Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly

Qiu, Wei Qiao; Sun, Xiaoyan; Selkoe, Dennis J.; Mwamburi, D. Mkaya; Huang, Tina; Bhadela, Refeeque; Bergethon, Peter R.; Scott, Tammy; Summergrad, Paul; Wang, Lixia; Rosenberg, Irwin H.; Folstein, Marshal F.

doi:10.1002/gps.1710

Cited by 52 publications

(67 citation statements)

References 35 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Qiu 15 and Sun et al 16,17 reported large sample studies of plasma Ab in elderly subjects with depression. Sun et al measured plasma Ab40 and Ab42 in elderly subjects with depression (n = 101) and without depression (n = 223) in the absence of cardiovascular disease (CVD).…”

Section: Discussionmentioning

confidence: 99%

“…Another study using 515 elderly subjects (161 depressed, 354 non-depressed) demonstrated similar results, and showed that depressive symptoms were associated with low plasma Ab42 independent of CVD in elderly subjects. 15 In that investigation, CVD was used to indicate vascular depression, 25 and the subtype of elderly subjects with depression associated with Ab was considered to show 'amyloid-associated depression' as opposed to vascular depression. More recently, the same group …”

Section: Discussionmentioning

confidence: 99%

“…14 Conversely, lower plasma Ab42 levels 15,16 and higher Ab40/42 ratio have been reported in elderly individuals with depression suggesting that 'amyloid-associated depression' may define a subtype of depression representing a prodromal manifestation of AD. 17 Although several studies concerned with Ab level in the peripheral blood of elderly subjects with depression have been reported, the results have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

“…A sandwich Ab enzyme-linked immunosorbent assay kit was used (Wako, Osaka, Japan). The Ab(1-40) kit uses the BAN50 monoclonal antibody, which specifically detects the N-terminal portion of human Ab (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), and the BA27 monoclonal antibody, which detects the C-terminal portion of Ab(1-40). The Ab(1-42) kit uses BAN50 and the BC05 monoclonal antibody, which detects the C-terminal portion of Ab(1-42).…”

Section: Serum Ab40 and Ab42 Measurementsmentioning

confidence: 99%

See 3 more Smart Citations

Serum amyloid β protein in young and elderly depression: a pilot study

et al. 2009

View full text Add to dashboard Cite

Background: Depression may increase the risk of developing Alzheimer's disease (AD). Recent large cohort studies have also shown that a low plasma amyloid b (Ab)-42 level combined with a high Ab40 level increases the risk of developing AD, suggesting plasma Ab42/40 ratio as useful for identifying risk of developing mild cognitive impairment and AD. Although several studies have examined Ab levels in the peripheral blood of elderly individuals with depression, results have been inconsistent. Furthermore, no results have been described for younger depression. Methods: Serum Ab40, Ab42 level and Ab40/42 ratio were evaluated using enzyme-linked immunosorbent assay in 60 patients with major depressive disorder (MDD) and 60 healthy controls. The results were analyzed in two age groups (young, <60 years; elderly, Ն60 years). Results: Serum Ab40 level was significantly higher in young MDD patients compared to young controls (P < 0.001), but it was not significantly deferent in the elderly group. Serum Ab42 level did not differ significantly in both young and elderly groups. Ab40/42 ratio was significantly higher in both young (P < 0.001) and elderly (P < 0.001) patients with MDD compared to controls. Conclusions: Serum Ab40/42 ratio was significantly higher in MDD patients than in controls, and this difference was seen for both elderly and young subjects. This may suggest that even young subjects with MDD undergo pathological changes in the very early stage of amyloid deposition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Serum Ab40 and Ab42 Measurementsmentioning

confidence: 99%

See 2 more Smart Citations

Serum amyloid β protein in young and elderly depression: a pilot study

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, a few data are available regarding the relationship between depression and peripheral levels of Aβ peptides. Higher levels of Aβ40, lower levels of Aβ42, and a greater Aβ40/Aβ42 ratio have been reported in elderly patients with depression, as compared with healthy control subjects [18,19,20]. Moreover, the study by Sun et al [20] highlighted how the so-called ‘amyloid-associated' depression (with high Aβ40/Aβ42 ratio) is characterized by a more severe deficit in memory, visual-spatial skills, and executive functions.…”

Section: Introductionmentioning

confidence: 99%

Plasma Amyloid-β Levels in Drug-Resistant Bipolar Depressed Patients Receiving Electroconvulsive Therapy

et al. 2013

View full text Add to dashboard Cite

Aims: Alterations of plasma amyloid-β (Aβ) peptides have been related to a high risk for cognitive impairment and dementia. The present study aimed to measure plasma Aβ peptides (Aβ40, Aβ42) and the Aβ40/Aβ42 ratio in a sample of drug-resistant bipolar depressed patients, as well as to explore the possible correlation between biological parameters and clinical changes along an electroconvulsive therapy (ECT) course. Methods: Aβ40 and Aβ42 were measured by means of an ELISA assay in 25 drug-resistant bipolar depressed patients before (T0) and 1 week after (T1) the end of ECT. The patients were clinically evaluated by means of the Hamilton Rating Scale for Depression, 21-item (HRSD-21), the Mini-Mental State Examination, and the Clinical Global Impressions-Severity of Illness Scale. Results: Plasma Aβ levels and the Aβ40/Aβ42 ratio were similar at T0 and T1. The Aβ40/Aβ42 ratio correlated positively with the HRSD total score at both T0 and T1. At T0, a negative correlation was found between the Aβ40/Aβ42 ratio and the improvement of depressive and cognitive symptoms. Moreover, remitters (n = 9; HRSD ≤10) showed a significantly lower Aβ40/Aβ42 ratio at T0 than nonremitters. Conclusion: The present data suggest that a low Aβ40/Aβ42 ratio might characterize a subgroup of depressed patients who respond to ECT, while higher values of this parameter seem to be typical of more severe cases of patients with cognitive impairment.

show abstract

Protein Binding in Patients With Late-Life Depression

Kumar¹

2011

Arch Gen Psychiatry

View full text Add to dashboard Cite

Context Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap. Objective To examine and compare protein (amyloid and tau) binding in critical brain regions in patients diagnosed as having late-life major depressive disorder (MDD) and healthy control individuals using 2-(1-{6-[(2-[18F]fluoroethyl) (methyl)-amino]-2-naphthyl}ethylidene) malononitrile ([18F]FDDNP) positron emission tomography. Design A cross-section neuroimaging study using positron emission tomography. Setting University of California, Los Angeles. Patients Our samples comprised 20 patients diagnosed as having MDD and 19 healthy control individuals of comparable age, sex, and educational level. Main Outcome Measure Relative distribution volume in regions of interest was used as the measure of [18F]FDDNP binding in all study participants. Results When compared with controls, [18F]FDDNP binding was significantly higher overall and in the posterior cingulate and lateral temporal regions in the MDD group. Conclusions These findings suggest that neuronal injury associated with higher protein load in critical brain regions might provide a mechanism in the pathophysiologic manifestation of MDD in late life and have implications for the therapeutics of depression in elderly individuals.

show abstract

Depression is associated with low plasma Aβ42 independently of cardiovascular disease in the homebound elderly

Abstract: Depressive symptoms are associated with low plasma Abeta42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Abeta42 is a separate depression subtype that could predict the onset of AD.

Cited by 52 publications

References 35 publications

Serum amyloid β protein in young and elderly depression: a pilot study

Serum amyloid β protein in young and elderly depression: a pilot study

Plasma Amyloid-β Levels in Drug-Resistant Bipolar Depressed Patients Receiving Electroconvulsive Therapy

Protein Binding in Patients With Late-Life Depression

Contact Info

Product

Resources

About