Dépression respiratoire sévère tardive après administration intrathécale de morphine et de clonidine chez un patient de 70 ans

Opioid-induced respiratory depression (OIRD) is a potentially fatal complication of treatment with opioids. Little is known about patient- and case-related factors associated with OIRD. One-hundred-and-five available case reports on OIRD in 134 patients (12 years and older) in the perioperative, obstetric or emergency care setting, published since 1980, were retrieved from the literature. The most frequently reported case-related factors were: morphine use, perioperative setting and obstetrics, neuraxial or intravenous administration. The most frequently reported patient-related factors involved were: female gender, sleep-disordered breathing, obesity, renal impairment, pulmonary disease and CYP450 enzyme polymorphisms. While the analysis has limitations, it confirms that OIRD in the acute setting involves complex and interrelated factors and is a significant cause of preventable morbidity and mortality.

show abstract

Hipoacusia en un paciente tras administración de morfina intratecal

Pingarrón

Bartol

Vaquero

et al. 2014

Rev. Soc. Esp. Dolor

View full text Add to dashboard Cite

Muriel C. Hipoacusia en un paciente tras administración de morfina intratecal. Rev Soc Esp Dolor 2014; 21(2): 89-91. ABSTRACTThe administration of intrathecal opioids is a common technique when treating patients with chronic pain. The chosen drug is morphine due to its pharmacokinetic characteristics that determine a good analgesic quality, still required monitoring of patients for the first 24 hours because of their fundamental risk of respiratory depression.We present a case of hearing loss associated with opioid intoxication after administration of morphine by intrathecal infusion pump in a patient with chronic pain with post-laminectomy syndrome. The patient was treated with respiratory support and continuous intravenous infusion of naloxone. The hearing loss reverted within one hour after gradual increase of the treatment. The different articles that we analyzed include nausea, vomiting, pruritus, urinary retention and respiratory depression as side effects of intrathecal morphine. There is no reference to the onset of hearing loss associated with intrathecal opioid intoxicaton in the literature we have reviewed so far.

show abstract

Dépression respiratoire sévère tardive après administration intrathécale de morphine et de clonidine chez un patient de 70 ans

Cited by 4 publications

References 12 publications

Antibiotic Prophylaxis for Surgery: Time to Get Our House in Order

Antibiotic Prophylaxis for Surgery: Time to Get Our House in Order

Opioid-Induced Respiratory Depression in the Acute Care Setting: A Compendium of Case Reports

Hipoacusia en un paciente tras administración de morfina intratecal

Contact Info

Product

Resources

About