Depressive symptoms and inflammation among heart failure patients

Ferketich, Amy K.; Ferguson, Jeanette Pohorence; Binkley, Philip F.

doi:10.1016/j.ahj.2004.08.029

Cited by 84 publications

(72 citation statements)

References 34 publications

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“…88 Complex and not fully understood, depression is accompanied by moderate activation of proinflammatory cytokines, in particular TNF-α, IL-1, and IL-6. 89 Receptors for these cytokines have been found in the hippocampus and hypothalamus. Levels of TNF-α were significantly higher in outpatients with depression and heart failure than in outpatients with heart failure and no depression.…”

Section: Activation Of Cytokine Cascadesmentioning

confidence: 99%

“…88 In addition, levels of IL-6 were higher in patients with depression and heart failure who were hospitalized. 89 Cytokines can be also triggered by mental stress and are associated with anxiety and fear in healthy people without heart failure. 90 Administration of cytokines to patients can produce "sickness behavior," which is characterized by marked behavioral symptoms of depression and anxiety that include increased sleep, decreased appetite, malaise, decreased motivation, impairment in cognition, and depressed memory.…”

Section: Activation Of Cytokine Cascadesmentioning

confidence: 99%

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Pathophysiological Relationships Between Heart Failure and Depression and Anxiety

Chapa

Akintade

Son

et al. 2014

Critical Care Nurse

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H eart failure is an epidemic with national and global implications. Compared with the situation in other cardiac diseases, the incidence and prevalence of heart failure continue to increase despite recent advancements in understanding and treatment. Increased survival after myocardial infarction, aging of the population, and increased incidence of diabetes are contributing factors. This article has been designated for CNE credit. A closed-book, multiple-choice examination follows this article, which tests your knowledge of the following objectives:1. Describe the biopsychosocial holistic model for cardiovascular health 2. Identify 2 neurohormonal pathways and their impact in heart failure 3. Identify nursing implications for heart failure, depression, and anxiety CNE Continuing Nursing EducationCover Depression and anxiety are common comorbid conditions in patients with heart failure. Patients with heart failure and depression have increased mortality. The association of anxiety with increased mortality in patients with heart failure is not established. The purpose of this article is to illustrate the similarities of the underlying pathophysiology of heart failure, depression, and anxiety by using the Biopsychosocial Holistic Model of Cardiovascular Health. Depression and anxiety affect biological processes of cardiovascular function in patients with heart failure by altering neurohormonal function via activation of the hypothalamic-pituitary-adrenal axis, autonomic dysregulation, and activation of cytokine cascades and platelets. Patients with heart failure and depression or anxiety may exhibit a continued cycle of heart failure progression, increased depression, and increased anxiety. Understanding the underlying pathophysiological relationships in patients with heart failure who experience comorbid depression and/or anxiety is critical in order to implement appropriate treatments, educate patients and caregivers, and educate other health professionals. (Critical Care Nurse. 2014;34[2]:14-25)

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Section: Activation Of Cytokine Cascadesmentioning

confidence: 99%

Section: Activation Of Cytokine Cascadesmentioning

confidence: 99%

Pathophysiological Relationships Between Heart Failure and Depression and Anxiety

Chapa

Akintade

Son

et al. 2014

Critical Care Nurse

View full text Add to dashboard Cite

show abstract

“…HF and depression share common pathophysiological aspects, both increasing the stimulation of the hypothalamuspituitary-adrenal axis and the sympathetic activity, as well as increasing the levels of circulating inflammatory cytokines [14][15][16][17] . Depression can contribute to the development of HF in susceptible populations and aggravate the manifestations of HF in those with existing disease, and is predictive of rehospitalizations and mortality 6,7,10,11 .…”

mentioning

confidence: 99%

“…The high morbidity and mortality may be related to the synergistic action between HF and depression on neurohormonal activation; to inflammatory factors; and to hypercoagulability 5,14,15 . Depression also has a negative influence on the course of HF, for being associated with patient non-compliance with medical recommendations, especially as regards the use of medications [15][16][17] .…”

mentioning

confidence: 99%