Depression of platelet counts in apparently healthy children with asymptomatic malaria infection in a Nigerian metropolitan city

Jeremiah, Zaccheaus Awortu; Uko, Emmanuel Kufre

doi:10.1080/09537100701194871

Cited by 25 publications

(23 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in accordance with a previous observation, where it was shown that the pattern of thrombocytopenia and parasitemia did not have a linear relationship among malaria-infected Nigerian children [14]. However, among Papuan adults, platelet counts were negatively correlated with the level P. falciparum parasitemia [12].…”

Section: Discussionsupporting

confidence: 92%

“…Hence, platelet count is being evaluated as a predictor and prognostic feature of malaria infection [11]. However, most research on thrombocytopenia and malaria is focused on non-pregnant populations including adults and children with symptomatic and asymptomatic P. falciparum infections [12-14]. There are few published data on platelets and P. falciparum infection during pregnancy [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thrombocytopenia in pregnant women with Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan

Adam

Rayis

et al. 2012

BMC Clin Pathol

View full text Add to dashboard Cite

BackgroundBlood platelet levels are being evaluated as predictive and prognostic indicators of the severity of malaria infections in humans. However, there are few studies on platelets and Plasmodium falciparum malaria during pregnancy.MethodsA case–control study was conducted at Gadarif Hospital in Eastern Sudan, an area characterized by unstable malaria transmission. The aim of the study was to investigate thrombocytopenia in pregnant women with P. falciparum malaria (cases) and healthy pregnant women (controls).ResultsThe median (interquartile) platelet counts were significantly lower in patients with malaria (N = 60) than in the controls (N = 60), 61, 000 (43,000–85,000) vs. 249,000 (204,000–300,000)/μL, respectively, p < 0.001. However, there was no significant difference in the platelet counts in patients with severe P. falciparum malaria (N = 12) compared with those patients with uncomplicated P. falciparum malaria (N = 48), 68, 000 (33,000-88,000)/μL vs. 61, 000 (45,000–85,000)/μL, respectively, p = 0.8. While none of the control group had thrombocytopenia (platelet count <75, 000/μL), it was found that 6/12 (50%) and 27/48 (56.2%) (p <0.001) of the patients with severe malaria and uncomplicated malaria had thrombocytopenia, respectively. Pregnant women with P. falciparum malaria, compared with the pregnant healthy control group, were at higher risk (OR = 10.1, 95% CI = 4.1–25.18; p < 0.001) of thrombocytopenia. Two patients experienced bleeding, and there was one maternal death due to cerebral malaria where the patient’s platelet count was only 28,000/μL.ConclusionP. falciparum malaria is associated with thrombocytopenia in pregnant women in this setting. More research is needed.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia in pregnant women with Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan

Adam

Rayis

et al. 2012

BMC Clin Pathol

View full text Add to dashboard Cite

show abstract

“…The comparison analysis indicated that the extracts significantly prevented weight loss in dose dependent manner compared to the negative control. The results showed that the physical status of the rats were better and this may be due to ameliorating effect of the plant extracts on acute fluid loss, proteolysis and lipolysis which are usually associated with weight loss in malaria infection (Jeremiah and Uko, 2007). Interaction study (ESJL and ESJR) on NK67 Chloroquine resistance P. berghei infected mice showed additive activities.…”

Section: Effect Of Extracts On Hematological Parameters and Weightmentioning

confidence: 80%

In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre

Olorunnisola¹

2011

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre were tested in vivo for antimalarial activity in Swiss albino mice inoculated with chloroquine resistant Plasmodium berghei NK 67 strain. The two extracts exhibited a significant (p>0.05) dose dependant anti-plasmodial activities in isolation and when combined in the 4-days curative standard test with a high mean of survival time. Although, the standard drug, Arthemether -lumefartrin, showed the highest antimalaria potency (81.4%), those of the leaf (74.4%) and root extracts (54.1%) in isolation and combination (63.4%) compared favorably. The leaf extract demonstrated higher antimalarial potency than the root or combination. The two extracts also produced a significant (p>0.05) positive effect on the weight and hematology values in the treated animals. Phytochemical screening of the plant (leaf and the root extracts) reveals the presences of flavonoids, steroids, terpenoids, tannins and alkaloids. The antiplasmodia activity of these plant extract might be attributed to these phytochemicals compounds. The results showed that the leaf and root of S. jollyanum possesses an anti-malarial activity which was effective against chloroquine resistance strain. This work has validated the traditional uses of S. jollyanum root extract in the treatment of malaria and also reported for the first time the anti-malarial property of the S. jollyanun leaf extract.

show abstract

“…Similarly, a cross-sectional study on Nigerian children with asymptomatic malaria showed that malaria parasites cause a significant reduction in platelet counts with more pronounced reduction in children under 5 years of age [73]. Therefore, thrombocytopenia is not only a feature exhibited by acute malaria, but also a potentially useful indicator for monitoring asymptomatic children in high transmission areas.…”

Section: Role Of the Malaria Parasite In Asymptomatic Malariamentioning

confidence: 99%

The complexities of malaria disease manifestations with a focus on asymptomatic malaria

Laishram

Sutton

Nanda

et al. 2012

Malar J

245

222

View full text Add to dashboard Cite

Malaria is a serious parasitic disease in the developing world, causing high morbidity and mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe and complicated, to mild and uncomplicated, to asymptomatic malaria. Despite a wealth of studies on the clinical severity of disease, asymptomatic malaria infections are still poorly understood. Asymptomatic malaria remains a challenge for malaria control programs as it significantly influences transmission dynamics. A thorough understanding of the interaction between hosts and parasites in the development of different clinical outcomes is required. In this review, the problems and obstacles to the study and control of asymptomatic malaria are discussed. The human and parasite factors associated with differential clinical outcomes are described and the management and treatment strategies for the control of the disease are outlined. Further, the crucial gaps in the knowledge of asymptomatic malaria that should be the focus of future research towards development of more effective malaria control strategies are highlighted.

show abstract

Depression of platelet counts in apparently healthy children with asymptomatic malaria infection in a Nigerian metropolitan city

Cited by 25 publications

References 4 publications

Thrombocytopenia in pregnant women with Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan

Thrombocytopenia in pregnant women with Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan

In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre

The complexities of malaria disease manifestations with a focus on asymptomatic malaria

Contact Info

Product

Resources

About