Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging

Lui, Su; Parkes, Laura M.; Huang, Xiaoqi; Zou, Ke; Chan, Raymond C.K.; Yang, Hong; Zou, Ling; Li, Dongming; Tang, Hehan; Zhang, Tijiang; Li, Xiuli; Wei, Yi; Chen, Long; Sun, Xiaochuan; Kemp, Graham J.; Gong, Qiyong

doi:10.1148/radiol.2512081548

Cited by 109 publications

(92 citation statements)

References 52 publications

(62 reference statements)

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“…Concomitantly, previous MRIbased perfusion studies in adults did not find rCBF differences between healthy controls and patients with MDD in this region. 37,54 In another report, only patients with poor treatment response exhibited hypoperfusion of the ACC, 36 indicating that lower cingulate blood flow may be associated with drug-related clinical outcomes. In accordance with our present findings, a recent transdiagnostic study reported lower ACC blood flow in adult patients with MDD than in healthy controls and patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…Nonmedi cated patients may present prefrontal hypoperfusion when measured with ASL. 33,36 Major depressive disorder has been repeatedly associated with brain volume change. 19,20,21,[22][23][24] Volume reduction of the ACC, as found in our medicated patient subsample, is a robust finding in patients with MDD.…”

Section: Discussionmentioning

confidence: 99%

“…Third, in patients with MDD we explored the association between rCBF and clinical features, such as the severity of depressive symptoms and the duration of illness, including the number of depressive episodes. Based on cerebral perfusion data in adolescent, 33 adult [34][35][36] and late-life depression 37 and on PET findings reporting metabolic changes in patients with MDD, we predicted that patients would exhibit abnormal lateral prefrontal, anterior cingulate and medial temporal rCBF compared with controls. Given that regions exhibiting abnormal neural activity and aberrant brain volume in patients with MDD may spatially overlap, we expected that correction for brain atrophy would also affect rCBF data.…”

Section: Introductionmentioning

confidence: 99%

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Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study

Vasić

Wolf

Grön

et al. 2015

J Psychiatry Neurosci

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IntroductionIn the past 2 decades, functional and structural neuroimaging techniques have been developing rapidly, yielding a large body of research addressing neural correlates of major depressive disorder (MDD). Neuroimaging has substantially shaped our understanding of depressive etiopathology, indicating its potential to become an objective tool of diagnostic, therapeutic and prognostic value.1 In MDD, first neuroimaging studies examined cerebral metabolism by means of positron emission tomography (PET). Predominantly left-sided decreased regional cerebral blood flow (rCBF) in the dorsolateral prefrontal cortex (DLPFC), medial prefrontal cortex (MPFC) and anterior cingulate cortex (ACC) were found.2,3 Comparing periods of acute illness with periods of recovery, remission of depressive symptoms was associated with a significant increase in rCBF in the left DLPFC cortical midline regions, such as the MPFC and ACC, suggesting state-relatedness of metabolic alterations. 4 Pretreatment metabolism in the rostral (pregenual) part of the ACC was reported to predict positive treatment response, 5-7 whereas hypermetabolism in the subcallosal part of the ACC was related to treatment resistance.8-11 Different treatment modalities have been shown to target distinct regions of the brain in patients with MDD. For instance, cognitive behavioural therapy was found to be associated with increased metabolism in the hippocampus and dorsal ACC together with metabolic decreases in prefrontal areas. In contrast, pharmacotherapy with paroxetine was related to prefrontal metabolism increases and subcortical decreases.12 Based on a rapidly growing body of neuroimaging evidence, specific neurobiological Background: Abnormal regional cerebral blood flow (rCBF) and grey matter volume have been frequently reported in patients with major depressive disorder (MDD). However, it is unclear to what extent structural and functional change co-occurs in patients with MDD and whether markers of neural activity, such as rCBF, can be predicted by structural change. Methods: Using MRI, we investigated resting-state rCBF and brain structure in patients with MDD and healthy controls between July 2008 and January 2013. We acquired perfusion images obtained with continuous arterial spin labelling, used voxel-based morphometry to assess grey matter volume and integrated biological parametric mapping analyses to investigate the impact of brain atrophy on rCBF. Results: We included 43 patients and 29 controls in our study. Frontotemporal grey matter volume was reduced in patients compared with controls. In patients, rCBF was reduced in the anterior cingulate and bilateral parahippocampal areas and increased in frontoparietal and striatal regions. These abnormalities were confirmed by analyses with brain volume as a covariate. In patients with MDD there were significant negative correlations between the extent of depressive symptoms and bilateral parahippocampal rCBF. We found a positive correlation between depressive symptoms and rCBF for right middle fron...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study

Vasić

Wolf

Grön

et al. 2015

J Psychiatry Neurosci

View full text Add to dashboard Cite

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“…The living quarters of all the participants were within 6.5 miles of our hospital, and all of them could keep in touch with their families by cell phone. Healthy controls were scanned for other studies 10,11 shortly (range 7-56, mean 41 [SD 14] d) before the earthquake.…”

Section: Discussionmentioning

confidence: 99%

“…They were recruited by poster advertisement, and they had undergone MRI for other studies 10,11 shortly before the earthquake. The following exclusion criteria applied to both groups: the existence of any neurologic or psychiatric disorder, any recent medications known to affect brain function, alcohol or drug abuse, pregnancy or any systemic physical illness, such as hepatitis or diabetes.…”

Section: Participantsmentioning

confidence: 99%

Brain structural plasticity in survivors of a major earthquake

Lui

Chen²,

Yao³

et al. 2013

J Psychiatry Neurosci

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Using arterial spin labeling to examine mood states in youth

et al. 2015

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IntroductionLittle is known about the neural correlates of mood states and the specific physiological changes associated with their valence and duration, especially in young people. Arterial spin labeling (ASL) imaging is particularly well-suited to study sustained cerebral states in young people, due to its robustness to low-frequency drift, excellent interscan reliability, and noninvasiveness. Yet, it has so far been underutilized for understanding the neural mechanisms underlying mood states in youth.MethodsIn this exploratory study, 21 healthy adolescents aged 16 to 18 took part in a mood induction experiment. Neutral, sad, and happy mood states were induced using film clips and explicit instructions. An ASL scan was obtained following presentation of each film clip.ResultsMood induction led to robust changes in self-reported mood ratings. Compared to neutral, sad mood was associated with increased regional cerebral blood flow (rCBF) in the left middle frontal gyrus and anterior prefrontal cortex, and decreased rCBF in the right middle frontal gyrus and the inferior parietal lobule. A decrease in self-reported mood from neutral to sad condition was associated with increased rCBF in the precuneus. Happy mood was associated with increased rCBF in medial frontal and cingulate gyri, the subgenual anterior cingulate cortex, and ventral striatum, and decreased rCBF in the inferior parietal lobule. The level of current self-reported depressive symptoms was negatively associated with rCBF change in the cerebellum and lingual gyrus following both sad and happy mood inductions.ConclusionsArterial spin labeling is sensitive to experimentally induced mood changes in healthy young people. The effects of happy mood on rCBF patterns were generally stronger than the effects of sad mood.

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Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging

Cited by 109 publications

References 52 publications

Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study

Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study

Brain structural plasticity in survivors of a major earthquake

Using arterial spin labeling to examine mood states in youth

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