Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide

Cepeda, M. Soledad; Stang, Paul; Makadia, Rupa

doi:10.4088/jcp.15m10267

Cited by 71 publications

(49 citation statements)

References 14 publications

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“…As for FeNO, the association of FeNO with depression was observed in several studies [7, 9, 10, 44]. Depression was associated with high levels of CRP and low levels of FeNO [10].…”

Section: Discussionmentioning

confidence: 99%

“…In exhalation, NO is measurable and plays an important role in the diagnosis of airway inflammation conditions such as asthma [8]. Fractional exhaled NO (FeNO) showed down-regulation in depression [9, 10]. Moreover, arginase, a key enzyme in the urea cycle, is involved in indirect regulation of NO by the consumption of L-arginine, which is a common substrate for NOS.…”

Section: Introductionmentioning

confidence: 99%

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Association of arginase I or nitric oxide-related factors with job strain in healthy workers

Oginö¹,

Itö²,

Eguchi³

et al. 2017

PLoS ONE

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This study evaluated the associations between job strain and arginase I in 378 healthy Japanese factory workers by a cross-sectional study measuring nitric oxide (NO)-related parameters (arginase I, L-arginine, exhaled nitric oxide (FeNO), and NOx), clinical parameters, and job strain using a Japanese version of the Job Content Questionnaire by Karasek. Arginase I and FEV1% were negatively correlated with job strain and positively correlated with job control and social support. FeNO and hs-CRP were negatively correlated with job strain. Multiple regression analysis showed negative association of arginase I with job strain and positive association with job control and social support in females. It is concluded that serum levels of arginase I may be useful biomarkers for the diagnosis of job stress in healthy female workers, although many factors can be influencing the data.

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“…As for FeNO, the association of FeNO with depression was observed in several studies [7, 9, 10, 44]. Depression was associated with high levels of CRP and low levels of FeNO [10].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of arginase I or nitric oxide-related factors with job strain in healthy workers

Oginö¹,

Itö²,

Eguchi³

et al. 2017

PLoS ONE

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“…Depression has been associated with higher levels of CRP [31], while a clinical study showed that CRP significantly decreased in patients with MDD after receiving anti-depressant treatments [42].…”

Section: Discussionmentioning

confidence: 99%

“…Taken together, the AA cascade, via the actions of PGs and other inflammatory cytokines, may be important not only in the pathogenesis of depressive disorders but also in the manifestation of somatic symptoms. In addition, depression has also been associated with increased levels of pro-inflammatory markers, such as C-reactive protein (CRP) [31], and MDD associated somatic symptoms have also been associated with inflammation [4] and higher levels of proinflammatory cytokines [32]. The aim of the study is to investigate the effect of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 polymorphism on somatic symptoms in MDD with a subset data from a larger study [21].…”

Section: Introductionmentioning

confidence: 99%

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Chang

Guu

Chen

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD.Eighty-two patients with MDD were assessed for their psychopathology including 2 psychiatric and somatic symptoms, BanI polymorphism of cPLA2 and COX-2 rs4648308 genotypes and CRP levels. The results revealed that MDD patients with the cPLA2 BanI GG genotypes had higher somatic symptoms and higher levels of C-reactive protein (CRP), while no differences were found among the COX-2 rs4648308 genotypes. Inflammatory process, such as arachidonic acid cascade pathway, might help explain the effect of cPLA2 BanI polymorphism on the somatic symptoms, and may be a potential target for future investigation on treatment for MDD with somatic symptoms. However, the interpretation of the findings in this study is limited since we analyzed the data from a subset data from a larger study.

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“…MDD is associated with changes in the central nervous system, immunoreactivity, and vascular reactivity, which are important in the development of the systemic inflammatory response 3 . Although the relationship between MDD and cytokines like C Reactive Protein (CRP), Interleukin-6 (IL-6), Interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α) has been revealed 4,5 , the role of inflammotory markers in etiology of MDD has not yet been clarified yet. Nowadays new, readily accessible, repeatable biological inflammatory markers have begun to be addressed in patients with MDD recently 6 .…”

Section: Introductionmentioning

confidence: 99%

Evalution Of Mean Platelet Volume, Neutrophile Lymphocyte Ratio, Platelet Lymphocyte Ratio, And Red Cell Distribution Width In Patients With Major Depressive Disorder

Gündüz¹,

Timur²,

Erzincan³

et al. 2017

MMJ

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The aim of this study was to evaluate the changes in hematologic inflammatory markers such as neutrophil /lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), red cell distribution width (RDW) and mean platelet volume (MPV) in patients with diagnosis of Major Depressive Disorder (MDD). Seventy-five patients between the ages of 18 and 75 who were not currently undergoing any psychiatric treatment and diagnosed having the first episode of MDD according to DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) ÖZ Bu çalışmanın amacı, Major Depresif Bozukluk (MDB) tanılı hastalarda Nötrofil lenfosit oranı (NLO), platelet lenfosit oranı (PLO), kırmızı küre dağılım genişliği (RDW) ortalama trombosit hacmi (MPV) gibi hematolojik inflamatuvar göstergeçlerin değerlendi-rilmesiydi. Çalışmaya Haziran 2016 ile Eylül 2016 tarihleri arasın-da Erzurum Bölge Eğitim ve Araştırma Hastanesi Psikiyatri Polikliniğine başvuran ve DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) ile ilk atak MDB tanısı alan

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Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide

Cited by 71 publications

References 14 publications

Association of arginase I or nitric oxide-related factors with job strain in healthy workers

Association of arginase I or nitric oxide-related factors with job strain in healthy workers

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Evalution Of Mean Platelet Volume, Neutrophile Lymphocyte Ratio, Platelet Lymphocyte Ratio, And Red Cell Distribution Width In Patients With Major Depressive Disorder

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