Depression is associated with worse patency and recurrent leg symptoms after lower extremity revascularization

Abstract

Depression is common among patients undergoing intervention for symptomatic PAD. After intervention, patients with depression have worse outcomes for the affected leg. Prospective analysis is required to confirm these results.

Patients with Depression are at Increased Risk for Secondary Cardiovascular Events after Lower Extremity Revascularization

“…In a separate manuscript, we reported that patients with depression at the time of PAD intervention were at increased risk for failure of the revascularization and recurrent symptoms in the treated leg. 5 To our knowledge, the present study is the first to examine the association between depression at the time of PAD intervention and mortality or subsequent cardiovascular events in other vascular beds.…”

“…[5][6][7] For patients with acute coronary syndromes, depression is a risk factor for recurrent cardiovascular events and mortality. [8][9][10] After coronary artery bypass surgery, it is associated with increased risk for recurrent cardiovascular events, 4,11 rehospitalization for cardiac events, 12 repeat coronary revascularization, 4 and death.…”

“…3,13,14 For patients with symptomatic PAD, we have previously described an association between depression and worse outcomes in the revascularized leg. 5 By multivariate analysis, patients with depression at the time of PAD revascularization were at increased risk for recurrent symptomatic PAD in the treated leg and failure of revascularization. However, this study did not address the risk for cardiovascular events in vascular territories outside the treated leg.…”

Comparison of quality of life in patients with peripheral arterial disease caused by atherosclerosis obliterans or Buerger's disease : cardiovascular topic

“…Depressive symptoms are high among patients with PAD. The presence of depression may be a helpful factor in assessing pain scales in patients with PAD 21-23. However, in our study, patients’ psychological conditions were not considered.…”

Microvascular pathology in late-life depression

“…For instance, depression at baseline was associated with worse patency of the revascularization and greater risk for return to symptomatic disease in elderly patients operated for peripheral arterial disease [19]. A recent systematic review [20] found that white matter hyperintensities (WMHs) are more common and more severe among individuals with late-life depression than in healthy controls.…”