Depressive cardiac reflex elicited by angiographic contrast medium and its inhibition by lidocaine

Vogt, A.; Ri, H. Dal; Schmidt, Gerhard; Kreuzer, H

doi:10.1093/oxfordjournals.eurheartj.a061128

Cited by 2 publications

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“…In our animal investigation the local anesthetics are injected together with the contrast medium solution and increased the acute contrast medium toxicity. At the LD so level the dose of local anesthetic was about 10 times (Tables 1,2) that of the previous animal investigations (13,28).…”

Section: Discussionmentioning

confidence: 78%

“…In cats, YOGT et colI. (28), after an initial intravenous bolus injection (2 mg/kg), infused lidocaine (1 mg/kg/min) and found it to inhibit the bradycardia and blood pressure drop otherwise induced by intraaortic injection of hypertonic contrast media. These two animal investigations show that pretreatment with local anesthetics prior to the subsequent injection of contrast medium may reduce the acute toxicity of the contrast agent.…”

Section: Discussionmentioning

confidence: 99%

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Addition of Local Anesthetics to Contrast Media

Nilsson¹,

Almén²,

Golman³

et al. 1988

Acta Radiol

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The acute intravenous toxicity (i.v. LD 50 ) of solutions of the ratio 1.5 contrast media metrizoate or diatrizoate and the ratio 3.0 contrast medium metrizamide was determined in mice with and without the addition oflocal anesthetics to the solutions. The two local anesthetics mepivacaine or lidocaine were added to final concentrations up to 2.0 mg/ml of the contrast medium solutions. This corresponds to clinically used concentrations. All additions of local anesthetics to the solutions increased the mortalities caused by the contrast medium solutions. Addition of local anesthetics to a final concentration of 2 mg/ml approximately doubled the acute intravenous toxicity of the contrast media. The ratio 3 contrast media produce less hypertonic solutions than the ratio 1.5 contrast media and should be preferred for angiography because they cause less pain and do not require the addition of local anesthetics which increase the acute toxicity of the solutions.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%