Depressive and anxiety symptomatology among people with asthma or atopic dermatitis: A population-based investigation using the UK Biobank data

Hussain, Sahir; Ronaldson, Amy; Torre, Jorge Arias de la; Sima, Rodica; Hatch, Stephani L.; Hotopf, Matthew; Dregan, Alexandru

doi:10.1016/j.bbi.2020.08.003

Cited by 12 publications

(8 citation statements)

References 38 publications

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Section: Discussionmentioning

confidence: 99%

“…Conforming to the literature, more than 30% of patients with AD have significant psychiatric and psychosocial comorbidities [27]. An increased risk of depression and anxiety [11,[28][29][30], risk of suicide [31], and sleep disorders [32,33] have been studied and tested using validated questionnaires. However, sexual problem assessment and sexual dysfunction (SD) are usually only insufficiently recorded.…”

Section: Discussionmentioning

confidence: 99%

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Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

Linares‐González

Lozano-Lozano

Gutiérrez‐Rojas

et al. 2021

Life

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Atopic dermatitis (AD) is a chronic inflammatory disease of the skin whose main symptom is pruritus and may affect all age ranges. Regarding the prevalence, it has been estimated at around 10% of the world population. Many concomitant diseases have been associated with AD, but the causal relationship between AD and psychological impairment has not been clearly established. Scientific literature studying the probable association between male or female sexual dysfunction and dermatological pathology is limited, even more so in AD. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines and the Cochrane Collaboration methodology for systematic reviews. All relevant articles in English were identified through a search from inception to 10 December 2020, including the following databases: Medline (via PubMed), Scopus, Web of Science Core Collection, and SciELO. The results of the search were compiled using the COVIDENCE software for systematic reviews. The methodological quality of the included studies was done using the “Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies” and the “Quality Assessment of Case-Control Studies” developed by the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH). Our search yielded potentially relevant studies. Five studies that evaluated the prevalence of sexual dysfunction in atopic dermatitis were retrieved after applying the selection criteria. The present systematic review achieved data from 8088 patients with atopic dermatitis from four articles. Sample sizes for atopic dermatitis patients ranged from 266 to 3997. We identified one cohort study with four years of follow-up, three studies with a cross-sectional design, and one case-control study. Three studies reported data disaggregated by the severity of atopic dermatitis. Two studies included healthy controls with a total sample size of 1,747,755 subjects. Two studies compared data with other dermatological conditions such as psoriasis. In conclusion, we can establish that unlike other psychological comorbidities such as anxiety and depression, sexual dysfunction is a field scarcely explored in the literature. This sexual dysfunction focuses on the male sex in large population studies and in clinical diagnoses without exploring it through specific and validated questionnaires in this regard. Further studies focused on both genders are needed. It is important to correlate this sexual dysfunction with the severity of the disease, previous treatments, and cardiovascular comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

Linares‐González

Lozano-Lozano

Gutiérrez‐Rojas

et al. 2021

Life

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“…9,10 The shared pathogenesis of dysregulated inflammatory response has been reported to trigger the onset of depression and anxiety in the general population. [11][12][13][14] The findings on the association between asthma and postpartum depression have, however, been inconsistent. [15][16][17] The prevalence of atopic diseases, mostly developed before childbearing ages, is on the increase.…”

Section: Introductionmentioning

confidence: 99%

“…Atopic dermatitis, asthma, and allergic rhinitis are the most common atopic diseases that affect approximately 20% of the population worldwide, and often develop sequentially, known as the “atopic march” 9,10 . The shared pathogenesis of dysregulated inflammatory response has been reported to trigger the onset of depression and anxiety in the general population 11–14 . The findings on the association between asthma and postpartum depression have, however, been inconsistent 15–17 .…”

Section: Introductionmentioning

confidence: 99%

The association of asthma, atopic dermatitis, and allergic rhinitis with peripartum mental disorders

Ren

Chen

et al. 2021

Clinical & Translational All

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Background: Atopic diseases are characterized by dysregulated inflammatory response, which may incur the onset of peripartum mental disorders, but the impact remains unknown. This study examined whether and to what extent the history of atopic diseases is associated with newly onset peripartum mental disorders.Methods: Using population-based registries, we identified all primiparous women who gave birth to live singletons in Denmark during 1978Denmark during -2016.The exposure was hospital contact due to the three major types of atopic diseases-asthma, atopic dermatitis, and allergic rhinitis-before conception. The primary outcome was any hospital contact for mental disorder during pregnancy and 1-year postpartum, which was further classified into affective disorders, neurotic, stress-related and somatoform disorders, and substance abuse. The follow-up started from the date of conception and ended at the date of the first diagnosis of mental disorders, 1-year postpartum, death, emigration, or December 31, 2016, whichever came first. Cox regression was used, adjusted for calendar year, age at childbirth, education, residence, and Charlson comorbidity index.Results: A total of 24,016 (2.6%) women received diagnosis of at least one of the three atopic diseases before conception (asthma, 1.7%; atopic dermatitis, 0.6%; and allergic rhinitis, 0.8%). Exposure to asthma, atopic dermatitis, or allergic rhinitis was associated with a 37% increased overall risk of peripartum mental disorders (hazard ratio [HR], 1.37; 95% confidence interval [CI], 1.27-1.49). Higher risks were observed among women with more frequent hospital contacts for atopic disease (HR, 1.80; 95% CI, 1.37-2.35; ≥5 times), and with recent hospital contacts for atopic disease (HR, 1.74; 95% CI, 1.48-2.06; within 2 years before conception). Specific associations were observed between asthma and neurotic, stress-related and somatoform disorders (HR, 1.40; 95% CI, 1.21-Tai Ren and Jiawen Chen contributed equally to this work as co-first authors.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Известно, что атопический дерматит (АтД), протекающий с такими симптомами, как кожный зуд, высыпания на коже, косметические дефекты (при появлении дерматита на открытых участках тела), оказывает психотравмирующее влияние на пациентов и снижает качество их жизни. АтД ассоциируется с повышенным уровнем стигматизации, социальной дезадаптации, тревоги и депрессии не только среди пациентов, но и членов их семей [7,14].…”

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Possibilities of cognitive-affective disorders correction in patients with atopic dermatitis using selanc regulatory peptide

Круглова¹,

Novikova²,

Донцова³

et al. 2020

Kursk Scientific and Practical Bulletin “Man and His Health”

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Objective: To evaluate the efficacy of the selank regulatory peptide against cognitive-affective disorders in patients with atopic dermatitis (AD). Material and methods. The analysis of cognitive-affective disorders of 65 patients with atopic dermatitis (AD), randomized into 2 statistically comparable groups, was carried out. Patients of the first group received basic drug therapy (BT) for AD, the second group - a combination of selank and BT (S + BT) intranasally, 2 drops in each nasal passage, 3 times a day, for 14 days. The control group consisted of 30 healthy individuals. The levels of personal (LT) and reactive (RT) anxiety, alexithymia, the level of β-endorphin in the blood, and the quality of life (QOL) before treatment and after 30 days from its start were assessed. Results. In patients with AD, the level of RT was 4.2 times higher than in the control group, RT - 3.2 times, alexithymia - 18 times. In the BT group, 30 days after the start of treatment, RT decreased 1.4 times and RT - 1.3 times. In the C+BT group, the decrease in LT and RT was equally significant - by 2.4 times. The levels of alexithymia and blood β-endorphin in the BT group did not change significantly. In the S+BT group, alexithymicity of patients decreased by 1.2 times, and the level of β-endorphin in the blood increased by 1.9 times. The quality of life index in the BT group decreased 1.2 times after 30 days from the start of therapy, and 1.7 times in the S + BT group. Conclusion. Patients with AD are characterized by the increased levels of personal and reactive anxiety and alexithymia, which reduce their quality of life. The use of the selank regulatory peptide in the complex treatment of patients with AD has a corrective effect on affective-cognitive impairment, contributing to a decrease in the levels of personal and reactive anxiety, alexithymia, increases the level of β-endorphin in the blood and improves the quality of life of patients.

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Depressive and anxiety symptomatology among people with asthma or atopic dermatitis: A population-based investigation using the UK Biobank data

Cited by 12 publications

References 38 publications

Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

The association of asthma, atopic dermatitis, and allergic rhinitis with peripartum mental disorders

Possibilities of cognitive-affective disorders correction in patients with atopic dermatitis using selanc regulatory peptide

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