Depression in Adolescence and Brain-Derived Neurotrophic Factor

Lee, Bo-Young; Shin, Eunjin; Song, Inwoong; Chang, Bomi

doi:10.3389/fnmol.2022.947192

Cited by 9 publications

(10 citation statements)

References 93 publications

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“…Regarding the BDNF serum levels, our results with adequate power indicate no significant correlations between the BDNF peripheral level and depressive symptoms in adolescent girls, which is in line with some of the previous reports on this subject [ 44 , 45 , 46 ]. However, our results remain in contrast with most studies on BDNF serum levels in the adult population, in which a decrease in serum BDNF has been widely associated with the presence of depressive symptoms [ 15 , 33 , 47 ]. It could be possible that a decrease in the BDNF serum level characterizes depression later in life, while it is not so evident in the developmental age.…”

Section: Discussioncontrasting

confidence: 99%

Biomarkers of Depression among Adolescent Girls: BDNF and Epigenetics

Zwolińska,

Bilska,

Tarhonska

et al. 2024

IJMS

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Alterations in brain-derived neurotrophic factor (BDNF) expression have been suggested to mediate the influence of environmental factors on the emergence of depression through epigenetic modifications. However, research on this subject in the developmental population is lacking and the pathophysiology of adolescent depression remains unclear. We aimed to investigate the alterations in BDNF expression and global DNA methylation in depression among adolescent girls. Thirty female inpatients with the initial diagnosis of depression were assessed before and after the period of antidepressant treatment and compared with thirty age-matched healthy controls. The assessment involved BDNF and proBDNF serum levels, the BDNF gene exon IV promoter methylation, and global DNA methylation. The methylation level in the BDNF gene exon IV promoter was significantly lower in the studied group compared with the control and correlated negatively with the severity of depression. The test distinguished the studied group from the controls with a sensitivity of 37% and specificity of 90%. The differences were no longer present after the period of antidepressant treatment. No differences in the global DNA methylation, BDNF, and proBDNF levels were found. We concluded that decreased methylation in the BDNF exon IV promoter could be considered as a biomarker of a depression state among adolescent girls.

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Section: Discussioncontrasting

confidence: 99%

Biomarkers of Depression among Adolescent Girls: BDNF and Epigenetics

Zwolińska,

Bilska,

Tarhonska

et al. 2024

IJMS

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“…Neurogenesis defects in the hippocampus are associated with depression-related symptoms, such as hopelessness and helplessness ( Anacker and Hen, 2017 ; Gomes-Leal, 2021 ). A growing body of research now shows that impaired neurogenesis alters a spectrum of physiological processes, such as the hypothalamic-pituitary-adrenal axis, inflammation, and neurotrophic factors ( Cao et al., 2021 ; Lee et al., 2022 ), which are all critical to stress responses or depression. In addition, the effects of antidepressants were not sensitive to the defective neurogenesis; thus, it is difficult for drugs to play a useful role in depression.…”

Section: Discussionmentioning

confidence: 99%

MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice

Zheng,

Sheng,

Jin

et al. 2023

International Journal of Neuropsychopharmacology

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Background Depression is a neuropsychiatric disease with a high disability rate and mainly caused by the chronic stress or genetic factors. There is increasing evidence that microRNAs (miRNAs) play a critical role in the pathogenesis of depression. However, the underlying molecular mechanism for the pathophysiology of depression of miRNA remains entirely unclear so far. Methods We first established a chronic social defeat stress (CSDS) mice model of depression, and depression-like behaviors of mice were evaluated by a series of behavioral tests. Next, we detected several abundantly expressive miRNAs suggested in previous reports to be involved in depression and found miR-182-5p was selected as a candidate for analysis in the hippocampus. Then western blotting and immunofluorescence were used together to examine whether adeno-associated virus (AAV)-siR-182-5p treatment alleviated chronic stress–induced decrease in hippocampal Akt/GSK3β/cAMP-response element binding protein (CREB) signaling pathway and increase in neurogenesis impairment and neuroinflammation. Furthermore, CREB inhibitor was adopted to examine if blockade of Akt/GSK3β/CREB signaling pathway abolished the antidepressant actions of AAV-siR-182-5p in mice. Results Knockdown of miR-182-5p alleviated depression-like behaviors and impaired neurogenesis of CSDS-induced mice. Intriguingly, the usage of agomiR-182-5p produced significant increases in immobility times and aggravated neuronal neurogenesis damage of mice. More importantly, it suggested that 666-15 blocked the reversal effects of AAV-siR-182-5p on the CSDS-induced depressive-like behaviors in behavioral testing and neuronal neurogenesis within hippocampus of mice. Conclusions These findings indicated that hippocampal miR-182-5p/Akt/GSK3β/CREB signaling pathway participated in the pathogenesis of depression, and it might give more opportunities for new drug developments based on the miRNA target in the clinic.

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“…The alteration of BDNF levels, as well as the imbalance between pro-BDNF and m-BDNF, and deficits in BDNF signaling are associated with the pathogenesis of various neurologic and psychiatric disorders, including depressive disorder, schizophrenia, and bipolar disorder [ 8 , 11 , 23 , 38 , 39 , 40 , 41 ].…”

Section: Clinical Correlationsmentioning

confidence: 99%

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder

Shkundin,

Halaris

2023

JPM

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Brain-Derived Neurotrophic Factor (BDNF) is crucial for various aspects of neuronal development and function, including synaptic plasticity, neurotransmitter release, and supporting neuronal differentiation, growth, and survival. It is involved in the formation and preservation of dopaminergic, serotonergic, GABAergic, and cholinergic neurons, facilitating efficient stimulus transmission within the synaptic system and contributing to learning, memory, and overall cognition. Furthermore, BDNF demonstrates involvement in neuroinflammation and showcases neuroprotective effects. In contrast, BDNF antisense RNA (BDNF-AS) is linked to the regulation and control of BDNF, facilitating its suppression and contributing to neurotoxicity, apoptosis, and decreased cell viability. This review article aims to comprehensively overview the significance of single nucleotide polymorphisms (SNPs) in BDNF/BDNF-AS genes within psychiatric conditions, with a specific focus on their associations with depression, schizophrenia, and bipolar disorder. The independent influence of each BDNF/BDNF-AS gene variation, as well as the interplay between SNPs and their linkage disequilibrium, environmental factors, including early-life experiences, and interactions with other genes, lead to alterations in brain architecture and function, shaping vulnerability to mental health disorders. The potential translational applications of BDNF/BDNF-AS polymorphism knowledge can revolutionize personalized medicine, predict disease susceptibility, treatment outcomes, and guide the selection of interventions tailored to individual patients.

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Depression in Adolescence and Brain-Derived Neurotrophic Factor

Cited by 9 publications

References 93 publications

Biomarkers of Depression among Adolescent Girls: BDNF and Epigenetics

Biomarkers of Depression among Adolescent Girls: BDNF and Epigenetics

MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder

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