Depressionen nach zerebrovaskulären Ereignissen

Abstract

In spite of the high incidence and prevalence of psychiatric complications after cerebrovascular injury few results have remained uncontradicted so far. This article focuses on the variety of psychiatric disorders after stroke reviewing recent literature and concentrating in particular on Post-stroke Depression. The prevalence of depressive disorders following stroke is assessed between 20 and 50%. Serious consequences for post-stroke depressed subjects are their increased mortality, poor rehabilitation outcome and long-term affected quality of life. Nevertheless, depressive disorders following stroke usually remain untreated. To this date the effectiveness of only a few drugs has been studied in controlled clinical trials (Nortriptylin, Citalopram, Imipramin, Mianserin). Besides describing clinical presentation, epidemiology, pathogenesis and consequences of post-stroke depressive disorders for the patient different authors' statements are listed and critically commented. Finally recommendations concerning therapeutic intervention are mentioned.

"Poststroke Depression"

“…In der Literatur finden sich einige gut strukturierte tabellarische Darstellungen, die die Vielzahl der Studien zur Prävalenz unter differenziellen Gesichtspunkten ordnen bzw. zusammenfassen [15,25,59]. Nachfolgende Zusammenstellung erfolgte in erster Linie unter dem Gesichtspunkt der Klassifizierung einer PSD.Ausgehend von dem zur Diagnose herangezogenen Kriterium enthält sie Angaben über die jeweils eingesetzten Assessment-Verfahren, den Erhebungszeitpunkt und die Prävalenzrate.…”

Efficacy and Safety of Citalopram in Treating Post-Stroke Depression: A Meta-Analysis

“…PSD not only affects the course of rehabilitation; it is also a heavy burden on the families supporting the patients. PSD even increases mortality due to stroke [1][2][3][4][5] .…”