Depressive and Obsessive-Compulsive Symptoms in Hyperserotonemic Parents of Children with Autistic Disorder

Cook, Edwin H.; Charak, David; Arida, Janet; Spohn, Jamie L.; Roizen, Nancy; Leventhal, Bennett L.

doi:10.1097/00004583-199407000-00036

Cited by 11 publications

(13 citation statements)

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“…Studies have also found an excess of depression in first degree relatives of autistic persons compared with controls with Down syndrome; this excess of depression in families does not seem to be related to the stress of raising a child with autism (Piven and Palmer, 1999). Furthermore, it has been shown that parents of autistic children who show altered serotonin levels themselves score high on depression and anxiety symptoms (Cook et al, 1994), which suggests an interplay of common neurochemical factors between depression and autism, at least in some cases.…”

Section: Genetic Factorsmentioning

confidence: 99%

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Ghaziuddin

Greden

2002

Journal of Autism and Developmental Disorders

464

119

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Although several studies have investigated the occurrence of medical and neurological conditions in persons with autism, relatively few reports have focused on the phenomenology and treatment of psychiatric disorders in this population. There is emerging evidence that depression is probably the most common psychiatric disorder that occurs in autistic persons. In this review, we examine the factors that influence the presence of depression in this population, such as the level of intelligence, age, gender, associated medical conditions, and the role of genetic factors and life events. We discuss the various forms of treatment available and highlight the need for early detection.

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Section: Genetic Factorsmentioning

confidence: 99%

Untitled

Ghaziuddin

Greden

2002

Journal of Autism and Developmental Disorders

464

119

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“…It remains unclear as to whether psychiatric disorders in general, and specific disorders such as depression and anxiety, comprise part of the broad phenotype specific to autism (Bailey, Palferman, Heavey, & Le Couteur, 1998; Cook et al., 1994; Piven, 1997; Piven et al., 1991; Smalley, MacCracken, & Tanguay, 1995). Because no specific genes have yet been found for autism or for the broad phenotype of autism, it is important to operationalize the behavioral phenotype to enable the association of genes and behavior at a later time.…”

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confidence: 99%

Psychiatric disorders in parents of children with autism: a meta‐analysis

Yirmiya

Shaked

2004

Child Psychology Psychiatry

160

104

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“…Studies of blood levels in probands find an elevation in approximately 20%–30% of cases [Anderson et al, 1987; Cook and Leventhal, 1996; Anderson, 2002]. Elevation of serotonin is present in family members of autistic subjects with hyperserotonemia [Kuperman et al, 1985; Abramson et al, 1989; Cook et al, 1990, 1994; Leventhal et al, 1990; Piven et al, 1991]. Pharmacologic studies implicate the serotonin system in autism [Cook et al, 1994; McDougle et al, 1996; Potenza and McDougle, 1997].…”

Section: Methodsmentioning

confidence: 99%

“…Elevation of serotonin is present in family members of autistic subjects with hyperserotonemia [Kuperman et al, 1985; Abramson et al, 1989; Cook et al, 1990, 1994; Leventhal et al, 1990; Piven et al, 1991]. Pharmacologic studies implicate the serotonin system in autism [Cook et al, 1994; McDougle et al, 1996; Potenza and McDougle, 1997]. In addition to recent genome‐wide linkage findings on 17q, there is specific evidence for the involvement of the serotonin transporter protein gene on 17q (HTT) [Cook et al, 1997; Klauck et al, 1997; Marazziti et al, 2000; Yirmiya et al, 2001, Tordjman et al, 2001; Kim et al, 2002].…”

Section: Methodsmentioning

confidence: 99%

Current perspectives on the genetic analysis of autism

Coon

2006

American J of Med Genetics Pt C

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Although no definitive genetic mutations leading to autism susceptibility have been established, the field has many new resources to tackle this difficult problem. Numbers of families at many research sites are now large, and new collaborations among these groups will allow for collections of subjects with enough statistical power to detect relatively small gene effects. New technological advances in genotyping will allow for more fine‐grained genetic analysis, and more sophisticated techniques have been developed to address the vast amounts of data acquired. Researchers have also begun to focus on intermediate phenotypes associated with autism, such as elevated serotonin, increased head circumference, social difficulties, or language impairment or delay. These phenotypes may help to stratify affected cases into more genetically homogeneous subgroups, and may also occur in their clinically unaffected relatives. The study of intermediate phenotypes may allow investigators to find common gene variants that lead to autism susceptibility. Here we discuss the major intermediate phenotypes, and give an overview of current genetic analysis techniques. © 2006 Wiley‐Liss, Inc.

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Depressive and Obsessive-Compulsive Symptoms in Hyperserotonemic Parents of Children with Autistic Disorder

Cited by 11 publications

References 0 publications

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Psychiatric disorders in parents of children with autism: a meta‐analysis

Current perspectives on the genetic analysis of autism

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