2014
DOI: 10.1007/s11920-014-0530-4
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Depression in HIV Infected Patients: a Review

Abstract: Depression is the most common neuropsychiatric complication in HIV-infected patients and may occur in all phases of the infection. Accurately, diagnosing major depressive disorder in the context of HIV is an ongoing challenge to clinicians and researchers, being complicated by the complex biological, psychological, and social factors associated with the HIV illness. Evidences exist to support the importance of improving the identification of depressive symptoms and their adequate treatment. Depression has long… Show more

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Cited by 378 publications
(325 citation statements)
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“…While we had sufficient statistical power to test our main hypotheses, future studies with larger sample sizes are needed to examine these associations within and between relevant groups, such as sex. For example, consistent with findings from past studies (Arseniou, Arvaniti, & Samakouri, 2014; Nanni, Caruso, Mitchell, Meggiolaro, & Grassi, 2015), we found that women had significantly higher levels of depression when compared to men. We also found differences between men and women in the severity of markers for metabolic disturbances.…”
Section: Discussionsupporting
confidence: 92%
“…While we had sufficient statistical power to test our main hypotheses, future studies with larger sample sizes are needed to examine these associations within and between relevant groups, such as sex. For example, consistent with findings from past studies (Arseniou, Arvaniti, & Samakouri, 2014; Nanni, Caruso, Mitchell, Meggiolaro, & Grassi, 2015), we found that women had significantly higher levels of depression when compared to men. We also found differences between men and women in the severity of markers for metabolic disturbances.…”
Section: Discussionsupporting
confidence: 92%
“…Although causal inferences cannot be made, our results suggest that an effective clinical management of psychological symptoms, particularly of depression and anxiety, may improve the functioning and well-being of both co-infected and mono-infected patients. The recognition and effective management of these symptoms are relevant concerns largely because of the negative effects of such symptoms on cART adherence and persistence (Gonzalez et al, 2011;Schönnesson et al, 2007;Springer et al, 2012) and the possible worsening of disease progression (Nanni et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Healthy General population 10.3% (Kessler et al, 1994) Autoimmune diseases Multiple sclerosis 23.7-50% (Marrie et al, 2015;Siegert and Abernethy, 2005) Systemic lupus 10.8-44% (Ainiala et al, 2001;Nery et al, 2007) Rheumatoid Arthritis 13-48% (Dickens et al, 2002;Matcham et al, 2014) Neurodegenerative disorders Alzheimer's disease 30-50% (Lee and Lyketsos, 2003;Zhao et al, 2016) Parkinson's disease 7-76% (Veazey et al, 2005;Bomasang-Layno et al, 2015 ) Huntington's disease 48.2% (Wetzel et al, 2011) Metabolic disorders Obesity 20-55% (Luppino et al, 2010;Stunkard et al, 2003) Cardiovascular diseases 17-27% (Rudisch and Nemeroff, 2003;Seligman and Nemeroff, 2015) Type 2 diabetes 12.8-26% (Ali et al, 2006;Anderson et al, 2001) Infection/environmental diseases Chronic obstructive pulmonary disorders 6-42% (Maurer et al, 2008) HIV 5-42% (Cruess et al, 2003;Nanni et al, 2015) Asthma 7.6-20.2% (Jiang et al, 2014) This table was adapted from Iwata et al (2013) and updated to include recent clinical findings. (Black and Miller, 2015;Fornaro et al, 2013;Hernandez et al, 2008;Huang and Lee, 2007;Leo et al, 2006;Liu et al, 2004;Maes et al, 1993;Owen et al, 2001;Simon et al, 2008) IL-1RA ↑ ↑ or ↓ (Liu et al, 2004;Maes et al, 1997;Tsai et al, 2012) IL-2 ↑ or -- (Fornaro et al, 2013;Hernandez et al, 2008;…”
Section: Table 1: Co-morbidity Of Mdd With Inflammatory Diseasesmentioning
confidence: 99%