Depression predicts mortality and hospitalization in heart failure: A six-years follow-up study

Ramos, Sónia; Prata, Joana; Bettencourt, Paulo; Gonçalves, Francisco Rocha; Coelho, Rui

doi:10.1016/j.jad.2016.05.024

Cited by 29 publications

(30 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Depression in HF has become a major focus of research in recent years as the burden of HF continues to increase and many studies suggest poorer outcomes in HF patients reporting depression . Co‐morbid depression in HF is associated with poor quality of life, lower treatment adherence, greater morbidity and mortality, increased hospitalization and higher health care costs . Major depression is detected in 20–40% of patients with chronic HF and this is about four to five times higher than in the general population .…”

Section: B Higher Cortical Functionmentioning

confidence: 99%

“…59 Co-morbid depression in HF is associated with poor quality of life, lower treatment adherence, greater morbidity and mortality, increased hospitalization and higher health care costs. 60,61 Major depression is detected in 20-40% of patients with chronic HF and this is about four to five times higher than in the general population. 62 The prevalence of depression is higher in women than in men [32.7% (range 11-67%) vs. 26.1% (7-63%)].…”

Section: Depression and Anxiety In Patients With Heart Failurementioning

confidence: 99%

See 1 more Smart Citation

Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association

Doehner

Ural

Hæusler

et al. 2017

European J of Heart Fail

135

125

View full text Add to dashboard Cite

Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys-)functions. Bi-directional feedback interactions between the heart and the brain are inherent in the pathophysiology of HF: (i) the impaired cardiac function affects cerebral structure and functional capacity, and (ii) neuronal signals impact on the cardiovascular continuum. These interactions contribute to the symptomatic presentation of HF patients and affect many co-morbidities of HF. Moreover, neuro-cardiac feedback signals significantly promote aggravation and further progression of HF and are causal in the poor prognosis of HF. The diversity and complexity of heart and brain interactions make it difficult to develop a comprehensive overview. In this paper a systematic approach is proposed to develop a comprehensive atlas of related conditions, signals and disease mechanisms of the interactions between the heart and the brain in HF. The proposed taxonomy is based on pathophysiological principles. Impaired perfusion of the brain may represent one major category, with acute (cardio-embolic) or chronic (haemodynamic failure) low perfusion being sub-categories with mostly different consequences (i.e. ischaemic stroke or cognitive impairment, respectively). Further categories include impairment of higher cortical function (mood, cognition), of brain stem function (sympathetic over-activation, neuro-cardiac reflexes). Treatment-related interactions could be categorized as medical, interventional and device-related interactions. Also interactions due to specific diseases are categorized. A methodical approach to categorize the interdependency of heart and brain may help to integrate individual research areas into an overall picture.

show abstract

Section: B Higher Cortical Functionmentioning

confidence: 99%

Section: Depression and Anxiety In Patients With Heart Failurementioning

confidence: 99%

Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association

Doehner

Ural

Hæusler

et al. 2017

European J of Heart Fail

135

125

View full text Add to dashboard Cite

show abstract

“…2 Conversely, patients with symptoms of depression are at increased risk of HF. 5,6 Pathogenetically oriented treatment options remain scarce. Even though myocardial infarction (MI) and ischaemic heart disease present the leading cause of HF in Europe 1 and an important risk factor for the subsequent development of depression, 4 the pathogenesis of increased vulnerability to depression and anxiety in response to MI remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…4 Patients with HF and co-morbid depression show poorer clinical outcome, including elevated morbidity, rate of hospitalization, and mortality. 5,6 Pathogenetically oriented treatment options remain scarce. Psychotherapy and antidepressant medication have not shown beneficial impact on patient outcome so far.…”

Section: Introductionmentioning

confidence: 99%

Learned helplessness reveals a population at risk for depressive‐like behaviour after myocardial infarction in mice

et al. 2019

View full text Add to dashboard Cite

Aims Myocardial infarction (MI) and heart failure (HF) are risk factors for the development of depression, additionally worsening the quality of life and patient outcome. How HF causes depression and how depression promotes HF remain mechanistically unclear, which is at least partly caused by the difficulty of in vivo modelling of psychosomatic co‐morbidity. We aimed to study the potential sequence of events with respect to different depression aspects upon HF. Methods and results Male C57BL6 mice underwent MI, followed by behavioural and echocardiographic characterization. Motility, exploration, and anxiety‐like behaviour were unaffected in mice after MI. We did not observe increased depressive‐like behaviour in the sucrose preference, tail suspension, or Porsolt forced swim test. Mice did not display signs of learned helplessness (LH) when compared to sham. Accordingly, cluster analysis revealed only a slightly higher quota of LH in HF (38%) vs. sham mice (32%). But strikingly, three‐group cluster analysis revealed an additional intermediate subpopulation at risk for LH after HF (29%). Interestingly, this population featured elevated cardiac expression of nr4a1. Conclusions The LH paradigm uncovered a subtle predisposition to depressive‐like behaviour after MI, whereas testing for anhedonia and despair was insufficient to show a behavioural shift in mice. Therefore, we suggest an accumulating risk profile and a multiple‐hits hypothesis regarding the pathogenesis of co‐morbid depression after MI. Symptoms of LH may present a marker of subclinical depression after MI, the impact of which remains to be investigated. The proposed sequence of behavioural testing enables the mechanistic dissection of cardio‐psychogenic signalling in the future.

show abstract

“…Frequent hospitalizations, fluid restrictions, long-term use of medications, and the number of health visits required can negatively impact on quality of life, relationships, and the ability to function in normal life activities and work capacity, leading to depression (Sobral Lacerda, Alves Cirelli, Leite de Barros, & de Lima Lopes, 2017). Depression might also lead to poor self-care maintenance and non-compliance with prescribed pharmacological and non-pharmacological therapies, including medications and fluid restrictions(Chang, Wu, Chiang, & Tsai, 2017;Gaye et al, 2017;Ramos, Prata, Bettencourt, Goncalves, & Coelho, 2016).…”

mentioning

confidence: 99%

Effectiveness of cognitive behavior therapy for patients with heart failure and depression: A systematic review protocol

Shabu

Jayasekara

2019

Nursing & Health Sciences

View full text Add to dashboard Cite

The objective of this review is to determine the effectiveness of cognitive behavior therapy for patients with heart failure and depression, aged ≥18 years, in institutionalized healthcare settings. More specifically, the review aims to identify which cognitive behavior therapy strategy/strategies, including the method of delivery, is the most effective for the management of depression in hospitalized patients with heart failure. The review question is as follows: Is cognitive behavior therapy effective in reducing symptoms of depression in patients with heart failure? This systematic review will be conducted in accordance with the Joanna Briggs Institute methodology for systematic reviews of effectiveness evidence. This review only includes randomized controlled trials assessing the effectiveness of cognitive behavior therapy as a treatment for depression in adults (aged ≥18 years) with heart failure, compared with usual care, which might include medications.

show abstract

Depression predicts mortality and hospitalization in heart failure: A six-years follow-up study

Cited by 29 publications

References 72 publications

Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association

Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association

Learned helplessness reveals a population at risk for depressive‐like behaviour after myocardial infarction in mice

Effectiveness of cognitive behavior therapy for patients with heart failure and depression: A systematic review protocol

Contact Info

Product

Resources

About