Depressive Disorder and Incident Diabetes Mellitus: The Effect of Characteristics of Depression

Campayo, Antonio; Jonge, Peter de; Roy, Juan F.; Saz, Pedro; Cámara, Concepción de la; Quintanilla, Miguel; Marcos, Guillermo; Santabárbara, Javier; Lobo, Antonio

doi:10.1176/appi.ajp.2009.09010038

Cited by 165 publications

(114 citation statements)

References 34 publications

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“…Therefore, upregulated formation of KYN and 3-HK in depression in combination with P5P defi ciency might contribute to the increased association between depression and T2DM (Rustad et al 2011 ;Demakakos et al 2010 ) and increased (by 65 %) risk of development of T2DM (Campayo et al 2010 ) supporting the hypothesis that depression leads to diabetes (Eaton et al 1996 ).…”

Section: Dysregulation Of Trp-kyn Metabolism In Depressionmentioning

confidence: 73%

3-Hydroxykynurenic Acid and Type 2 Diabetes: Implications for Aging, Obesity, Depression, Parkinson’s Disease, and Schizophrenia

Oxenkrug

2015

Tryptophan Metabolism: Implications for Biological Processes, Health and Disease

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Aging, obesity, depression, Parkinson's and other neurodegenerative diseases, schizophrenia, and treatment with antipsychotic drugs are highly associated with insulin resistance (IR) and type 2 diabetes mellitus (T2D). Molecular mechanisms of increased associations remain uncertain. Current review of literature and our data suggest that one such mechanism is the overproduction of diabetogenic factors resulting from dysregulation of upstream and downstream pathways of tryptophan (TRP)-kynurenine (KYN) metabolism. Proinfl ammatory factors and stress hormones activate two upstream steps of TRP-KYN pathway: TRP conversion into KYN, a substrate for formation of kynurenic acid (KYNA), and KYN conversion into 3-hydroxyKYN (3-HK). The fi rst step of downstream pathway of 3-HK metabolism, formation of 3-hydroxyanthranilic acid (3-HAA), is catalyzed by pyridoxal-5-phosphate (P5P)-dependent kynureninase (KYNase). P5P defi ciency, associated with infl ammation, stress, and treatment with antipsychotic drugs, diverts metabolism of overproduced 3-HK from formation of 3-HAA to the excessive formation of 3-hydroxykynurenic acid (3H-KYNA). Human and experimental studies suggested diabetogenic (e.g., impairment of production, release, and biological activity of insulin) effect of KYN, 3H-KYNA, KYNA, and their metabolites. We propose that one of the mechanisms of increased association of IR (and T2D) with aging, obesity, depression, neurodegenerative diseases, schizophrenia, and treatment with antipsychotic drugs is overproduction of 3H-KYNA resulting from upregulated formation of 3-HK augmented by P5P defi ciency. Pharmacological regulation of upand downstream TRP-KYN metabolic pathways might be a new approach for prevention and treatment of IR (and IR progression to T2D) associated with aging, obesity, depression, neurodegenerative diseases, schizophrenia, and treatment with antipsychotic drugs.

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Section: Dysregulation Of Trp-kyn Metabolism In Depressionmentioning

confidence: 73%

3-Hydroxykynurenic Acid and Type 2 Diabetes: Implications for Aging, Obesity, Depression, Parkinson’s Disease, and Schizophrenia

Oxenkrug

2015

Tryptophan Metabolism: Implications for Biological Processes, Health and Disease

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“…15 A substantial, positive and significant association exists between the incidence of diabetes and untreated depression among adults 55 years of age or older. 16 For the people diagnosed with diabetes, the addition of depression serves to increase symptom burden, diabetes-related complications, unemployment, work-related disability and healthcare costs. 17 Individuals with both diabetes and depression have a 2.3 times greater risk of early mortality than do non-depressed people with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Psychological Impacts Among Patients With Type 2 Diabetes Mellitus: A Cross Sectional Study

Subramanian¹,

Rajarajacholan²,

Senguttuvan³

et al. 2016

jemds

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BACKGROUNDPeople with diabetes experience higher rates of psychological disorders like depression, anxiety, eating disorders, phobias, adjustment disorders, substance use, psychotic and bipolar disorders and sexual dysfunction. The most common diagnoses among them being depression and anxiety. The aim of the study is to compare the level of anxiety and depression among diabetic and nondiabetic healthy population and to assess the level of distress and functional level in terms of self-care among the diabetic population.

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“…Psychiatric disorders are known to deteriorate the control of chronic diseases such as DM and metabolic syndrome [5][6][7][8][9]. Particularly concerning DM, associations of eating disorders and depression are frequently reported [8,9].…”

Section: Introductionmentioning

confidence: 99%

Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus

et al. 2011

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Objective To evaluate whether an interdisciplinary intervention program on lifestyle results in better quality of life (QoL) and lower frequencies of depression and binge eating disorder (BED) in individuals at risk for type 2 diabetes mellitus. Methods A total of 177 individuals (32.2% men, age 55.4 ± 12.5 years) at risk for diabetes were allocated to a 9-month traditional (TI) or intensive interdisciplinary intervention (II) on dietary habits and physical activity including psychoeducative groups. They were submitted to questionnaires and clinical and laboratory examinations. Predictors of non-adherence were analyzed by logistic regression. Results Only individuals submitted to II had blood pressure and plasma glucose levels reduced. Frequencies of depression reduced in both interventions but of BED only in II (28.0-4.0%, P \ 0.001). Increments in the scores of SF-36 domains (physical functioning: 11.1 ± 14.0 vs. 5.3 ± 13.0, role-emotional: 20.4 ± 40.2 vs. 6.2 ± 43.8, P = 0.05) were greater in the II than in TI, respectively. Changes in SF-36 correlated with decreases in anthropometry, blood pressure and glucose levels, depression and BED scores. Male gender was independently associated with non-adherence to the II. Conclusions In addition to metabolic benefits, an interdisciplinary approach may induce desirable extrametabolic effects, favoring the control of psychiatric disorders and improving the QoL of individuals at risk for diabetes.

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Depressive Disorder and Incident Diabetes Mellitus: The Effect of Characteristics of Depression

Cited by 165 publications

References 34 publications

3-Hydroxykynurenic Acid and Type 2 Diabetes: Implications for Aging, Obesity, Depression, Parkinson’s Disease, and Schizophrenia

3-Hydroxykynurenic Acid and Type 2 Diabetes: Implications for Aging, Obesity, Depression, Parkinson’s Disease, and Schizophrenia

Psychological Impacts Among Patients With Type 2 Diabetes Mellitus: A Cross Sectional Study

Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus

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