Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users

Lee, Young Sik; Han, Doug Hyun; Yang, Kevin C.; Daniels, Melissa; Na, Chul; Kee, Baik Seok; Renshaw, Perry F.

doi:10.1016/j.jad.2007.10.020

Cited by 159 publications

(125 citation statements)

References 27 publications

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“…The same four-week intervention protocol is used for all patients who are referred to our university-based internet addiction clinic and has previously been described in detail. The educational program consists of eight sessions using materials that were designed to promote healthy internet use (Han et al, 2007;KOSIS, 2009;Lee et al, 2008).…”

Section: Education For Online Game Playingmentioning

confidence: 99%

Changes in brain activity in response to problem solving during the abstinence from online game play

Kim¹,

Han²,

Lee³

et al. 2012

Journal of Behavioral Addictions

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Background and aims:Several studies have suggested that addictive disorders including substance abuse and pathologic gambling might be associated with dysfunction on working memory and prefrontal activity. We hypothesized that excessive online game playing is associated with deficits in prefrontal cortex function and that recovery from excessive online game playing might improve prefrontal cortical activation in response to working memory stimulation. Methods: Thirteen adolescents with excessive online game playing (AEOP) and ten healthy adolescents (HC) agreed to participate in this study. The severity of online game play and playing time were evaluated for a baseline measurement and again following four weeks of treatment. Brain activation in response to working memory tasks (simple and complex calculations) at baseline and subsequent measurements was assessed using BOLD functional magnetic resonance imaging (fMRI). Results: Compared to the HC subjects, the AEOP participants exhibited significantly greater activity in the right middle occipital gyrus, left cerebellum posterior lobe, left premotor cortex and left middle temporal gyrus in response to working memory tasks during baseline measurements. After four weeks of treatment, the AEOP subjects showed increased activity within the right dorsolateral prefrontal cortex and left occipital fusiform gyrus. After four weeks of treatment, changes in the severity of online game playing were negatively correlated with changes in the mean b value of the right dorsolateral prefrontal cortex in response to complex stimulation. Conclusions: We suggest that the effects of online game addiction on working memory may be similar to those observed in patients with substance dependence.

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Section: Education For Online Game Playingmentioning

confidence: 99%

Changes in brain activity in response to problem solving during the abstinence from online game play

Kim¹,

Han²,

Lee³

et al. 2012

Journal of Behavioral Addictions

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“…Based on these findings, it can be speculated that genetic factors probably also influence the development of PIU. Until now, only one molecular genetics study (Lee et al, 2008) has shown the gene basis for PIU: The homozygous short allelic variant of the serotonin-transporter-linked polymorphic region (5-HTTLPR) was more frequent in the PIU group than in the control group. The knowledge is still limited about how, and whether, genetic factors affect PIU.…”

mentioning

confidence: 99%

A Twin Study of Problematic Internet Use: Its Heritability and Genetic Association With Effortful Control

Chen

et al. 2014

Twin Res Hum Genet

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Our goal was to estimate genetic and environmental sources of influence on adolescent problematic internet use, and whether these individual differences can be explained by effortful control, an important aspect of self-regulation. A sample of 825 pairs of Chinese adolescent twins and their parents provided reports of problematic internet use and effortful control. Univariate analysis revealed that genetic factors explained 58-66% of variance in problematic internet use, with the rest explained by non-shared environmental factors. Sex difference was found, suggesting boys' problematic internet use was more influenced by genetic influences than girls' problematic internet use. Bivariate analysis indicated that effortful control accounted for a modest portion of the genetic and non-shared environmental variance in problematic internet use among girls. In contrast, among boys, effortful control explained between 6% (parent report) and 20% (self-report) of variance in problematic internet use through overlapping genetic pathways. Adolescent problematic internet use is heritable, and poor effortful control can partly explain adolescent problematic internet use, with effects stronger for boys. Implications for future research are discussed.

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“…A adição à Internet é também associada com ideação suicida (Kim et al, 2006) e sintomatologia obsessiva-compulsiva (Ha et al, 2007). Inclusivamente, um estudo por Lee et al (2008), que analisa a relação entre adição à Internet e depressão através da análise de uma componente genética associada a depressão, obteve resultados que sugerem que sujeitos com adição à Internet poderão ter traços de personalidade, e de genética, similares a pacientes com depressão. Por fim, deve ter-se em consideração um estudo longitudinal conduzido por Ko et al (2007), em que os autores analisaram a baixa hostilidade e a baixa sensibilidade interpessoal como fatores potenciadores da remissão da adição à Internet e que devem ser tidos em conta na prática clínica.…”

Section: Discussionunclassified

“…A depressão é vastamente associada ao uso problemático da Internet na literatura (Jang, Hwang, & Choi, 2008;Kraut et al, 1998;Lee et al, 2008;Yen, Ko, Yen, Wu, & Yang, 2007;Yen et al, 2008). A depressão, assim como fatores associados a esta -como, por exemplo, a baixa autoestima -funcionam como fatores precipitantes da adição à Internet (Bahrainian, Haji Alizadeh, Raeisoon, Hashemi Gorji, & Khazaee, 2014).…”

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Adição à Internet: Relação Com a Sintomatologia Psicopatológica

2018

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RESUMOO presente estudo teve por objetivo averiguar as associações entre a adição à Internet e a sintomatologia psicopatológica. A amostra foi constituída por 418 participantes, entre os 18 e os 35 anos, que preencheram um questionário sociodemográfico, o Internet Addition Test, e as escalas de depressão, ansiedade, hostilidade e sensibilidade interpessoal do Brief Symptom Inventory. Foram analisadas as estruturas fatoriais e a consistências internas das escalas. Observamos que 87.8% dos participantes tinham adição leve a moderada, sendo o sexo masculino significativamente mais adicto. A adição à Internet foi positivamente associada à depressão, ansiedade, hostilidade, e sensibilidade interpessoal. Mais ainda, analisando as diferenças entre os três níveis de adição presentes na amostra foram encontradas diferenças significativas a nível da sintomatologia psicopatológica entre todos os grupos, com exceção da hostilidade. Desta forma, o nosso estudo conclui que a adição à Internet é uma problemática com associações à sintomatologia psicopatológica, realçando a necessidade de maior atenção por parte dos profissionais de saúde quanto aos hábitos desenvolvidos online e da perceção que o próprio indivíduo tem do seu grau de adição. Palavras-chave: adição à internet, sintomatologia psicopatológica, fatores sociodemográficos, população portuguesa ABSTRACTThe present study aims to corroborate associations between Internet addiction and psychopathological symptomatology. For this purpose, a sample of 418 participants, between the ages of 18 and 35, completed a sociodemographic questionnaire, the Internet Addition Test and the Brief Symptom Inventory depression, anxiety, hostility and interpersonal sensitivity scales. The factorial structures and the internal consistencies of the scales were analyzed. We observed that 87.8% of the participants had low to mild addition, being males significantly more addicted. Internet addiction was positively associated with depression, anxiety, hostility, and interpersonal sensitivity. Moreover, analyzing the differences between the three levels of addition present in the sample, we found significant differences in the psychopathological symptomatology among all groups, except for hostility. Our study concludes that Internet addiction is a problematic with associations to psychopathological symptomatology, emphasizing the need for greater attention on the part of the health professionals, regarding the habits developed online and the individual's own perception of their degree of addition.

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Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users

Cited by 159 publications

References 27 publications

Changes in brain activity in response to problem solving during the abstinence from online game play

Changes in brain activity in response to problem solving during the abstinence from online game play

A Twin Study of Problematic Internet Use: Its Heritability and Genetic Association With Effortful Control

Adição à Internet: Relação Com a Sintomatologia Psicopatológica

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