Depression in type 2 diabetes: A systematic review and meta-analysis of blood inflammatory markers

Nguyen, Michelle; Perlman, George; Kim, Nakyung; Wu, Che‐Yuan; Daher, Valerie; Zhou, Angela; Mathers, Emily H.; Anita, Natasha Z.; Lanctôt, Krista L.; Herrmann, Nathan; Pakosh, Maureen; Swardfager, Walter

doi:10.1016/j.psyneuen.2021.105448

Cited by 19 publications

(17 citation statements)

References 117 publications

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“…The underlying pathophysiological mechanisms behind this bidirectional relationship between diabetes and depression are not fully elucidated but inflammatory mechanisms and insulin resistance seem to play an important role [ 4 ]. Both diabetes and depression are associated with a chronic state of systemic low-grade inflammation, and a recent meta-analysis demonstrated that the blood concentrations of C-reactive protein and interleukin-6 (IL-6) were higher in people with type 2 diabetes and comorbid depression than in patients with type 2 diabetes but without depression [ 22 ]. On the other hand, the peripheral blood concentration of brain derived neurotrophic factor (BDNF) was lower among the patients with comorbid diabetes and depression [ 22 ].…”

Section: Diabetes and Depressionmentioning

confidence: 99%

The interface of COVID-19, diabetes, and depression

et al. 2022

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Comorbid diabetes with depression is a challenging and often under-recognized clinical problem. During the current COVID-19 pandemic, a communicable disease is thriving on the increasing incidences of these non-communicable diseases. These three different health problems are bidirectionally connected forming a vicious cycle. Firstly, depressed individuals show a higher risk of developing diabetes and patients with diabetes have a higher risk of developing symptoms of depression. Secondly, patients with diabetes have a higher risk of developing severe COVID-19 as well as of experiencing breakthrough infections. Thirdly, in both patients with type 2 diabetes and in COVID-19 survivors the prevalence of depression seems to be increased. Fourthly, lockdown and quarantine measurements during the COVID-19 pandemic has led to an increase in depression. Therefore, it is of importance to increase the awareness of this interface between depression, diabetes and COVID-19. Finally, as symptoms of post-COVID, diabetes and depression may be overlapping, there is a need for educating skilled personnel in the management of these comorbidities.

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Section: Diabetes and Depressionmentioning

confidence: 99%

The interface of COVID-19, diabetes, and depression

et al. 2022

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“…Higher diol to epoxide ratios, used to estimate flux through the sEH pathway, and lower epoxides were associated with worse depression severity in this study [ 82 ]. Of note, a vast literature in psychiatry links depression to inflammatory cytokine concentrations both in people with and without T2DM [ 83 ]; however, those relationships are highly heterogeneous. In carefully matched T2DM patients, serum interleukin-6, a classical inflammatory marker, did not differ between depressed and non-depressed patients, nor was it associated with depressive symptoms, although CYP450-sEH metabolites were, suggesting that systemically, depression may be associated with an insufficient pro-resolving lipid response rather than inflammation per se [ 82 ].…”

Section: Oxylipins and Complications Of Diabetesmentioning

confidence: 99%

“…In addition to further observational clinical evidence, studies of systems physiology and mechanistic effects of diols are needed. Given that oxylipins are derived from different parent fatty acids [ 83 ], there remains a need to delineate the roles of specific species to understand overall function of the CYP450-sEH pathway in T2DM complications. This may be relevant if an approach of dietary supplementation of relevant parent fatty acids, with or without sEH inhibition, might be used with the former combination testing for potential synergistic effects [ 7 ], [ 81 ].…”

Section: Synthesis and Clinical Translationmentioning

confidence: 99%

“…Arguments against this notion rest largely on preclinical and in vitro studies, although concurrent measurement of inflammatory markers with oxylipins in one clinical study [ 82 ] and with sEH inhibition in one trial [ 98 ] suggested target engagement and that the mechanism is likely to be clinically important. Previous work has linked inflammation to multiple complications in T2DM, including cognitive decline [ 99 ], depression [ 83 ], cerebral ischemic damage [ 100 ], retinopathy [ 15 ], nephropathy [ 101 ], neuropathy [ 102 ], and cardiomyopathy [ 103 ]. In future studies, organ or disease specific markers may also be helpful to compare with oxylipins and after sEHi use in clinical studies.…”

Section: Synthesis and Clinical Translationmentioning

confidence: 99%

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Soluble Epoxide Hydrolase and Diabetes Complications

Anita

Swardfager

2022

IJMS

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Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke. T2DM also increases the risks of depression and dementia for reasons that remain largely unclear. Perturbations in the cytochrome P450-soluble epoxide hydrolase (CYP-sEH) pathway have been implicated in each of these diabetes complications. Here we review evidence from the clinical and animal literature suggesting the involvement of the CYP-sEH pathway in T2DM complications across organ systems, and highlight possible mechanisms (e.g., inflammation, fibrosis, mitochondrial function, endoplasmic reticulum stress, the unfolded protein response and autophagy) that may be relevant to the therapeutic potential of the pathway. These mechanisms may be broadly relevant to understanding, preventing and treating microvascular complications affecting the brain and other organ systems in T2DM.

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“…Untargeted metabolomics enables a comprehensive evaluation of diverse metabolite alterations, which reflect changes in metabolic pathways caused by modulation of the biological system [6]. Numerous mechanisms have been implicated in the aging process, including oxidative stress, lipid peroxidation, and the inflammatory response related to metabolic alterations [7,8]. 1 H NMR spectroscopy has high clinical significance, since metabolomic profiling can be easily conducted using peripheral tissue, plasma, fecal, and urine samples.…”

Section: Introductionmentioning

confidence: 99%

1H NMR-Based Metabolomics Reveals the Intrinsic Interaction of Age, Plasma Signature Metabolites, and Nutrient Intake in the Longevity Population in Guangxi, China

Ren

2022

Nutrients

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Health and longevity populations have distinct metabolic and nutrient intake profiles. However, the relationship between biomarkers of longevity-related metabolites and dietary nutrient intake profiles, as well as metabolic markers associated with longevity features, have not been fully elucidated. Therefore, 1H nuclear magnetic resonance (1H NMR)-based plasma metabolomics profiling was conducted in the present study to identify potential metabolites which can be used as specific markers for the evaluation of healthy aging. Plasma samples were obtained from centenarians and nonagenarians from the longevous region, and elderly participants aged 60–89 from the longevous region, as well as a low centenarian ratio region. The results showed that participants from longevous regions exhibited higher plasma levels of citrate, tyrosine, choline, carnitine, and valine, as well as lower contents of VLDL, lactate, alanine, N-acetyl glycoprotein (NAG), trimethylamine oxide (TMAO), α-glucose, β-glucose, and unsaturated lipids. The differential plasma metabolites were associated with an alteration in glycolysis/gluconeogenesis; aminoacyl-tRNA biosynthesis; alanine, aspartate, and glutamate metabolism; and phenylalanine, tyrosine, and tryptophan biosynthesis in participants from longevous regions. The signature metabolites were associated with higher dietary fiber intake, as well as lower energy and fat intake. The results of the present study demonstrate key longevity signature metabolites in plasma, and the dietary patterns identified provide a basis for further health and longevity research.

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Depression in type 2 diabetes: A systematic review and meta-analysis of blood inflammatory markers

Cited by 19 publications

References 117 publications

The interface of COVID-19, diabetes, and depression

The interface of COVID-19, diabetes, and depression

Soluble Epoxide Hydrolase and Diabetes Complications

1H NMR-Based Metabolomics Reveals the Intrinsic Interaction of Age, Plasma Signature Metabolites, and Nutrient Intake in the Longevity Population in Guangxi, China

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