Depressive Illness in a General Practice. A Demographic Study and a Controlled Trial of Imipramine

Porter, Alan

doi:10.1136/bmj.1.5699.773

Cited by 67 publications

(18 citation statements)

References 47 publications

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“…These disorders can cause considerable morbidity 2 3. Many patients with depressive disorders in primary care have a good outcome in the short term, but a significant proportion develop chronic illnesses 4 5. The treatment of depressive disorders in primary care has traditionally relied on drugs and reassurance,6 tricyclic antidepressants being more effective than placebo for patients with major depression 7 8 9 10.…”

Section: Introductionmentioning

confidence: 99%

Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care

Mynors-Wallis

Gath

Lloyd-Thomas

et al. 1995

BMJ

434

255

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Objective-To determine whether, in the treatment of major depression in primary care, a brief psychological treatment (problem solving) Results-At six and 12 weeks the difference in score on the Hamilton rating scale for depression between problem solving and placebo treatments was significant (5.3 (95% confidence interval 1-6 to 9.0) and 4-7 (0.4 to 9.0) respectively), but the difference between problem solving and amitriptyline was not significant (1-8 (-1l8 to 5.5) and 0 9 (-3.3 to 5.2) respectively). At 12 weeks 60%'/. (18/30) of patients given problem solving treatment had recovered on the Hamilton scale compared with 52% (16/31) given amitriptyline and 27% (8/30) given placebo. Patients were satisfied with problem solving treatment; all patients who completed treatment (28/30) rated the treatment as helpful or very helpful. The six sessions of problem solving treatment totalled a mean therapy time of31/, hours.Conclusions-As a treatment for major depression in primary care, problem solving treatment is effective, feasible, and acceptable to patients.

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Section: Introductionmentioning

confidence: 99%

Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care

Mynors-Wallis

Gath

Lloyd-Thomas

et al. 1995

BMJ

434

255

View full text Add to dashboard Cite

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“…This author proposed that marriage created additional strain for young women which may lead to psychiatric breakdown. Porter (98) studied depression in a general practice survey, and found that while depressive illness was rare in single women, married women seemed vulnerable. This finding was not age-related, but Porter found a considerable social class difference, with the wives of non-manual workers having a lesser vulnerability, and this is in accord with the findings of Brown and his colleagues in Camberwell.…”

Section: Transition To Parenthoodmentioning

confidence: 99%

Children and Marital Problems

Chester¹

1982

International Journal of Sociology and Social Policy

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If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.comEmerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services.Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Portico and the LOCKSS initiative for digital archive preservation.

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“…The results showed that both cognitive therapy and imipramine were effective, although no placebo-imipramine arm was included. One of the first placebo-controlled imipramine trials in a family doctor setting failed, however, to discriminate between active drug and placebo (Porter, 1970). On the other hand, a consequence of the Rush et al (1977) study was the gradual acceptance of imipramine for use even in patients with mild depression.…”

Section: Introductionmentioning

confidence: 99%

Is the antidepressive effect of second-generation antidepressants a myth?

Bech

2009

Psychol. Med.

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Two recent meta-analyses on second-generation antidepressants versus placebo in mild to moderate forms of major depression, based on data on all randomized clinical trials using the Hamilton Depression Scale (HAMD) submitted to FDA, have shown an effect size of y0.30 in favour of antidepressants in the acute therapy of major depression. The clinical significance of an effect size at this level was found to be so poor that these meta-analyses have subscribed to the myth of an exclusively placebo-like effect of second-generation antidepressants. A re-allocation of HAMD items focusing on those items measuring severity of clinical depression, the HAMD 6 , has identified effect sizes of o0.40 for second-generation antidepressants in placebo-controlled trials for which even a dose-response relationship can be demonstrated. In the relapse-prevention phase during continuation therapy of patients with major depression, the advantage of second-generation antidepressants over placebo was as significant as in the acute therapy phase. To explore a myth is not to deny the facts but rather to re-allocate them.

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Depressive Illness in a General Practice. A Demographic Study and a Controlled Trial of Imipramine

Cited by 67 publications

References 47 publications

Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care

Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care

Children and Marital Problems

Is the antidepressive effect of second-generation antidepressants a myth?

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