2024

BMC Geriatr

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Background Previous studies have proven the positive relationship between healthy lifestyles and cognitive function in older adults. However, the specific impacts and mechanisms require further investigation. Therefore, this study aimed to investigate whether healthy lifestyles and cognitive function were associated with Chinese older adults and whether depressive symptoms mediated their association. Methods 8272 valid samples were included using the latest data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Pearson’s test was applied to investigate the relationship between the key variables. Regression models were employed to examine the mediating effects of healthy lifestyles, using Sobel’s test and the bootstrap method to confirm path effects. Results There was a significant correlation between healthy lifestyles, depressive symptoms, and cognitive function (p < 0.01). Healthy lifestyles directly impact cognitive function (β = 0.162, p < 0.01). Healthy lifestyles had a significant effect on depressive symptoms (β=-0.301, p < 0.01), while depressive symptoms have a significant impact on cognitive function (β=-0.108, p < 0.01). Depressive symptoms partially mediated the effect of healthy lifestyles on cognitive function (β = 0.032, p < 0.01). The Sobel and bootstrap tests confirmed the robustness of the regression analysis results. Conclusion Depressive symptoms mediate the relationship between healthy lifestyles and cognitive function. Our findings suggest that prevention strategies for cognitive impairment in older adults should focus on healthy lifestyles and mental health.

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The relationship between healthy lifestyles and cognitive function in Chinese older adults: the mediating effect of depressive symptoms

Xian,

Chai,

Gong

et al. 2024

BMC Geriatr

View full text Add to dashboard Cite

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The association between multimorbidity patterns and physical frailty among middle-aged and older community-dwelling adults: The mediating role of depressive symptoms

Geng,

Zhou,

Liu

et al. 2024

Preprint

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Background: This study aimed to investigate the association between multimorbidity and frailty, and the potential mediating role of depressive symptoms in Chinese middle-aged and older community-dwelling adults. Methods: We selected a total of 5232 adults with two or more chronic diseases from the China Health and Retirement Longitudinal Study (CHARLS) database. Clusters of participants with similar multimorbidity patterns were identified through fuzzy c-means cluster analyses. The cross-sectional association between multimorbidity and frailty was measured through logistic regression analyses. Mediation analysis was applied to examine direct and indirect associations within the counterfactual framework. Results: At baseline, we identified five multimorbidity patterns. Two of these patterns significantly increased the risk of frailty compared to a non-specific pattern. Depression mediated 35.20% of the effect of multimorbidity on frailty (p = 0.042). Notably, in adults aged 60 years and older, this mediation accounted for 69.84% of the total effect, surpassing the direct impact of multimorbidity on frailty. Among individuals with economic support (0.020, 95% CI: 0.002-0.040), high school education (0.062, 95% CI: 0.007-0.120), and no alcohol consumption (0.024, 95% CI: 0.003-0.050), depression entirely mediated the impact of comorbidities. Conclusions: This study reveals strong links between specific multimorbidity patterns and physical frailty, with depression significantly mediating these effects, particularly in certain populations. Findings emphasize tailored mental health interventions' necessity in specific groups. Trial registration：The data was extracted from China Health and Retirement Longitudinal Study (CHARLS). The ethical approval number of CHARLS is IRB00001052-11015.

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Depressive Symptoms, the Impact on ART Continuation, and Factors Associated with Symptom Improvement Among a Cohort of People Living with HIV in British Columbia, Canada

Cited by 2 publications

References 54 publications

The relationship between healthy lifestyles and cognitive function in Chinese older adults: the mediating effect of depressive symptoms

The relationship between healthy lifestyles and cognitive function in Chinese older adults: the mediating effect of depressive symptoms

The association between multimorbidity patterns and physical frailty among middle-aged and older community-dwelling adults: The mediating role of depressive symptoms

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