Depression in elderly patients with Alzheimer dementia or vascular dementia and its infl uence on their quality of life

Winter, Yaroslav; Korchounov, Alexei; Zhukova, T. V.; Bertschi, Natalia

doi:10.4103/0976-3147.80087

Cited by 68 publications

(46 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NDED was also associated with functional disability but only marginally (p = 0.063) with cognitive impairment. Our results are generally consistent with previous results showing that depression is related to dementia in patients with Alzheimer's disease or vascular dementia [34,35]. …”

Section: Discussionsupporting

confidence: 83%

Emotional Disturbance in CADASIL: Its Impact on Quality of Life and Caregiver Burden

et al. 2014

View full text Add to dashboard Cite

Background and Purpose: Recurrent strokes and cognitive dysfunction are the major symptoms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). However, emotional disturbances in CADASIL patients are incompletely understood. The aim of this study was to investigate emotional disturbances in CADASIL and their impact on the patients' quality of life (QOL) and caregiver burden. Methods: From 54 patients who were diagnosed as CADASIL between January 2000 and August 2012 in the Asan Medical Center, Seoul, Korea, 23 patients were enrolled in this study. The Montgomery-Asberg Depression Rating Scale was used for the assessment of depressive emotional disturbances (DED). For nondepressive emotional disturbances (NDED), the criteria of Kim and Choi-Kwon [Neurology 2000;54:1805-1810] were used for emotional incontinence (excessive/inappropriate expression of laughing or crying), and the modified Spielberger Trait Anger Scale was used for anger proneness (excessive/inappropriate expression of anger). Patients' QOL and caregiver burden were assessed with stroke-specific emotional QOL and the Sense of Competence Questionnaire (SCQ), respectively. Functional disability was assessed by the modified Rankin scale (mRS), and white matter ischemic changes and microbleeds were analyzed using brain magnetic resonance images. Results: Twelve patients (52.2%) had various emotional disturbances including DED (n = 10, 43.5%) and NDED (n = 7, 30.4%). The presence of any emotional disturbances was associated with thalamic (p = 0.012) and cortical (p = 0.037) microbleeds, mRS (p = 0.001), cognitive impairment (p = 0.002), patients' low QOL (p = 0.009) and increased caregiver burden (p = 0.002). DED was associated with multiple (≥10) microbleeds (p = 0.039), cognitive impairment (p = 0.030) and mRS (p = 0.030), and negatively influenced all domains of patients' QOL and caregiver burden. NDED was associated with cortical microbleeds (p = 0.017) and mRS (p = 0.014). Unlike DED, NDED was not associated with patients' poor QOL, except for thinking domain, but was significantly related to total SCQ and subscales 1 and 2 of SCQ (p = 0.012). Conclusions: More than half the CADASIL patients had emotional disturbances, either DED or NDED. Both are associated with patients' poor QOL and increased caregiver burden, the former more markedly than the latter. Considering that CADASIL is a progressive disease with deteriorating patients' QOL, physicians have to pay more attention to emotional problems in CADASIL patients. Treatment strategies should be investigated in this regard to improve patients' QOL and reduce caregiver burden.

show abstract

Section: Discussionsupporting

confidence: 83%

Emotional Disturbance in CADASIL: Its Impact on Quality of Life and Caregiver Burden

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Nevertheless, besides mortality, depression indirectly affects the quality of life of the patients and their families [45, 46] and therefore must be detected and treated early on among patients with dementia.…”

Section: Discussionmentioning

confidence: 99%

Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia

Petersen

Waldorff

Siersma

et al. 2017

International Journal of Alzheimer's Disease

View full text Add to dashboard Cite

Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline. During the 3-year follow-up period, 56 patients died, and, among them, 12 were with MD-S at baseline. Multivariable analysis adjusting for the potential confounders (age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, QoL-AD, NPIQ, ADSC-ADL, medication, and RCT allocation) showed that patients with MD-S had a 2.5-fold higher mortality as compared to the patients without or with only few depressive symptoms. Our result revealed that depression is possibly associated with increased mortality in patients with mild dementia. Given that depression is treatable, screening for depression and treatment of depression can be important already in the earliest stage of dementia to reduce mortality.

show abstract

“…In order not to disturb derange older participants longer than necessary, the EQ-5D seemed to be an appropriate measure. It has been widely used in older populations [27][28][29]. Measuring GQoL was challenging.…”

Section: Discussionmentioning

confidence: 99%

Oral Health and Quality of Life in Old Age: A Cross-Sectional Pilot Project in Germany and Poland

Skośkiewicz−Malinowska¹,

Noack²,

Kaderali

et al. 2016

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. The process of ageing influences all dimensions of social life and personal well-being, but the influence of health on different dimensions of quality of life (QoL) among the elderly is rarely examined. Objectives. The aim of the pilot study is to test the feasibility of a comprehensive study design to evaluate general and dental health as well as QoL in a bi-national sample. In addition, this pilot study should allow for the exploration of potential interactions between QoL, socioeconomic, health and oral health variables. Material and Methods. Individuals aged 64 years and older (n = 100) from university dental clinics of the Wroclaw Medical University, Poland (n = 50) and of the University Hospital in Dresden, Germany (n = 50) were examined. The oral health status of participants was assessed by clinical examination. Socio-demographic, environmental and general health status were evaluated during the medical interview. General quality of life (GQoL) was assessed by an overall question with a visual analogue scale (VAS) from -5 (worst) to +5 (best). Health-related quality of life (HRQoL) and oral health-related quality of life (OHRQoL) were measured with the EQ-5D and OHIP-14 questionnaires. Statistical analyses comprised Pearson's c 2 test, Wilcoxon test, linear regression model for statistical analysis and different multivariate linear regression analyses. Results. For the GQoL-VAS-Score the results for QoL measurements were 1.22 ± 2.62 (x -± SD), for EQ-5D-Score 7.45 ± 2.25 (x -± SD), and for OHIP-14-ADD-Score 11.04 ± 13.56 (x -± SD). Differences between Polish and German populations were observed. Conclusions. The study design proved to be feasible for a senior population. The overall GQoL question, EQ-5D and OHIP-14 were regarded as appropriate instruments. Subjective and objective (oral) health measures showed differences between Germany and Poland. For methodological reasons, these differences are not generalizable, but of value for study hypotheses in larger samples (Adv Clin Exp Med 2016, 25, 5, 951-959).

show abstract

Depression in elderly patients with Alzheimer dementia or vascular dementia and its infl uence on their quality of life

Cited by 68 publications

References 24 publications

Emotional Disturbance in CADASIL: Its Impact on Quality of Life and Caregiver Burden

Emotional Disturbance in CADASIL: Its Impact on Quality of Life and Caregiver Burden

Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia

Oral Health and Quality of Life in Old Age: A Cross-Sectional Pilot Project in Germany and Poland

Contact Info

Product

Resources

About