2002
DOI: 10.1176/appi.ajp.159.11.1862
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Depressive Symptoms and Severity of Illness in Multiple Sclerosis: Epidemiologic Study of a Large Community Sample

Abstract: In this large community sample, the severity of multiple sclerosis was more strongly associated with depressive symptoms than was pattern of illness. Clinicians should evaluate depression in patients with recent diagnoses of multiple sclerosis, major changes in functioning, or limited social support.

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Cited by 481 publications
(353 citation statements)
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“…[33] Reports of the lifetime risk for major depressive disorder (MDD) in MS populations have ranged from 27-54%. [32][33][34] The prevalence of clinically significant depressive symptoms is much higher [35] than the prevalence of major depressive disorder, but few studies have evaluated other depressive disorders such as dysthymia. [36] The depressive syndromes associated with MS occur throughout the natural history of the disease, including in patients with very mild forms of MS. [37] Some studies have found associations between depression and severity of MS as reflected by degree of disability [38], but other studies have not replicated these findings.…”
Section: Major Depressive Disorder Epidemiology and Clinical Corrmentioning
confidence: 99%
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“…[33] Reports of the lifetime risk for major depressive disorder (MDD) in MS populations have ranged from 27-54%. [32][33][34] The prevalence of clinically significant depressive symptoms is much higher [35] than the prevalence of major depressive disorder, but few studies have evaluated other depressive disorders such as dysthymia. [36] The depressive syndromes associated with MS occur throughout the natural history of the disease, including in patients with very mild forms of MS. [37] Some studies have found associations between depression and severity of MS as reflected by degree of disability [38], but other studies have not replicated these findings.…”
Section: Major Depressive Disorder Epidemiology and Clinical Corrmentioning
confidence: 99%
“…[36] The depressive syndromes associated with MS occur throughout the natural history of the disease, including in patients with very mild forms of MS. [37] Some studies have found associations between depression and severity of MS as reflected by degree of disability [38], but other studies have not replicated these findings. [33,39] The association of depression with the duration of MS illness is also unclear, with most studies finding no correlation [38][39], but others reporting a greater risk of depression in the first year after diagnosis [35] and in patients younger than 35. [40] Most studies have not found a correlation between depression and female gender among persons with MS. [35,[38][39] …”
Section: Major Depressive Disorder Epidemiology and Clinical Corrmentioning
confidence: 99%
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“…La SEP et la MP sont deux maladies neurologiques chroniques, invalidantes et stigmatisantes qui ont un impact physique et psychologique important sur la vie des patients. Par conséquent, de façon assez logique, la dépression est un symptôme majeur de la progression de la SEP et de la MP avec une prévalence autour de 20 à 50 % [4,21,34,40]. L'anxiété est de même assez couramment rencontrée dans la MP (environ 40 %) et la SEP (environ 35 %) [17,38] même si elle a été moins étudiée que la dépression.…”
Section: Introductionunclassified
“…1 Decreased quality of life and feelings of depression among individuals with MS are prevalent. [2][3][4] Reports of depressive symptoms such as "crying more" and having "pessimistic feelings about the future" confirm that elevated emotional distress is common. 5 This is further testimony to the extraordinary impact that MS can have on lifestyle, including maintaining, achieving, or just taking steps toward a balanced, satisfying, or lower-stress life.…”
mentioning
confidence: 99%