Depression in Sarcoidosis

Abstract

Sarcoidosis, a chronic, multisystem disease, impacts quality of life and may increase depression risk. No previous study has reported the depression prevalence among U.S. sarcoid patients. This cross-sectional study examined sociodemographic and disease morbidity factors associated with depression. Patients diagnosed for > or = 1 yr and treated at one of six centers were eligible (n = 176); 154 completed a questionnaire of demographics, treatment, access to medical care, and a short-form Center for Epidemiologic Studies- Depression Scale (CES-D). The primary outcome variable was a CES-D score of > or = 9, indicating clinical depression. The prevalence of depression was 60%. Gender, income, access to medical care, dyspnea on exertion, and number of systems involved were associated with depression. Female sex, decreased access to medical care, and increased dyspnea predicted depression (odds ratio [OR] = 3.33, 11.64, and 2.78, respectively) after adjusting for race, income, and steroid therapy. Despite tertiary care access, patients reported medical care limitation. Health care providers must be sensitive to multiple barriers faced by chronic sarcoid patients; acknowledging depression risk and improving access to medical care will promote better overall health among sarcoid patients. Future studies of sarcoidosis will need to address depression diagnosis and treatment.

Fatigue, quality of life and health status in sarcoidosis

“…60 and 66% [1,19]. Increased dyspnoea score and number of systems involved were among the risk factors for depression [19].…”

“…Fatigue has been examined in relation to psychological factors. In a recent study, a considerable number of sarcoidosis patients were diagnosed with depression, a major symptom of which is fatigue [1,19]. In a Dutch study, patients appeared to score highly for perceived stress, which was related to fatigue, even after the role of depression was partialled out [20].…”

“…60 and 66% [1,19]. Increased dyspnoea score and number of systems involved were among the risk factors for depression [19]. Cox et al [1] found that higher scores for depressive symptoms and perceived stress were related to lower health status scores.…”

The Utility of Selected Questionnaires in the Assessment of Fatigue, Depression and Health Quality in Post-Sarcoidosis Fatigue Syndrome

“…The pathogenesis of PSFS is even more mysterious [11,12]. Depression and anxiety is frequent in patients with active sarcoidosis [12][13][14]. There are few reports pointing out the possible link between fatigue with depression.…”

Fatores preditores da qualidade de vida relacionada à saúde física e mental em pacientes com doença pulmonar intersticial: uma análise multifatorial

“…However, there have been only a few studies evaluating the impact that depression and symptoms of anxiety have on the physical and mental health-related quality of life (HRQoL) of patients with ILD. (5,6,9) The purpose of this study was to identify predictors of HRQoL in a sample of patients with ILD.…”