Depressive symptoms are associated with worsened severity of the metabolic syndrome in African American women independent of lifestyle factors: A consideration of mechanistic links from the Jackson heart study

Gurka, Matthew J.; Vishnu, Abhishek; Okereke, Olivia I.; Musani, Solomon K.; Sims, Mario; DeBoer, Mark D.

doi:10.1016/j.psyneuen.2016.02.030

Cited by 23 publications

(23 citation statements)

References 47 publications

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“…Poor baseline psychological health has been implicated in the onset and/or exacerbation of other health conditions such as hypertension 27 , metabolic syndrome 28 , CVD 29 , mild cognitive impairment 30 , and general pain 31 . However, in the present study, baseline wellbeing and depression were not significant predictors of pain change after 6 mo of ATORVA and do not appear to be associated with SAMS in otherwise healthy adults.…”

Section: Discussionmentioning

confidence: 99%

Influence of Baseline Psychological Health on Muscle Pain During Atorvastatin Treatment

et al. 2017

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Background HMG-CoA reductase inhibitors (statins) are generally well-tolerated, with statin-associated muscle symptoms (SAMS) the most common side effect (~10%) of statin users. However, studies and clinical observations indicate that many of the self-reported SAMS appear to be non-specific (i.e., not attributable to statins). Objective Mental health and wellbeing influences self-perception of pain, so we sought to assess the effect of baseline wellbeing and depression on the development of muscle pain with 6 mo of atorvastatin 80mg/d (ATORVA) or placebo in healthy, statin-naïve adults Methods The Psychological General Well-Being Index (PGWB; n=83) and Beck Depression Inventory (BDI; n=55) questionnaires were administered at baseline in participants (aged 59.5±1.2yr) from the STOMP trial (#NCT00609063). Muscle pain (Short-Form McGill Pain Questionnaire [SF-MPG]), pain that interferes with daily life (Brief Pain Inventory [BPI]), and pain severity (BPI) were then measured before, throughout, and after treatment. Results At baseline, there were no differences in wellbeing (PGWB), depression (BDI), or pain measures (SF-MPG and BPI) (ps≥0.05) between placebo and ATORVA groups. Baseline wellbeing correlated with baseline BPI pain severity (r=−0.290, p=0.008). Baseline depression correlated with baseline pain (SF-MPG; r=0.314, p=0.020). Baseline wellbeing and depression did not predict the change in pain severity or interference after 6 mo among the total sample or between groups (ps≥0.05). Conclusion Baseline wellbeing and depression were not significant predictors of pain after 6 mo of ATORVA (ps≥0.05). Thus, they do not appear to increase the risk of SAMS in otherwise healthy adults.

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Section: Discussionmentioning

confidence: 99%

Influence of Baseline Psychological Health on Muscle Pain During Atorvastatin Treatment

et al. 2017

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“…The potential mechanism might be related to its co-occurrence with obesity [6], as obesity is an important component of MetS and visceral adipose tissue secretes inflammatory cytokines that could cause chronic inflammation, and trigger MetS [7][8][9]. In addition, gender may be an effect modifier in the relationship between depression or depressive symptoms and MetS, even though studies reported inconsistent findings regarding the moderation effect of gender on the association between depression and MetS [10][11][12]. For example, a longitudinal study in Europe indicated that women Page 2 of 7 Liu et al Diabetol Metab Syndr (2020) 12:18 but not men with depressive symptoms are vulnerable to MetS [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, gender may be an effect modifier in the relationship between depression or depressive symptoms and MetS, even though studies reported inconsistent findings regarding the moderation effect of gender on the association between depression and MetS [10][11][12]. For example, a longitudinal study in Europe indicated that women Page 2 of 7 Liu et al Diabetol Metab Syndr (2020) 12:18 but not men with depressive symptoms are vulnerable to MetS [10,11]. On the contrary, a study from Japan found that the association only presented in men [12].…”

Section: Introductionmentioning

confidence: 99%

Depressive symptoms and metabolic syndrome components among older Chinese adults

Liu

Qian

Ma³

et al. 2020

Diabetol Metab Syndr

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Background: Few studies examined associations between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. Considering that the prevalence of depressive symptoms is high in older Chinese adults, we aimed to examine associations of depressive symptoms with MetS and its components in older Chinese adults.Methods: Data from a community-based cross-sectional study of 4579 Chinese adults aged 60 years or older were analyzed. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire. The presence of MetS was defined based on the Adult Treatment Panel III criteria, which include obesity, reduced blood high-density lipoprotein, high blood pressure (BP), elevated fasting plasma glucose and hypertriglyceridemia. A participant was considered as having MetS if he or she met at least three of the above-mentioned criteria.Results: In all participants, depressive symptoms were related to elevated fasting plasma glucose (≥ 7.0 mmol/L) (adjusted odds ratio [OR] = 1.50, 95% confidence interval [CI] [1.00-2.20]) and diabetes (adjusted OR = 1.50, 95% CI [1.01-2.20]). The associations of depressive symptoms with MetS and its components were not significant among women. However, there was a negative association between depressive symptoms and elevated systolic BP (≥ 130 mm Hg) (OR = 0.59, 95% CI [0.4-0.9]), and similar findings were observed after adjusting for lifestyle-related variables in men. Conclusions:In older Chinese adults, depressive symptoms were negatively associated with elevated systolic BP in men while these findings were not found in women.

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“…Depression is also considered to be significantly associated with Mets [10]. In previous studies, depression was observed as a critical risk factor for the development of Mets in middle-aged and older people [11,12].…”

Section: Introductionmentioning

confidence: 99%

Sex-based Association between Depression and Metabolic Syndrome in Korean Middle-aged and Older Adults

Suk

Kim

2017

Osong Public Health Res Perspect

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ObjectivesThis study aimed to identify the sex-based association between depression and the development of metabolic syndrome (Mets) among middle-aged and older Korean adults.MethodsA cross-sectional design was used for the secondary analysis of the 2010–2014 Korean National Health and Nutrition Examination Survey. Data from 1,938 men and 2,404 women were analyzed. Mets was defined in accordance with the criteria used for clinical diagnosis. Depression was assessed with a question about having clinical depression. The association between depression and the development of Mets with or without adjustment for covariates was identified by conducting logistic regression analysis on weighted data using a complex sample procedure.ResultsMore women than men had depression. Before covariate adjustment, depression was significantly associated with the development of Mets among women (odds ratio [OR], 1.586; 95% confidence interval [CI], 1.152–2.183) and with a higher triglyceride level among men (OR, 1.679; 95% CI, 1.001–2.818). After covariate adjustment; depression was significantly associated with higher waist circumference among women (adjusted OR [AOR], 1.532; 95% CI, 1.046–2.245) and higher triglyceride level (AOR, 1.511; 95% CI, 1.029–2.219) than was Mets. Conversely, depression did not have significant effects on the development of Mets among men.ConclusionDepression was associated with the development of Mets among middle-aged and older Korean women. Healthcare providers in communities should assess women with depression for the presence of Mets components. Interventions for relieving depressive symptoms should also be provided to women at risk for Mets.

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Depressive symptoms are associated with worsened severity of the metabolic syndrome in African American women independent of lifestyle factors: A consideration of mechanistic links from the Jackson heart study

Cited by 23 publications

References 47 publications

Influence of Baseline Psychological Health on Muscle Pain During Atorvastatin Treatment

Influence of Baseline Psychological Health on Muscle Pain During Atorvastatin Treatment

Depressive symptoms and metabolic syndrome components among older Chinese adults

Sex-based Association between Depression and Metabolic Syndrome in Korean Middle-aged and Older Adults

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