Depressive Disorders in Epilepsy

Kanner, Andrés M.; Nieto, Juan Carlos Rivas

doi:10.1002/9781118348093.ch11

Cited by 48 publications

(16 citation statements)

References 109 publications

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“…It has also been noted that 30-50% of epileptic patients reported with clinical depression [35,36]. Among 50 million PWE worldwide, 15-60% are also likely to experience any forms of depression or anxiety disorders, and 80% of those people are from a low economic status where these comorbidities remain concealed and thus untreated [37,38].…”

Section: Frequency Of Depression In Epilepsymentioning

confidence: 99%

A Comprehensive Review on Comorbid Depression in Patients With Epilepsy

Mammen

Kumar

2017

Asian J Pharm Clin Res

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Epilepsy is one of the common neurological disorders that are seen worldwide. It can also affect a person's social, mental, and physiological well-being and thus restricts and disables the common living of man. Depression as such has been well reported in patients with epilepsy, and also depression itself remains a factor that can lead to the development of epilepsy. Increased rates of suicidal tendencies are also associated with depression both in men and women. Depression is further extended in affecting the quality of life in epileptic patients. Depressive rates are found to have a higher value in epileptic patients when compared with the normal population. This article aims to produce a comprehensive review of the epidemiological considerations, clinical findings and management strategies for depression associated with epilepsy.

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Section: Frequency Of Depression In Epilepsymentioning

confidence: 99%

A Comprehensive Review on Comorbid Depression in Patients With Epilepsy

Mammen

Kumar

2017

Asian J Pharm Clin Res

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“…For example, over 50% of epileptic patients with depression have a family history of psychiatric illness (Kanner and Nieto, 1999;Robertson et al, 1987). One advantage of the SwLo rats as a model of epilepsy and depression comorbidity is that these animals have been selectively bred for over 50 generations and are genetically homogenous (Weinshenker et al, 2005; unpublished data).…”

Section: Potential Mechanisms Underlying the Swlo Seizure Phenotypesmentioning

confidence: 99%

Seizure Susceptibility and Epileptogenesis in a Rat Model of Epilepsy and Depression Co-Morbidity

Epps

Tabb

Lin

et al. 2012

Neuropsychopharmacol

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Although a strong co-morbidity exists clinically between epilepsy and depression, the cause of this co-morbidity remains unknown, and a valid animal model is crucial for the identification of underlying mechanisms and the development of a screening tool for novel therapies. Although some rodent models of epilepsy have been reported to display behaviors relevant to affective disorders, the seizure susceptibility of animals prone to depression-like behavior has not been characterized. Toward this end, we assessed several forms of seizure sensitivity and epileptogenesis in rats selectively bred for vulnerability (Swim Lo-Active; SwLo) or resilience (Swim High-Active; SwHi) to depression-like phenotypes. The SwLo rats exhibit decreased motor activity in a swim test and other depression-like phenotypes, whereas the SwHi rats display increased motor activity in a swim test. SwLo rats exhibited a decreased latency to limbic motor seizures following acute pilocarpine administration in the absence of differences in pilocarpine pharmacokinetics, and also had a decreased threshold to tonic seizures induced by electroshock. Approximately half of the SwLo rats, but none of the SwHi rats, had spontaneous limbic motor seizures 5 weeks following pilocarpine-induced status epilepticus. While the number of stimulations required to achieve full amygdala and hippocampal electrical kindling were similar in the two rat lines, SwLo rats had a lower final hippocampal kindling threshold and more wet dog shakes during both amygdala and hippocampal kindling. Combined, these results indicate that SwLo rats are a model of epilepsy and depression co-morbidity that can be used for investigating underlying neurobiological and genetic mechanisms and screening novel therapeutics.

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“…50,51 In geriatric patients, depression is probably the most common psychiatric illness and the aetiology is multifactorial. 51 The most frequently reported causes are social and occupational disability, limbic system dysfunction and genetic susceptibility.…”

Section: Neuropsychiatric Disorders In the Elderly Patients With Epilmentioning

confidence: 99%

Peculiarity of Epilepsy in Elderly People: A Review

Sanya¹

2011

West African Journal of Medicine

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BACKGROUND: Incidence of epilepsy in elderly patients is higher than in any other group. The diagnosis of epilepsy in old age is particularly challenging and is often overlooked or missed. Selection of appropriate antiepileptic drugs (AEDs) for this group of patient also requires more attention than younger patients. OBJECTIVE: To summarise the clinical presentation, aetiology, diagnosis, treatment, and neuropsychiatric complications of epilepsy in old age. METHODS: Systematic review of existing literature on epilepsy in the elderly was carried out using original articles, review articles, meta-analysis, case reports, standard neurology text and the Cochrane library data.

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Depressive Disorders in Epilepsy

Cited by 48 publications

References 109 publications

A Comprehensive Review on Comorbid Depression in Patients With Epilepsy

A Comprehensive Review on Comorbid Depression in Patients With Epilepsy

Seizure Susceptibility and Epileptogenesis in a Rat Model of Epilepsy and Depression Co-Morbidity

Peculiarity of Epilepsy in Elderly People: A Review

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