Depression assessed over 1‐year survival in patients with myocardial infarction

Sørensen, Claus; Brandes, Axel; Hendricks, Oliver; Thrane, J.; Friis-Hasché, E; Haghfelt, Torben; Bech, Per

doi:10.1111/j.1600-0447.2006.00777.x

Cited by 19 publications

(8 citation statements)

References 31 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only eight studies [26]–[33] provided adjusted estimates and they were too heterogeneous to pool into a common estimate. In these studies, the estimates were on average 21% lower after adjustment for cardiac disease severity and comorbidity.…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms and Risk of New Cardiovascular Events or Death in Patients with Myocardial Infarction: A Population-Based Longitudinal Study Examining Health Behaviors and Health Care Interventions

et al. 2013

View full text Add to dashboard Cite

BackgroundDepressive symptoms is associated with adverse cardiovascular outcomes in patients with myocardial infarction (MI), but the underlying mechanisms are unclear and it remains unknown whether subgroups of patients are at a particularly high relative risk of adverse outcomes. We examined the risk of new cardiovascular events and/or death in patients with depressive symptoms following first-time MI taking into account other secondary preventive factors. We further explored whether we could identify subgroups of patients with a particularly high relative risk of adverse outcomes.Methods and ResultsWe conducted a prospective population-based cohort study of 897 patients discharged with first-time MI between 1 January 2009 and 31 December 2009, and followed up until 31 July 2012. Depressive symptoms were found in 18.6% using the Hospital Anxiety and Depression Scale (HADS-D≥8). A total of 239 new cardiovascular events, 95 deaths, and 288 composite events (239 new cardiovascular events and 49 deaths) occurred during 1,975 person-years of follow-up. Event-free survival was evaluated using Cox regression analysis. Compared to the 730 patients without depressive symptoms (HADS-D<8), the 167 patients with depressive symptoms (HADS-D≥8) had age- and sex-adjusted hazard ratios [HR] (95% confidence interval [CI]) of 1.53 (95% CI, 1.14–2.05) for a new cardiovascular event, 3.10 (95% CI, 2.04–4.71) for death and 1.77 (95% CI, 1.36–2.31) for a composite event. The associations were attenuated when adjusted for disease severity, comorbid conditions and physical inactivity; HR = 1.17 (95% CI, 0.85–1.61) for a new cardiovascular event, HR = 2.01 (95% CI, 1.28–3.16) for death, and HR = 1.33 (95% CI, 1.00–1.76) for a composite event. No subgroups of patients had a particularly high risk of adverse outcomes.ConclusionsDepressive symptoms following first-time MI was an independent prognostic risk factor for death, but not for new cardiovascular events. We found no subgroups of patients with a particularly high relative risk of adverse outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms and Risk of New Cardiovascular Events or Death in Patients with Myocardial Infarction: A Population-Based Longitudinal Study Examining Health Behaviors and Health Care Interventions

et al. 2013

View full text Add to dashboard Cite

show abstract

“…61,62 Another 60 found that the association was signifi cant for older (older than 65 years) but marginal for younger patients. Studies of similar methodological quality published since the EPC report have shown relations between post-MI depression symptoms and hospital readmission 21,26,29 and nonfatal cardiac events or symptoms. 8,13 Two adequately powered studies 26,29 did not support the relation between depression and nonfatal events.…”

Section: Evidence Question 2: What Is the Prevalence Of Continued Depmentioning

confidence: 95%

AAFP Guideline for the Detection and Management of Post-Myocardial Infarction Depression

2009

The Annals of Family Medicine

View full text Add to dashboard Cite

“…Sorensen et al. (4), in this issue, assessed depression over the course of 1 year in patients with an episode of myocardial infarction (MI), including non‐Q‐wave (intramural) MI and Q‐wave (transmural) MI. Of a total of 763 patients who had been admitted to 17 Danish hospitals for MI, 73 (9.6%) fulfilled ICD‐10 criteria for depression at discharge from the index hospitalization, based on their responses to the major depression inventory, a self‐administered questionnaire for depression with proven reliability for detecting a diagnosis of depression.…”

Section: Introductionmentioning

confidence: 99%

“…The depression‐positive group was more likely to require re‐hospitalization during the 1‐year study period, although they were no more likely than their non‐depressed counterparts to have another acute coronary event. Severity of depression – mild, moderate, or severe – did not separate by sex, age, or cardiovascular risk profile but was associated with increased mortality (4). The relative risk (RR) was 3.2 for death during the 1‐year follow‐up compared with patients without depression at index discharge.…”

Section: Introductionmentioning

confidence: 99%