Depression in Childhood Asthma vs. Adult-Onset Asthma: A Cross-Sectional Study from the National Health and Nutrition Examination Survey (NHANES)

Abstract

Background: asthma, a chronic respiratory disease caused by inflammation and narrowing of the small airways in the lungs, is the most common chronic childhood disease. Prevalence of childhood asthma in the United States is 5.8%. In boys, prevalence is 5.7% and it is 6% in girls. Asthma is associated with other comorbidities such as major depressive disorder and anxiety disorder. This study explores the association between asthma and depression. Methods: we conducted a retrospective cross-sectional study using NHANES data from 2013 to 2018. Asthma and childhood onset asthma were assessed using questionnaires MCQ010 and MCQ025, respectively. Sociodemographic variables were summarized, and univariate analysis was performed to determine the association between asthma and major depressive disorder and its individual symptoms. Results: there were 402,167 participants from 2013–2018 in our study: no asthma in 84.70%; asthma in 15.30%. Childhood onset asthma (COA) included 10.51% and adult-onset asthma (AOA) included 4.79%. Median age of COA is 5 years and AOA is 41 years. Among the asthma groups, most AOA were females (67.77%, p < 0.0001), most COA were males (52.16%, p < 0.0001), and ethnicity was predominantly White in AOA (42.39%, p < 0001) and in COA (35.24%, p < 0.0001). AOA mostly had annual household income from $0–24,999 (35.91%, p < 0.0001), while COA mostly had annual household income from $25,000–64,999 (36.66%, p < 0.0001). There was a significantly higher prevalence of MDD in COA (38.90%) and AOA (47.30%) compared to NOA (31.91%). Frequency of symptoms related to MDD were found to have a significantly higher prevalence and severity in the asthma groups compared to no asthma, and slightly greater and more severe in AOA than in COA. Symptoms include having little interest in doing things (COA 18.38% vs. AOA 22.50% vs. NOA 15.44%), feeling down, depressed, or hopeless (COA 20.05% vs. AOA 22.77% vs. NOA 15.85%), having trouble sleeping or sleeping too much (COA 27.38% vs. AOA 23.15% vs. NOA 22.24%), feeling tired or having little energy (COA 39.17% vs. AOA 34.24% vs. NOA 33.97%), having poor appetite or overeating (COA 19.88% vs. AOA 20.02% vs. NOA 15.11%), feeling bad about yourself (COA 13.90% vs. AOA 13.79% vs. NOA 10.78%), having trouble concentrating on things (COA 12.34% vs. AOA 14.41% vs. NOA 10.06%), moving or speaking slowly or too fast (COA 8.59% vs. AOA 9.72% vs. NOA 6.09%), thinking you would be better off dead (COA 3.12% vs. AOA 4.38% vs. NOA 1.95%) and having the difficulties these problems have caused (COA 21.66% vs. AOA 26.73% vs. NOA 19.34%, p < 0.0001). Conclusion: MDD and related symptoms were significantly higher and more severe in participants with asthma compared to no asthma. Between adult-onset asthma compared to childhood onset asthma, adult-onset asthma had slightly greater and more severe MDD and related symptoms compared to childhood onset asthma.

Interaction between Serum Cotinine and Magnesium Intake with Childhood Asthma: A Cross-Sectional Study

“…The NHANES database is a nationally representative survey implemented by the National Center for Health Statistics (NCHS) and the Centers for Disease Control and Prevention (CDC). The survey combines interviews (which include demographic, socioeconomic, dietary, and health-related questions) and physical examinations (which contain medical, dental, and physiological measurements, as well as laboratory tests) [15, 16]. All NHANES participants provided written consent to participate in the survey, and data collection was approved by the NCHS Research Ethics Review Committee.…”

Experience of using omalizumab in patients with severe bronchial asthma

“…Вероятно, этим объясняется хороший ответ на терапию омализумабом в нашем исследовании. Депрессия и тревожные расстройства часто встречаются при БА и влияют на качество жизни пациента [22]. У больных астмой в два раза чаще развиваются депрессивные симптомы по сравнению лицами без астмы [23].…”

“…Люди с депрессией имеют повышенный уровень провоспалительных цитокинов, IL-1, IL-4, IL-6, TNF-альфа, которые играют решаю щую роль в астме. Цитокины, такие как IL-1, IL-6 и TNF-α, могут усиливать ранние стадии воспалительной реакции и вызывать значительное воспаление при астме [22][23][24][25]. Имеются данные, свидетельствующие о том, что тревожные расстройства могут увеличить риск атопии или аллергической астмы, что связано с увеличением тяжести астмы [26].…”

“…Пациенты с астмой с генерализованным тревожным расстройством испытывают больше трудностей с принятием соответствующих решений по самоконтролю, что влияет на контроль астмы и качество жизни по сравнению с пациентами с астмой без этого расстройства. Кроме того, симптомы как тревоги, так и астмы включают одышку, стеснение в груди и сердце биение, что может привести к неправильной интерпретации симптомов, чрезмерному использованию бронходилататоров и их побочным эффектам [22][23][24][25][26][27].…”

Use of feature importance statistics to accurately predict asthma attacks using machine learning: A cross-sectional cohort study of the US population

“…However, predicting the risk of an asthma attack is currently a largely qualitative process, and there is no widely used algorithm to help identify patients at risk [6]. Most studies on the subject have used univariate regression modeling to identify risk factors for asthma attacks, which do not determine the predictive performance of an optimal combination of factors in individual patients [7][8][9][10][11][12][13][14][15].…”