Depressive Symptoms as Predictors of Mortality in Patients With COPD

Voogd, Jacob N. de; Wempe, Johan B.; Koëter, Gerard H.; Postema, Klaas; Sonderen, Eric van; Ranchor, Adelita V.; Coyne, James C.; Sanderman, Robbert

doi:10.1378/chest.08-0078

Cited by 162 publications

(125 citation statements)

References 49 publications

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“…All models included a strong association between age and mortality, which was in line with studies found in the literature [32,33,[35][36][37][38]. Validation against trial results also showed a difference in 12 mortality between young and old patients for the trial as well as most models.…”

Section: Discussionsupporting

confidence: 85%

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Patient Heterogeneity in Health Economic Decision Models for Chronic Obstructive Pulmonary Disease: Are Current Models Suitable to Evaluate Personalized Medicine?

et al. 2016

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Patient heterogeneity in health economic decision models for chronic obstructive pulmonary disease (COPD): are current models suitable to evaluate personalized medicine? 3 AbstractObjectives: To assess how suitable current COPD cost-effectiveness models are to evaluate personalized treatment options for COPD by exploring the type of heterogeneity included in current models and by validating outcomes for subgroups of patients.Methods: A consortium of COPD modelling groups completed three tasks. First, they reported all patient characteristics included in the model and provided the level of detail in which the input parameters were specified. Second, groups simulated disease progression, mortality, quality-adjusted life-years (QALYs) and costs for hypothetical subgroups of patients that differed in terms of gender, age, smoking status and lung function (FEV1% predicted). Finally, model outcomes for exacerbations and mortality for subgroups of patients were validated against published subgroup results of two large COPD trials.Results: Nine COPD modelling groups participated. Most models included gender (seven), age (nine), smoking status (six) and FEV1% predicted (nine), mainly to specify disease progression and mortality.Trial results showed higher exacerbation rates for females (found in one model), higher mortality rates for males (two models), lower mortality for younger patients (four models), and higher exacerbation and mortality rates in patients with severe COPD (four models).Conclusions: The majority of currently available COPD cost-effectiveness models are able to evaluate the cost-effectiveness of personalized treatment based on gender, age, smoking and FEV1% predicted. Treatment in COPD is however, more likely to be personalized based on clinical parameters. Two models include several clinical patient characteristics and are therefore most suitable to evaluate personalized treatment, although some important clinical parameters are still missing.4

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Section: Discussionsupporting

confidence: 85%

“…The difference in mortality is less clear from the literature. Some studies reported lower mortality rates for females [32][33][34], while others found no difference [35][36][37][38]. Only two models specified quality of life by gender, while several studies found a lower quality of life for female patients [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Patient Heterogeneity in Health Economic Decision Models for Chronic Obstructive Pulmonary Disease: Are Current Models Suitable to Evaluate Personalized Medicine?

et al. 2016

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“…41 Depressive symptoms are also an independent prognostic factor for all-cause mortality in stable COPD. 44 Primary care physicians may use additional help in the management of these symptoms, but options for best treatment are unclear. As with general depression and anxiety, these symptoms in COPD are managed using pharmacotherapy 45 and cognitive behavioural therapy, 46 although mixed results have been obtained with these approaches.…”

Section: Depressionmentioning

confidence: 99%

Co-morbidities of COPD in primary care: frequency, relation to COPD, and treatment consequences

Molena

2010

Primary Care Respiratory Journal

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Introduction: In the Western world, chronic obstructive pulmonary disease (COPD) is predominantly caused by long-term smoking, which results in pulmonary inflammation that is often associated with systemic inflammation. A number of co-morbid conditions, such as cardiovascular disease, muscle wasting, type 2 diabetes and asthma, may coexist with COPD; these and other co-morbidities not directly related to COPD are major causes of excess morbidity and mortality.

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“…5 Secondly, there appears to be greater disease burden, in terms of healthcare use and functional disability, in people with comorbid depression compared with those with physical health problems alone. 6,7 Thirdly, mortality is greater in several medical conditions when depression is presentheart disease, 8 COPD, 9 stroke, 10 cancer 11 -and in medically ill older adults. 12 Furthermore, morbidity and mortality may diminish with effective treatment of depression.…”

Section: Introductionmentioning

confidence: 99%

Case identification of depression in patients with chronic physical health problems: a diagnostic accuracy meta-analysis of 113 studies

Mitchell²,

et al. 2011

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Depressive Symptoms as Predictors of Mortality in Patients With COPD

Cited by 162 publications

References 49 publications

Patient Heterogeneity in Health Economic Decision Models for Chronic Obstructive Pulmonary Disease: Are Current Models Suitable to Evaluate Personalized Medicine?

Patient Heterogeneity in Health Economic Decision Models for Chronic Obstructive Pulmonary Disease: Are Current Models Suitable to Evaluate Personalized Medicine?

Co-morbidities of COPD in primary care: frequency, relation to COPD, and treatment consequences

Case identification of depression in patients with chronic physical health problems: a diagnostic accuracy meta-analysis of 113 studies

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