Abstract:In the cross-circulated canine heart-lung preparation,the stroke volume(SV)or the end-systolic volume increased linearly with increasing end-diastolic volume(EDV)when the afterloading impedance was fixed.Exactly the same result was obtained in the relation between the initial length(I)and the amount of shortening(S)for the tetanic contraction of isolated frog ventricular muscle.The slope of the EDV-SV or I-S relation was less than 1.0,suggesting that a kind of depressive effect or a deactivation of contraction… Show more
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