Depression Predicts Increased Incidence of Adverse Health Outcomes in Older Mexican Americans With Type 2 Diabetes

Black, Sandra A.; Markides, Kyriakos S.; Ray, L.

doi:10.2337/diacare.26.10.2822

Cited by 494 publications

(454 citation statements)

References 36 publications

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“…This suggests depression and diabetes may have an adverse synergistic effect leading to the higher mortality rate. This effect has also been observed cross-culturally, in an older, Mexican American population (Black et al, 2003).…”

Section: Consequences Of Depression In People With Diabetessupporting

confidence: 65%

Epidemiology of depression in diabetes: International and cross-cultural issues

Lloyd¹,

Roy²,

Nouwen³

et al. 2012

Journal of Affective Disorders

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This paper reviews the most up-to-date epidemiological evidence of the relationship between depression and diabetes, and considers the risk factors for the development of depression and the consequences of depression in diabetes with an emphasis on international and cross-cultural data. The difficulties that researchers face when epidemiological studies require assessment of psychological phenomena, such as depression, across different cultural settings are explored. Methods:Relevant papers were sought on the epidemiology of diabetes and depression in people with diabetes by undertaking a literature search of electronic databases including MEDLINE, Psych-INFO, CINAHL and EMBASE. These papers were assessed by the authors and a narrative review of the relevant literature was composed.Results: Systematic reviews of the prevalence of depression in people with diabetes have focused on studies conducted in English speaking countries and emerging data suggest that there may be international variations in prevalence and also in how symptoms of depression are reported. There appears to be a bi-directional relationship between depression and diabetes, with one influencing the other; however, research in this area is further complicated by the fact that potential risk factors for depression in people with diabetes often interact with each other and with other factors. Further research is needed to elucidate the causal mechanisms underlying these associations. Limitations:Data from non-English speaking countries remain scarce and so it is difficult to come to any firm conclusions as to the international variation in prevalence rates of comorbid diabetes and depression in these countries until further research has been conducted. Conclusion:It is important to take a culture-centered approach to our understanding of mental health and illness and has outlined some of the key issues related to the development of culturally sensitive depression screening tools. In order to come to any firm conclusions about the international variation in prevalence of co-morbid diabetes and depression, issues of culture and diversity must be taken into account prior to conducting international epidemiological studies.

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Section: Consequences Of Depression In People With Diabetessupporting

confidence: 65%

Epidemiology of depression in diabetes: International and cross-cultural issues

Lloyd¹,

Roy²,

Nouwen³

et al. 2012

Journal of Affective Disorders

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“…Following this evidence, it is reasonable to assume that the successful treatment of comorbid depression may facilitate the provision of optimal diabetes care to this highrisk patient group (and support of self-care) [4][5][6][7][8][9][10], and the established risks of…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…18 subsequent long-term morbidity based on comorbid depression in diabetes [4][5][6] might be effectively reduced. A C C E P T E D M A N U S C R I P T …”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Depression is considered to be an adverse condition in people with diabetes because of evidence supporting significantly elevated risks of developing long-term complications of diabetes [4][5][6] as well as significantly increased cardiovascular and all-cause mortality [7,8]. Furthermore, a meta-analysis by Gonzalez et al [9] based on 47 studies and over 17,000 subjects showed depression to be associated with significantly reduced diabetes treatment adherence.…”

Section: Introductionmentioning

confidence: 99%

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Depression is linked to hyperglycaemia via suboptimal diabetes self-management: A cross-sectional mediation analysis

Schmitt

Reimer

Hermanns

et al. 2017

Journal of Psychosomatic Research

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Depression is linked to hyperglycaemia via suboptimal diabetes self-management: A cross-sectional mediation analysis. The address for the corresponding author was captured as affiliation for all authors. Please check if appropriate. Psr(2016Psr( ), doi: 10.1016Psr( / j.jpsychores.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T 1 Abstract ObjectiveTo analyse if the association between depressive symptoms and hyperglycaemia is mediated by diabetes self-management. Methods430 people with diabetes (57.7% type 1, 42.3% type 2) were cross-sectionally assessed using validated self-report scales for depressive symptoms (Center for ResultsThe hypothesised model of depressive symptoms, diabetes self-management and hyperglycaemia fit the data well for both diabetes types (SRMR ≤ 0.04, TLI ≥ 0.99, CFI > 0.99, RMSEA ≤ 0.02 for both models). In both the type 1 and type 2 diabetes group, higher depressive symptoms were associated with lower self-management (P < 0.001), and lower self-management was associated with higher HbA 1c (P < 0.001).Results indicated that the association between depressive symptoms and hyperglycaemia was significantly mediated by suboptimal diabetes self-management in both type 1 and type 2 diabetes patients (P < 0.001). Significant direct associations ACCEPTED MANUSCRIPTA C C E P T E D M A N U S C R I P T 2 between depressive symptoms and hyperglycaemia, not mediated by selfmanagement, could not be observed. ConclusionsThis study provides good evidence supporting that depression is linked to hyperglycaemia via suboptimal diabetes self-management in both major diabetes types.

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“…The literature data have consistently demonstrated a synergistic interaction between diabetes and depression that increases the risk for poor health outcomes [2]. Compared to patients with diabetes alone, patients with depression and diabetes have poorer self-management (i.e.…”

Section: Introductionmentioning

confidence: 99%

Does treatment of subsyndromal depression improve depression and diabetes related outcomes: protocol for a randomised controlled comparison of psycho-education, physical exercise and treatment as usual

Pibernik-Okanović

Ajduković

Lovrenčić

et al. 2011

Trials

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BackgroundThe prevalence of mood difficulties in persons with diabetes is approximately twice that in the general population, affecting the health outcomes and patients' quality of life in an undesirable way. Although subsyndromal depression is an important predictor of a more serious clinical depression, it is often overlooked. This study aims to compare the effects of two non-pharmacological interventions for subsyndromal depression, psychoeducation and physical exercise, with diabetes treatment as usual on mood- and diabetes-related outcomes.Methods and DesignType 2 diabetic patients aged 18-65 yrs. who report mood difficulties and the related need for help in a mail survey will be potential participants. After giving informed consent, they will be randomly assigned to one of the three groups (psychoeducation, physical activity, treatment as usual). Depressive symptoms, diabetes distress, health-related quality of life and diabetes self-care activities will be assessed at baseline, at 6 weeks, 6 months and 12 months. A structured clinical interview for DSM-IV Axis I Disorders (SCID-I) will be performed at baseline and at one-year follow-up in order to determine the clinical significance of the patients' depressive symptoms. Disease-related data will be collected from patients' files and from additional physical examinations and laboratory tests.The two interventions will be comparable in terms of format (small group work), duration (six sessions) and approach (interactive learning; supporting the participants' active roles). The group treated as usual will be informed about their screening results and about the importance of treating depression. They will be provided with brief re-education on diabetes and written self-help instructions to cope with mood difficulties.Primary outcomes will be depressive symptoms. Secondary outcomes will be glycaemic control, diabetes-related distress, self-management of diabetes and health-related quality of life. Tertiary outcomes will be biochemical markers reflecting common pathophysiological processes of insulin resistance, inflammation and oxidative damage that are assumed to be intertwined in both diabetes and depression. The mixed-effect linear model will be used to compare the outcome variables.Power analysis has indicated that the two intervention groups and the control group should comprise 59 patients to enable detection of clinically meaningful differences in depressive symptoms with a power of 80% and alpha = 0.05. Outcomes will be analysed on an intention-to-treat basis.Trial RegistrationISRCTN: ISRCTN05673017

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Depression Predicts Increased Incidence of Adverse Health Outcomes in Older Mexican Americans With Type 2 Diabetes

Cited by 494 publications

References 36 publications

Epidemiology of depression in diabetes: International and cross-cultural issues

Epidemiology of depression in diabetes: International and cross-cultural issues

Depression is linked to hyperglycaemia via suboptimal diabetes self-management: A cross-sectional mediation analysis

Does treatment of subsyndromal depression improve depression and diabetes related outcomes: protocol for a randomised controlled comparison of psycho-education, physical exercise and treatment as usual

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