Depression is Associated with Impulse-compulsive Behaviors in Parkinson’s disease

Santos‐García, Diego; Fonticoba, Teresa de Deus; Bartolomé, Carlos Cores; Castro, Ester Suárez; Jesús, Silvia; Mir, Pablo; Pascual-Sedano, Berta; Pagonabarraga, Javier; Kulisevsky, Jaime; Hernández‐Vara, Jorge; Planellás, Lluís; Cabo, Iria; Seijo-Martínez, M; Legarda, I; Padilla, Francisco Carrillo; Caballol, Núria; Cubo, Esther; Nogueira, Víctor; Losada, Maria G. Alonso; López-Ariztegui, N; Caldentey, Juan García; Borrué, Carmen; Valero, Caridad; Alonso, Pilar Sánchez

doi:10.1016/j.jad.2020.11.075

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…This study found that the functional connectivity within the LFPN network was reduced in the PDMD and PDMSD groups compared with the PDND group. Previous studies have suggested that the dysfunction of the frontoparietal control network, especially the dorsolateral prefrontal lobe, maybe a specific brain imaging marker that identifies depression in patients with PD ( Pifl et al, 2013 ; Wen et al, 2013 ; Lou et al, 2015 ; Tucker et al, 2019 ; Santos-García et al, 2021 ). Moreover, one study identified the dorsolateral prefrontal cortex as a potential therapeutic target in patients with PD-D ( Pifl et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Resting-state brain network in Parkinson’s disease with different degrees of depression

et al. 2022

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ObjectiveThe aim of this study is to explore the neural network mechanism of Parkinson’s disease (PD) with different degrees of depression using independent component analysis (ICA) of the functional connectivity changes in the forehead, limbic system, and basal ganglia regions.MethodsA total of 106 patients with PD were divided into three groups: PD with moderate-severe depression (PDMSD, n = 42), PD with mild depression (PDMD, n = 29), and PD without depression (PDND, n = 35). Fifty gender- and age-matched healthy subjects were recruited as a control group (HC). Three-dimensional T1-weighted image and resting-state functional magnetic resonance imaging (RS-fMRI) data were collected.ResultsDifferent functional connectivity was observed in the left precentral gyrus, right precuneus, right inferior frontal gyrus, right medial and paracingulate gyrus, left supplementary motor area, right brain insula, and the inferior frontal gyrus of the left orbit among the four groups (ANOVA, P < 0.05, Voxel size > 5). Both PDMD and PDMSD exhibited increased functional connectivity in the superior-posterior default-mode network (spDMN) and left frontoparietal network (LFPN); they also exhibited a decreased functional connectivity in the interior Salience Network (inSN) when compared with the PDND group. The functional connectivity within the inSN network was decreased in the PDMSD group when compared with the PDMD group (Alphasim correction, P < 0.05, voxel size > 5).ConclusionPD with different degrees of depression has abnormal functional connectivity in multiple networks, which is an important neurobiological basis for the occurrence and development of depression in PD. The degree of decreased functional connectivity in the inSN network is related to the degree of depression in patients with PD-D, which can be an imaging marker for PD to judge the severity of depression.

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Section: Discussionmentioning

confidence: 99%

Resting-state brain network in Parkinson’s disease with different degrees of depression

et al. 2022

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“…Patient with a score <81 on the PD-CRS were considered as with cognitive impairment [ 25 , 26 ]. Patients were classified as with major depression according to the DSM-IV criteria [ 27 , 28 ]. Impulse control disorder (ICD) (pathological gambling, compulsive shopping, hypersexuality, and compulsive eating behavior) and compulsive behavior (CB) (punding, hobbyism, and dopamine dysregulation syndrome) were defined according to the previously published cutoff points of the QUIP-RS: gambling ≥6, buying ≥8, sex ≥8, eating ≥7, hobbyism–punding ≥7 [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…Patients were classified as with major depression according to the DSM-IV criteria [ 27 , 28 ]. Impulse control disorder (ICD) (pathological gambling, compulsive shopping, hypersexuality, and compulsive eating behavior) and compulsive behavior (CB) (punding, hobbyism, and dopamine dysregulation syndrome) were defined according to the previously published cutoff points of the QUIP-RS: gambling ≥6, buying ≥8, sex ≥8, eating ≥7, hobbyism–punding ≥7 [ 28 , 29 ]. For dopamine dysregulation syndrome, we accounted for the investigator’s criterion since an established cutoff does not exist [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease

Santos‐García

Laguna

Hernández‐Vara

et al. 2023

JCM

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Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.

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“…14 Another study found that depression was more frequent in patients with hobbyism/ punding than in those without. 20 PD patients with punding showed higher levels of anxiety in a different study. 22 For the role of cognition, hobbyism/punding was significantly more common in PD with dementia compared with PD without dementia, 18 whereas another study found lower Frontal Assessment Battery scores in these patients compared to controls.…”

Section: Clinical Features Of Pundingmentioning

confidence: 83%

“…One study found that punding was associated with psychiatric comorbidity (ie, psychosis, bipolar disorder) and with addictive behaviors (pathological gambling, DDS) 14 . Another study found that depression was more frequent in patients with hobbyism/punding than in those without 20 . PD patients with punding showed higher levels of anxiety in a different study 22 …”

Section: Resultsmentioning

confidence: 99%

Punding in Parkinson's Disease: An Update

Rajalingam

Fasano

2023

Movement Disord Clin Pract

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Background Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, non‐goal oriented, repetitive activity affecting individuals with Parkinson's disease (PD) on dopamine replacement therapy (DRT). Objectives In 2010, we published the first review focused on the pathophysiology of punding. This study aims to systematically review the literature of the past decade on punding in PD, particularly focusing on the clinical features, underlying pathophysiological mechanisms, and treatment. Methods Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, we searched PubMed, Embase, and APA PsycInfo for articles published between July 1, 2010 and March 19, 2022. The search strategy included: (punding) AND (parkinson*). Results Of 256 studies identified, 29 were eligible for inclusion with 19 original research articles and 10 case reports. This review confirmed that predictors of punding in PD are higher doses of DRT, younger age, male sex, and increasing disease severity. We also found an association between punding and psychiatric and/or cognitive symptoms. Neuroimaging studies have showed that punding in PD is associated with a disconnection between midbrain, limbic and white matter tracts projecting to the frontal cortices and a breakdown of the connectivity among the crucial nodes of the reward circuit. Low‐frequency repetitive transcranial magnetic stimulation on the dorsolateral prefrontal cortex has been shown to produce a transient beneficial effect in PD patients with punding. Conclusion In conclusion, although the clinical features of punding have been established, in the past 12 years, we gained a better understanding of the pathophysiological mechanisms of punding, mainly thanks to magnetic resonance imaging techniques.

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Depression is Associated with Impulse-compulsive Behaviors in Parkinson’s disease

Cited by 10 publications

References 24 publications

Resting-state brain network in Parkinson’s disease with different degrees of depression

Resting-state brain network in Parkinson’s disease with different degrees of depression

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease

Punding in Parkinson's Disease: An Update

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