Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer

Abstract

The prevalence of depression in patients with cancer is high, especially for patients with advanced cancer. In this study, we evaluated the prevalence of depression in prostate cancer patients in Taiwan and the association between depression and mortality in prostate cancer. This study included 1101 newly diagnosed patients with prostate cancer. We tracked the medical information of these patients from diagnosis until the end of 2012. Patients were divided into two groups according to presence or absence of depression diagnosis, and were further divided into three stages by initial treatments: localized or locally advanced, metastatic, and castration-resistant prostate cancer. Of 1101 participants, 267 (24.3%) had depression. By the end of the follow-up period (M = 8.30 ± 3.12 years), 77 (28.8%) patients in the depression group and 194 (23.3%) in the non-depressed group died. Depression was associated with higher mortality risk, (aHR 1.37; 95% CI [ 1.04–1.80]; p value 0.01). Patients in the metastatic prostate cancer group with depression had a significantly higher mortality risk compared to the non-depressed group, (aHR, 1.49; 95% CI [1.05–2.11]; p value 0.02). The impact of depression on mortality risk was not significant in either the localized or locally advanced or the castration-resistant prostate cancer groups. Our study showed that depression is related to an increased mortality risk for patients with prostate cancer, especially for metastatic prostate cancer. These results indicate that urologists should pay attention to the mood and psychiatric disorders of patients with prostate cancer.

Investigation Of The Severity Of Depressive Symptoms In Cancer Patients Receiving Chemotherapy

“…In a retrospective study with 1101 patients investigating the relation between depression, disease stage and mortality in patients with prostate cancer, depression was found to be more common in patients with metastasis than those who are in early/local advanced stage. In addition, it was also demonstrated that the risk of mortality increased markedly in patients with depression (HR: 1.37; %95 CI (1,04-1,80); p:0,01) (25). In the present study, the incidence of depression was found to be significantly higher in patients with metastasis than those without metastasis (p:0.01).…”

Mental distress and need for psychosocial support in prostate cancer patients: An observational cross-sectional study

“…9 In another study, however, patients with a biochemical relapse compared to patients without a biochemical relapse showed almost identical overall satisfaction regarding their physical and mental health. 10 Some studies found an association between advanced prostate cancer and depression, 5,[11][12][13][14] whereas this could not explicitly be shown for anxiety. Johanes et al and Couper et al reported more anxiety symptoms in prostate cancer patients with advanced disease, 11,13 while other studies did not.…”

Mood disorder and cancer onset: evidence from a population-based sample of Australian women

“…In addition, findings may have clinical implications and contribute to understanding the decreased survival observed in cancer patients with depression compared to those patients without. 65,66 Mood disorder is associated with increased morbidity and a reduced life expectancy compared to the general population. As such, the negative association may reflect premature mortality from other medical conditions in the mood disorder group, such as cardiovascular conditions and stroke.…”