Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults

Hoogendijk, Witte J.G.; Lips, Paul; Dik, Miranda G.; Deeg, Dorly J. H.; Beekman, Aartjan T.F.; Penninx, Brenda W. J. H.

doi:10.1001/archpsyc.65.5.508

Cited by 382 publications

(285 citation statements)

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“…In the Longitudinal Aging Study Amsterdam (Hoogendijk et al, 2008), lower serum 25-hydroxyvitamin D concentrations were observed among elderly subjects with depressive symptoms than those without. In another study of Chinese populations, depressive symptoms were not associated with serum 25-hydroxyvitamin D concentrations (Pan et al, 2009).…”

Section: Discussionmentioning

confidence: 95%

“…The vitamin D receptor and the vitamin D-activating enzyme 1-a-hydroxylase are widely distributed in the human brain (Berk et al, 2007). Despite such suggestive evidence for a role of vitamin D in depression, few population-based studies have explored depressive symptoms in relation to vitamin D status (Hoogendijk et al, 2008;Pan et al, 2009). We therefore investigated the association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese employees.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season

et al. 2009

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Both depressive symptoms and vitamin D insufficiency are common during winter. This study examined the association between serum 25-hydroxyvitamin D and depressive symptoms by survey season. Subjects were 527 municipal employees aged 21-67 years of two municipal offices in Japan. Overall, there was no measurable association. However, in the workplace surveyed in November, multivariate-adjusted odds ratios (95% confidence interval) of having depressive symptoms (Center for Epidemiologic Studies Depression score of X16) for the lowest through highest quartiles of serum 25-hydroxyvitamin D were 1.00 (reference), 0.84 (0.45-1.58), 0.83 (0.44-1.58) and 0.59 (0.30-1.15), respectively (trend P ¼ 0.14). The association with the severe depressive state was more pronounced. By contrast, there was no such association in the workplace surveyed in July. Overall, this study did not provide evidence linking higher blood vitamin D levels with decreased depressive symptoms. The suggestive inverse association in sun-deprived season warrants further investigation.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season

et al. 2009

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“…PTH stimulates the increased biosynthesis of 1,25-dihydroxyvitamin D when the levels of 25(OH)D are low (38) . PTH may also contribute to depression through a possible mechanism in which low vitamin D level causes an increase in PTH level and hyperparathyroidism is often accompanied by depressive disorders (39) . Our results demonstrated that low vitamin D status was associated with higher levels of depression after adjusting for confounding variables in Malaysian women.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and depression among women from an urban community in a tropical country

Moy

Hoe

Hairi

et al. 2016

Public Health Nutr.

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Objective: To determine the association of vitamin D status with depression and health-related quality of life among women. Design: This was a cross-sectional study conducted among women in Kuala Lumpur, Malaysia. Sociodemographic characteristics, physical activity status, perceived depression and health-related quality of life were assessed via a selfadministered questionnaire. Fasting blood samples were taken for the analysis of 25-hydroxyvitamin D, parathyroid hormone, fasting blood glucose and full lipid profile. Complex samples multiple logistic regression analysis was performed. Setting: Public secondary schools in Kuala Lumpur, Malaysia. Subjects: Seven hundred and seventy female teachers were included. Results: The mean age of participants was 41·15 (95 % CI 40·51, 41·78) years and the majority were ethnic Malays. Over 70 % of them had vitamin D deficiency (<20 ng/ml or <50 nmol/l) and two-thirds were at risk for depression. In the multivariate analysis, ethnic Malays (adjusted OR (aOR) = 14·72; 95 % CI 2·12, 102·21) and Indians (aOR = 14·02; 95 % CI 2·27, 86·59), those at risk for depression (aOR = 1·88, 95 % CI 1·27, 2·79) and those with higher parathyroid hormone level (aOR = 1·13; 95 % CI 1·01, 1·26) were associated with vitamin D deficiency, while vitamin D deficiency was negatively associated with mental health-related quality of life (Mental Component Summary) scores (aOR = 0·98; 95 % CI 0·97, 0·99). Conclusions: Vitamin D deficiency is significantly associated with depression and mental health-related quality of life among women in Kuala Lumpur, Malaysia. Vitamin D deficiency is a global public health problem affecting a billion people worldwide (1) . Malaysia is a tropical country located near the equator. Being close to the equator, Malaysia enjoys abundant sunshine throughout the year. On average, Malaysia receives about 6 h of sunshine per day. With the exception of the monsoon seasons, it is extremely rare for Malaysians to have a stretch of days with completely no sunshine. However, the Malaysian population, especially the ethnic Malay and Indian women, have been found to be more susceptible to vitamin D deficiency (2,3) . The role of vitamin D is well established in Ca homeostasis and bone health (4,5) . Current evidence shows that vitamin D deficiency is also associated with increased risk for metabolic syndrome (MetS), certain types of cancer, type 2 diabetes mellitus and CVD (6,7) .Depression is one of the leading causes of disability and mortality worldwide. Globally, about 840 million people suffer from depression (8) . The National Health and Morbidity Survey (NHMS) 2011 in Malaysia reported that the prevalence of lifetime depression and current depression was 2·4 % and 1·8 %, respectively (9) , using the Mini International Neuropsychiatry Interview (MINI). Although there is a variation in the prevalence of depression using different tools, mental health problems namely depression are health conditions that should not be overlooked. Its consequences include impairment in func...

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“…Since it has recently been reported that the vitamin D receptor is distributed in the brain and 25 (OH)-vitamim D activation and the use of vitamin D in cells occur in brain organs, studies on the effects of vitamin D on mental health have been conducted [4]. In addition, vitamin D also affects the synthesis of neurotransmitters such as acetylcholine esterase, serotonin, nerve growth factor, and thyroid hormone, and it has been suggested that vitamin D may thereby affect cognitive function and depression [5].…”

Section: The Need For Researchmentioning

confidence: 99%

The Effect of Vitamin D and Calcium on Cognitive Function and Depression in the Elderly Living in a City

Lee

Kim²

2017

J Korean Acad Community Health Nurs

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Purpose: This study aims to examine the influence of vitamin D and calcium on depression and cognitive function of the elderly living alone in a city. Methods: The participants were registered in eight senior centers in S city and they had lived alone. Data were collected between November 28, 2014 and March 7, 2015. A total of 155 people participated in data collection to measure the serum vitamin D, the serum calcium, depression, and cognitive function. The data were analyzed with t-test, ANOVA, Pearson's correlation and multiple regression analysis. Results: There were significant differences in depression according to gender and perceptions of health status. Depression correlated significantly with the serum calcium and perceptions of health status, and a stepwise regression analysis showed that the perceptions of health status were significant. There were significant differences in cognitive function according to education level and age. Cognitive function correlated significantly with the serum vitamin D and a stepwise regression analysis showed that education level and age were significant. Conclusion: Consequently, elderly people with poor perceptions of their health status need a depressive intervention program and those with a higher age and lower level of education need a cognitive function intervention program.

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Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults

Abstract: The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.

Cited by 382 publications

References 32 publications

Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season

Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season

Vitamin D deficiency and depression among women from an urban community in a tropical country

The Effect of Vitamin D and Calcium on Cognitive Function and Depression in the Elderly Living in a City

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