Depression in women with polycystic ovary syndrome: clinical and biochemical correlates

Rasgon, Natalie; Rao, Rekha C.; Hwang, Sun; Altshuler, Lori L.; Elman, Shana; Zuckerbrow-Miller, Joni; Korenman, Stanley G.

doi:10.1016/s0165-0327(02)00117-9

Cited by 173 publications

(116 citation statements)

References 28 publications

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“…increased risk for diabetes). Several previous studies in women with PCOS support the role of several individual PCOS symptoms, including obesity (11,12,14,17,19), infertility (10,16,17), hirsutism (20), hyperandrogenism (15) and insulin resistance (11) in the modulation of psychological variables. The aim of this study was to explore the correlation of major PCOS symptoms with quality-of-life, psychosocial well-being and sexual satisfaction.…”

Section: Introductionmentioning

confidence: 84%

Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome

et al. 2005

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Objective: Polycystic ovary syndrome (PCOS) has been shown to cause a reduction in quality of life. This study examines the extent of different PCOS symptoms on quality-of-life, psychosocial wellbeing and sexual satisfaction. Methods: Complete metabolic, hormonal, clinical and psychosocial data were obtained from a total of 120 women with PCOS. Patients were compared with 50 healthy women to establish reductions in quality-of-life and emotional well-being. In addition, the correlation between psychosocial variables and the major clinical PCOS features obesity (body mass index (BMI)), excessive body hair (hirsutism score), acne, hyperandrogenism (serum testosterone levels), disturbed insulin regulation (area under the insulin response curve and homeostasis model assessment of insulin resistance), menstrual cycle disturbances and infertility were analyzed. Results: PCOS patients showed significant reductions in quality-of-life, increased psychological disturbances, and decreased sexual satisfaction when compared with healthy controls. BMI and hirsutism scores, but not the presence of acne, were associated with physical aspects of quality-of-life and sexual satisfaction. No clear effect of androgens or insulin resistance on psychosocial variables was detected. Similarly, the type of menstrual cycle disturbances or infertility had no impact on psychological well-being. Conclusion: In PCOS, changes in appearance, particularly obesity and hirsutism, reduce physical dimensions of quality-of-life and decrease sexual satisfaction. The role of biochemical, endocrine and metabolic parameters as well as menstrual irregularities and infertility appeared to be less important. Clinicians should pay attention to the psychosocial dimensions of PCOS on an individual basis, regardless of symptom severity or treatment response. 153 853-860 European Journal of Endocrinology

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Section: Introductionmentioning

confidence: 84%

Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome

et al. 2005

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“…In addition, our data did not include information on the female hormonal status, which together with the use of oral contraception might play an important role as confounding factor in the association between IR and depression in women. 3,8,9,19 Consequently, we could not investigate the possible influence of gender on the association under debate. Recently, Rasgon et al 19 found that in a clinical sample of women with polycystic ovary syndrome, which is characterized by hyperandrogenism and IR, 50% of the patients were considered depressed.…”

Section: Discussionmentioning

confidence: 99%

“…3,8,9,19 Consequently, we could not investigate the possible influence of gender on the association under debate. Recently, Rasgon et al 19 found that in a clinical sample of women with polycystic ovary syndrome, which is characterized by hyperandrogenism and IR, 50% of the patients were considered depressed. Further, while confirming an independent association between depression and type II diabetes, a large population-based investigation 17 suggested also that the relationship between depression and IR-related conditions (like type II diabetes, cardiovascular disease and obesity) differed between men and women.…”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms and insulin resistance in young adult males: results from the Northern Finland 1966 birth cohort

et al. 2006

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The association between insulin resistance (IR) and depression is a subject of growing research interest, especially as previous population-based studies have presented conflicting findings. The present study extends our understanding about the putative impact of the severity of depressive symptoms on this association and it provides further epidemiological evidence in support of earlier findings, suggesting that the association between IR and depression is present already in young adult males. To determine the impact of the severity of depressive symptoms on the putative association between IR and depression in young adult males, we were given access to the Northern Finland 1966 Birth Cohort database. During the 31-year follow-up survey of this genetically homogeneous birth cohort, IR was assessed by 'Qualitative Insulin Sensitivity Check Index' (QUICKI), and severity of depressive symptoms by 'Hopkins' Symptom Checklist-25' (HSCL-25). This study involved 2609 male cohort members with complete variable information. In men, the means of the QUICKI-values decreased (i.e., IR increased) in line with the increased severity of depressive symptoms as assessed by HSCL-25 subgroups (analysis of covariance P-value for trend, P = 0.003). In multivariate generalized logistic regression analyses, after adjusting for confounders, IR was positively associated with current severe depressive symptoms, the odds ratio (OR) being over threefold (adjusted OR 3.15, 95% confidence interval 1.48-6.68) and the value of OR increased in parallel with a tighter definition of IR (P-value for trend = 0.007). The results indicate that in young males, a positive association exists specifically with severe depressive symptoms. Molecular Psychiatry (2006) 11, 929-933.

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“…Al analizar la relación entre depresión y características clínicas del SOP, se señala una prevalencia de 50% en estas mujeres (27). La depresión a su vez se vió relacionada directamente con el grado de insulinorresistencia y el IMC.…”

Section: Análisis Del Temaunclassified

Calidad De Vida en Mujeres Con Síndrome De Ovario Poliquístico

2005

Rev. chil. obstet. ginecol.

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RESUMENEl síndrome de ovario poliquístico (SOP) afecta entre un 5-10% de las mujeres en edad reproductiva y constituye la endocrinopatía más frecuente de la población adolescente de nuestro país. Su diversa sintomatología puede provocar un impacto en la calidad de vida de las mujeres, lo que amenaza la identidad femenina en ellas. Esta revisión bibliográfica tiene como objetivo conocer de qué manera el SOP afecta la calidad de vida de las mujeres. La literatura señala que al comparar la calidad de vida entre mujeres sanas y con SOP, éstas últimas presentan un deterioro en diversos dominios estudiados con instrumentos generales. Al ser evaluada la calidad de vida de mujeres con SOP, por medio de un instrumento específico para dicha patología, los dominios más afectados fueron: el área de problemas menstruales, emociones y vello corporal. Investigaciones que evalúan el efecto de la sintomatología del SOP por separado en la calidad de vida de las mujeres señalan igualmente un impacto negativo. Se concluye en base a esta revisión que el SOP afecta la calidad de vida en sus diferentes dimensiones, por lo que se postula la importancia de evaluar este parámetro en las mujeres afectadas y la necesidad de que los profesionales de la salud lo consideren al momento de evaluar la intervención realizada.PALABRAS CLAVES: Síndrome de ovario poliquístico, calidad de vida SUMMARY Polycystic ovary syndrome (PCOS) has a prevalence of 5-10% in women of reproductive age, and constitutes the most frequent endocrine disease among teenagers in our country. Its very diverse clinical manifestations can impact women's quality of life, which can also be responsible of jeopardizing their female identity. The objective of this study is to know how polycystic ovary syndrome affects quality of life among women. In comparison to normal women, literature suggests that the ones suffering from PQOS appear to have a degree of deterioration in different domains studied with general instruments. The quality of life of women having PQOS was evaluated, using a specific instrument for this pathology. The domains found to be most affected were: menstrual problems, emotional aspects and body hair. Other investigations which separately evaluate clinical manifestations of PQOS from quality of life equally suggest a negative impact. Based on this study, it is concluded that PCOS affects women's quality of life in a multidimensional way, therefore its importance of evaluating this parameter in affected women. It also outlines the need of health professionals to consider this at the time of evaluating a given intervention.KEY WORDS: Polycystic ovary syndrome, quality of life Documentos

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Depression in women with polycystic ovary syndrome: clinical and biochemical correlates

Cited by 173 publications

References 28 publications

Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome

Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome

Depressive symptoms and insulin resistance in young adult males: results from the Northern Finland 1966 birth cohort

Calidad De Vida en Mujeres Con Síndrome De Ovario Poliquístico

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