Depression in Alzheimer’s Disease: Epidemiology, Mechanisms, and Treatment

Huang, Yu-Yuan; Gan, Yi-Han; Yang, Liu; Cheng, Wei; Yu, Jin-Tai

doi:10.1016/j.biopsych.2023.10.008

Cited by 3 publications

(1 citation statement)

References 125 publications

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“…Alzheimer’s disease (AD) is the prevailing form of dementia, primarily distinguished by three prominent syndromes: diminished cognitive function [ 1, 2 ], impaired daily living capacity [ 3 ], and mental behavioral abnormalities [ 4 ]. These manifestations significantly impact the physical and mental well-being as well as the overall quality of life experienced by affected individuals.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Microcirculation at Acupoints in vivo of Alzheimer’s Disease Animal Model with Photoacoustic Microscope: A Pilot Study

Jiang,

Wang,

et al. 2024

ADR

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Background: Alzheimer’s disease may be effectively treated with acupoint-based acupuncture, which is acknowledged globally. However, more research is needed to understand the alterations in acupoints that occur throughout the illness and acupuncture treatment. Objective: This research investigated the differences in acupoint microcirculation between normal mice and AD animals in vivo. This research also examined how acupuncture affected AD animal models and acupoint microcirculation. Methods: 6-month-old SAMP8 mice were divided into two groups: the AD group and the acupuncture group. Additionally, SAMR1 mice of the same month were included as the normal group. The study involved subjecting a group of mice to 28 consecutive days of acupuncture at the ST36 (Zusanli) and CV12 (Zhongwan) acupoints. Following this treatment, the Morris water maze test was conducted to assess the mice’s learning and memory abilities; the acoustic-resolution photoacoustic microscope (AR-PAM) imaging system was utilized to observe the microcirculation in CV12 acupoint region and head-specific region of each group of mice. Results: In comparison to the control group, the mice in the AD group exhibited a considerable decline in their learning and memory capabilities (p < 0.01). In comparison to the control group, the vascular in the CV12 region and head-specific region in mice from the AD group exhibited a considerable reduction in length, distance, and diameter r (p < 0.01). The implementation of acupuncture treatment had the potential to enhance the aforementioned condition to a certain degree. Conclusions: These findings offered tangible visual evidence that supports the ongoing investigation into the underlying mechanisms of acupuncture’s therapeutic effects.

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Section: Introductionmentioning

confidence: 99%

Visualization of Microcirculation at Acupoints in vivo of Alzheimer’s Disease Animal Model with Photoacoustic Microscope: A Pilot Study

Jiang,

Wang,

et al. 2024

ADR

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Depressive Symptoms and Plasma Markers of Alzheimer's Disease and Neurodegeneration: A Coordinated Meta-Analysis of 8 Cohort Studies

Twait,

Kamarioti,

Verberk

et al. 2024

The American Journal of Geriatric Psychiatry

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Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Li,

Hu,

Zhang

et al. 2024

Alz Res Therapy

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Background Cardiometabolic multimorbidity is associated with an increased risk of dementia, but the pathogenic mechanisms linking them remain largely undefined. We aimed to assess the associations of cardiometabolic multimorbidity with cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) pathology to enhance our understanding of the underlying mechanisms linking cardiometabolic multimorbidity and AD. Methods This study included 1464 cognitively intact participants from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) database. Cardiometabolic diseases (CMD) are a group of interrelated disorders such as hypertension, diabetes, heart diseases (HD), and stroke. Based on the CMD status, participants were categorized as CMD-free, single CMD, or CMD multimorbidity. CMD multimorbidity is defined as the coexistence of two or more CMDs. The associations of cardiometabolic multimorbidity and CSF biomarkers were examined using multivariable linear regression models with demographic characteristics, the APOE ε4 allele, and lifestyle factors as covariates. Subgroup analyses stratified by age, sex, and APOE ε4 status were also performed. Results A total of 1464 individuals (mean age, 61.80 years; age range, 40–89 years) were included. The markers of phosphorylated tau-related processes (CSF P-tau181: β = 0.165, P = 0.037) and neuronal injury (CSF T-tau: β = 0.065, P = 0.033) were significantly increased in subjects with CMD multimorbidity (versus CMD-free), but not in those with single CMD. The association between CMD multimorbidity with CSF T-tau levels remained significant after controlling for Aβ42 levels. Additionally, significantly elevated tau-related biomarkers were observed in patients with specific CMD combinations (i.e., hypertension and diabetes, hypertension and HD), especially in long disease courses. Conclusions The presence of cardiometabolic multimorbidity was associated with tau phosphorylation and neuronal injury in cognitively normal populations. CMD multimorbidity might be a potential independent target to alleviate tau-related pathologies that can cause cognitive impairment.

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Depression in Alzheimer’s Disease: Epidemiology, Mechanisms, and Treatment

Cited by 3 publications

References 125 publications

Visualization of Microcirculation at Acupoints in vivo of Alzheimer’s Disease Animal Model with Photoacoustic Microscope: A Pilot Study

Visualization of Microcirculation at Acupoints in vivo of Alzheimer’s Disease Animal Model with Photoacoustic Microscope: A Pilot Study

Depressive Symptoms and Plasma Markers of Alzheimer's Disease and Neurodegeneration: A Coordinated Meta-Analysis of 8 Cohort Studies

Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

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