Depressive disorder in patients with multiple sclerosis

Alajbegovic, Azra; Loga, Nataša; Tiro, Naida; Mehmedika-Suljić, Enra; Alajbegović, Salem

doi:10.1016/j.eurpsy.2007.01.741

Cited by 5 publications

(5 citation statements)

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“…Some authors [60,61] were unable to find significant correlations between the EDSS score and depressive scores. Most studies, however, found that MS patients with higher EDSS scores had significantly higher depression scores, while significant positive correlations were found between the EDSS and depression scores [62][63][64][65][66][67][68].…”

Section: Discussionmentioning

confidence: 93%

Immune-Inflammatory and Oxidative and Nitrosative Stress Biomarkers of Depression Symptoms in Subjects with Multiple Sclerosis: Increased Peripheral Inflammation but Less Acute Neuroinflammation

et al. 2015

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There is evidence that activated immune-inflammatory and oxidative and nitrosative stress (IO&NS) pathways play a role in the pathophysiology of multiple sclerosis (MS) and depression. This study examines serum levels of interleukin (IL)-1β, IL-4, IL-6, and IL-10; peroxides (LOOH); nitric oxide metabolites (NOx); albumin; ferritin; C-reactive protein (CRP); and tumor necrosis factor (TNF)-β NcoI polymorphism (rs909253) and gadolinium-enhanced magnetic resonance imaging (MRI) scan in MS patients with (n = 42) and without (n = 108) depression and normal controls (n = 249). Depression is scored using the depressive subscale of the Hospital Anxiety and Depression Scale (HADS). The extent of neurological disability is measured using the Expanded Disability Status Scale (EDSS) at the same time of the abovementioned measurements and 5 years earlier. Disease progression is assessed as actual EDSS-EDSS 5 years earlier. Three variables discriminate MS patients with depression from those without depression, i.e., increased IL-6 and lower IL-4 and albumin. Binary logistic regression showed that MS with depression (versus no depression) was characterized by more gastrointestinal symptoms and disease progression, higher serum IL-6, and lower albumin levels. In subjects with MS, the HADS score was significantly predicted by three EDSS symptoms, i.e., pyramidal, gastrointestinal, and visual symptoms. Fifty-eight percent of the variance in the HADS score was predicted by gastrointestinal symptoms, visual symptoms, the TNFB1/B2 genotype, and contrast enhancement (both inversely associated). There were no significant associations between depression in MS and type of MS, duration of illness, age, sex, nicotine dependence, and body mass index. MS with depression is associated with signs of peripheral inflammation, more disability, disease progression, gastrointestinal and visual symptoms, but less contrast enhancement as compared to MS without depression. It is concluded that depression is part of the neurological symptoms of MS and that its expression is primed by peripheral inflammation while acute neuroinflammation and the TNFB1/B2 genotype may be protective.

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Section: Discussionmentioning

confidence: 93%

Immune-Inflammatory and Oxidative and Nitrosative Stress Biomarkers of Depression Symptoms in Subjects with Multiple Sclerosis: Increased Peripheral Inflammation but Less Acute Neuroinflammation

et al. 2015

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“…[27][28][29] In cases of advanced MS, the most common psychological disorder reported is a reactive depression. 30 Chwastiak et al 31 also found that particularly those in the advanced stages of MS suffer more from depressive symptoms. Depression is thought to occur because of physical impairment, dependency on others as well as an uncertainty about their finances, job, and future.…”

Section: Discussionmentioning

confidence: 97%

Feeling severely affected by Multiple Sclerosis: What does this mean?

et al. 2011

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“…Treatment methods or psychological states of these systemic or chronic diseases can cause sexual dysfunction indirectly. In a study that contained 17 MS cases, psychiatric disorders were found in 12.56% [27] and in another study psychiatric disorders were found in 38% of patients with eosinophilic fasciitis [28]. Even though it is known that chronic diseases can cause psychiatric disorders by causing mood disorders, the number of studies that examine relations of these diseases with ED are limited.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of sexual dysfunction in male patients with migraine and tension type headache

et al. 2013

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BackgroundErectile dysfunction (ED), defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance, is a common condition. The psychological, hormonal, neurogenic and arterial pathologies, medications, chronic diseases have been reported in the etiology of the ED. This paper aims to study sexual dysfunction in the male patients with migraine and Tension type headache (TTH).Methods30 migraine cases (Group M), 31 TTH cases (Group T) and 30 control cases (Group C) were included in the study. Patients were evaluated with medical history, physical examination, body mass index (BMI), Beck Depression Inventory, biochemical analysis and hormone profiles. ED was evaluated via International Index of Erectile Function Scale (IIEF). In statistical analysis, variant analysis, post-hoc tukey test, Pearson correlation test, t-test, and fisher's exact chi-square test were used.ResultsThe patients' mean age was 34.96+/−1.30, 35.54+/−1.52 and 32.26+/−1.38 for group M,T and C, respectively. There was no significant difference between the groups in terms of testosterone levels. Mean IIEF scores was 19.83+/−2.2, 20.39+/−1.35 and 27.83+/−0.34 in groups M,T,C. When M and T groups were compared with group C, there were significant differences, and there was no statistical difference when T and M groups were compared to each other. Beck Depression Scores were not significantly different in groups M, T and C.ConclusionIn this study, it was shown that, migraine and TTH affects the sexual functions negatively in male patients. Chronic diseases may cause sexual disorders in patients because of despair, guilt, and fear of death or pain. Our results suggest that, along with the effect of chronic disease and pain, there must be other complicated factors exist causing the development of SD in patients with migraine and TTH.

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Depressive disorder in patients with multiple sclerosis

Cited by 5 publications

References 0 publications

Immune-Inflammatory and Oxidative and Nitrosative Stress Biomarkers of Depression Symptoms in Subjects with Multiple Sclerosis: Increased Peripheral Inflammation but Less Acute Neuroinflammation

Immune-Inflammatory and Oxidative and Nitrosative Stress Biomarkers of Depression Symptoms in Subjects with Multiple Sclerosis: Increased Peripheral Inflammation but Less Acute Neuroinflammation

Feeling severely affected by Multiple Sclerosis: What does this mean?

The evaluation of sexual dysfunction in male patients with migraine and tension type headache

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