Depression-related anhedonic behaviors caused by immobilization stress: a comparison with nicotine-induced depression-like behavioral alterations and effects of nicotine and/or "antidepressant" drugs

Hayase, Tamaki

doi:10.2131/jts.36.31

Cited by 29 publications

(25 citation statements)

References 45 publications

(81 reference statements)

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“…Depression like behavioral alteration can be produced by the stressors such as immobilization stress (Hyase, 2011). The results of the present study showed that the immobilization stress enhanced the immobility period of the mice in both TST and FST significantly as compared to the vehicle treated unstressed mice.…”

Section: Discussionsupporting

confidence: 46%

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GABAergic Influence in the Antidepressant Effect of Fluoxetine in Unstressed and Stressed Mice

2017

J App Pharma Sci

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Objective:To determine the influence of GABA in the antidepressant effect of fluoxetine in unstressed and stressed mice. Materials and methods: Male swiss albino mice were used in the present study. Mice were stressed by immobilization for 2h. Mice subjected to immobilization were considered as stressed mice and mice not subjected to immobilization were considered as unstressed mice. Depression like behavioral alterations in unstressed and stressed mice was measured by tail suspension test (TST) followed by forced swim test (FST). Results:The present study showed that the immobilization stress of 2h significantly enhanced the immobility period of mice in both TST and FST. Fluoxetine (FLX) (20 mg/kg, i.p.) significantly reduced the immobility period of both unstressed and stressed mice significantly as compared to their respective controls. Diazepam (DZP) (2 and 4 mg/kg, i.p.) significantly increased the immobility period of the unstressed mice whereas significantly reduced the immobility period of stressed mice in both TST and FST as compared to their respective controls. The combine treatment of DZP (2 mg/kg, i.p.) and FLX (20 mg/kg, i.p.) to the unstressed mice reduced the immobility period of unstressed mice in both TST and FST significantly as compared to the vehicle and DZP (2 mg/kg, i.p.) treated unstressed mice in TST. The co-administration of DZP (2 mg/kg, i.p.) and FLX (20 mg/kg, i.p.) before the immobilization of 2h significantly reduced the immobility period of stressed mice significantly as compared to the vehicle treated stressed mice in both TST and FST; whereas significantly as compared to the FLX (20 mg/kg, i.p.) treated stressed mice in TST only. Conclusion: It has been concluded that the GABAergic influence is involved in the compromised antidepressant effect of the fluoxetine in stressed mice.

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Section: Discussionsupporting

confidence: 46%

“…Stress induces depression like behavioral alteration in the laboratory animals subjected to the stress (Hyase, 2011). Depression like behavioral alteration in the laboratory animals can be measure by using TST and FST (Porsolt et al, 1977;Steru et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

GABAergic Influence in the Antidepressant Effect of Fluoxetine in Unstressed and Stressed Mice

2017

J App Pharma Sci

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“…In addition, many concerns exist about the risks of using a potentially hazardous chemical to treat AD patients (Baldinger and Schroeder, 1995). Similarly, literature surveying the effect of nicotine on depressive-like behavior is ambivalent with some preclinical studies reporting decreased (Djuric et al, 1999; Semba and Wakuta, 2008) or increased (Hayase, 2007, 2008, 2011, 2013) depressive behavior with nicotine use.…”

Section: Discussionmentioning

confidence: 99%

Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice

Patel

Grizzell

Holmes

et al. 2014

Front. Aging Neurosci.

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Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in transgenic 6799 mice (Tg6799 mice) when treated prior to the development of the pathology. We have also shown that cotinine reduces depressive-like behavior in normal and chronically stressed C57BL/6 mice. Here, we extend our previous studies by investigating the effects of cotinine on the progression of AD-like pathology, depressive-like behavior, and the mechanisms underlying its beneficial effects in Tg6799 mice when left untreated until after a more advanced stage of the disease's development. The results show that vehicle-treated Tg6799 mice displayed an accentuated loss of working memory and an abundant Aβ plaque pathology that were accompanied by higher levels of depressive-like behavior as compared to control littermates. By contrast, prolonged daily cotinine treatment to Tg6799 mice, withheld until after a mid-level progression of AD-like pathology, reduced Aβ levels/plaques and depressive-like behavior. Moreover, this treatment paradigm dramatically improved working memory as compared to control littermates. The beneficial effects of cotinine were accompanied by an increase in the expression of the active form of protein kinase B and the postsynaptic density protein 95 in the hippocampi and frontal cortices of Tg6799 mice. This suggests that cotinine halts the progression of AD-like pathology while reducing depressive-like behavior by stimulating signaling pathways supporting synaptic plasticity in Tg6799 mice. The potential use of cotinine to treat cognitive and non-cognitive symptoms of AD is discussed.

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“…All parameters were analyzed automatically by the ActiMot software (TSE, Bad Homburg, Germany) as described before (Brzozka et al 2011). Anhedonia was evaluated by tail suspension test as described (Hayase T, 2011). Briefly, a cube of 35 cm each side with an open front was used to perform the experiment.…”

Section: Methodsmentioning

confidence: 99%

Chronic exposure to cannabinoids during adolescence causes long‐lasting behavioral deficits in adult mice

et al. 2016

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Regular use of marijuana during adolescence enhances the risk of long‐lasting neurobiological changes in adulthood. The present study was aimed at assessing the effect of long‐term administration of the synthetic cannabinoid WIN55212.2 during adolescence in young adult mice. Adolescent mice aged 5 weeks were subjected daily to the pharmacological action of WIN55212.2 for 3 weeks and were then left undisturbed in their home cage for a 5‐week period and finally evaluated by behavioral testing. Mice that received the drug during adolescence showed memory impairment in the Morris water maze, as well as a dose‐dependent memory impairment in fear conditioning. In addition, the administration of 3 mg/kg WIN55212.2 in adolescence increased adult hippocampal AEA levels and promoted DNA hypermethylation at the intragenic region of the intracellular signaling modulator Rgs7, which was accompanied by a lower rate of mRNA transcription of this gene, suggesting a potential causal relation. Although the concrete mechanisms underlying the behavioral observations remain to be elucidated, we demonstrate that long‐term administration of 3 mg/kg of WIN during adolescence leads to increased endocannabinoid levels and altered Rgs7 expression in adulthood and establish a potential link to epigenetic changes.

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Depression-related anhedonic behaviors caused by immobilization stress: a comparison with nicotine-induced depression-like behavioral alterations and effects of nicotine and/or "antidepressant" drugs

Cited by 29 publications

References 45 publications

GABAergic Influence in the Antidepressant Effect of Fluoxetine in Unstressed and Stressed Mice

GABAergic Influence in the Antidepressant Effect of Fluoxetine in Unstressed and Stressed Mice

Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice

Chronic exposure to cannabinoids during adolescence causes long‐lasting behavioral deficits in adult mice

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