Abstract:Objective:
This study aimed to determine the frequency of depression in postmenopausal women, examine some variables that are thought to be related, and evaluate the relationships between postmenopausal depression, anxiety, and fear of death.
Methods:
The study is a cross-sectional study conducted among postmenopausal women who applied to an Obstetrics and Gynecology Polyclinic in Sakarya, Turkey, between March and September 2018. The study group consis… Show more
“…17 In a study conducted on postmenopausal women in Turkey, the prevalence of depression was reported as 41%. 28 Although the incidence of depression in our study was lower than in China and higher than in the rest of the world, it was similar to the prevalence of depression in premenopausal and postmenopausal periods. The different results reported in various studies include the non-standardisation of the diagnostic methods used in the studies and the other socio-economic and cultural characteristics of the people who make up the study populations.…”
Section: Discussionsupporting
confidence: 54%
“…In a database‐based study in Australia, depressive symptoms ranged between 22% and 25% 17 . In a study conducted on postmenopausal women in Turkey, the prevalence of depression was reported as 41% 28 . Although the incidence of depression in our study was lower than in China and higher than in the rest of the world, it was similar to the prevalence of depression in premenopausal and postmenopausal periods.…”
Section: Discussioncontrasting
confidence: 42%
“…Depression in perimenopausal and postmenopausal periods is significant as a significant public health problem, particularly for social and mental health. [26][27][28] Although there are various studies on the mental status of women in the pre-and postmenopausal period in Turkey, this study will make an essential contribution to illuminating the menopausal period since the depression, social support and QOL are evaluated together.…”
Background
This study aimed to determine the prevalence of depression in perimenopausal and postmenopausal women in a semi‐rural area in a city in Turkey and to evaluate perceived social support and quality of life by examining some of the variables thought to be related.
Methods
The study was conducted on 827 perimenopausal and postmenopausal women aged 40–60 years. The questionnaire included sociodemographic characteristics, some variables associated with depression, questions from the Beck Depression Inventory, Multidimensional Scale of Perceived Social Support, and European Health Impact Scale ‐ Quality of Life‐8 (EUROHIS‐QOL‐8) scale.
Results
The prevalence of depression was 23.1% (n = 191) in the study. The prevalence of depression was found to be higher in single/widowed/separated individuals (odds ratio (OR): 2.539; 95% CI: 1.593–4.047) and at poor income levels (1.980; 1.000–3.021). The frequency of depression was found to be lower in those who gave birth once or twice (0.470; 0.294–0.752), those with a high level of social support (0.959; 0.948–0.971), and those with a high level of QOL (0.836; 0.794–0.879). There was a moderate negative correlation between the depression scale and QOL scale scores (r = −0.405, P = 0.001). A weak negative correlation was found between depression and social support scores (r = −0.383, P = 0.001).
Conclusion
Women are more vulnerable to depression in premenopausal and postmenopausal periods. Being single/widowed, having a poor income level, having low social support, and low QOL are important risk factors which increase the frequency of depression.
“…17 In a study conducted on postmenopausal women in Turkey, the prevalence of depression was reported as 41%. 28 Although the incidence of depression in our study was lower than in China and higher than in the rest of the world, it was similar to the prevalence of depression in premenopausal and postmenopausal periods. The different results reported in various studies include the non-standardisation of the diagnostic methods used in the studies and the other socio-economic and cultural characteristics of the people who make up the study populations.…”
Section: Discussionsupporting
confidence: 54%
“…In a database‐based study in Australia, depressive symptoms ranged between 22% and 25% 17 . In a study conducted on postmenopausal women in Turkey, the prevalence of depression was reported as 41% 28 . Although the incidence of depression in our study was lower than in China and higher than in the rest of the world, it was similar to the prevalence of depression in premenopausal and postmenopausal periods.…”
Section: Discussioncontrasting
confidence: 42%
“…Depression in perimenopausal and postmenopausal periods is significant as a significant public health problem, particularly for social and mental health. [26][27][28] Although there are various studies on the mental status of women in the pre-and postmenopausal period in Turkey, this study will make an essential contribution to illuminating the menopausal period since the depression, social support and QOL are evaluated together.…”
Background
This study aimed to determine the prevalence of depression in perimenopausal and postmenopausal women in a semi‐rural area in a city in Turkey and to evaluate perceived social support and quality of life by examining some of the variables thought to be related.
Methods
The study was conducted on 827 perimenopausal and postmenopausal women aged 40–60 years. The questionnaire included sociodemographic characteristics, some variables associated with depression, questions from the Beck Depression Inventory, Multidimensional Scale of Perceived Social Support, and European Health Impact Scale ‐ Quality of Life‐8 (EUROHIS‐QOL‐8) scale.
Results
The prevalence of depression was 23.1% (n = 191) in the study. The prevalence of depression was found to be higher in single/widowed/separated individuals (odds ratio (OR): 2.539; 95% CI: 1.593–4.047) and at poor income levels (1.980; 1.000–3.021). The frequency of depression was found to be lower in those who gave birth once or twice (0.470; 0.294–0.752), those with a high level of social support (0.959; 0.948–0.971), and those with a high level of QOL (0.836; 0.794–0.879). There was a moderate negative correlation between the depression scale and QOL scale scores (r = −0.405, P = 0.001). A weak negative correlation was found between depression and social support scores (r = −0.383, P = 0.001).
Conclusion
Women are more vulnerable to depression in premenopausal and postmenopausal periods. Being single/widowed, having a poor income level, having low social support, and low QOL are important risk factors which increase the frequency of depression.
“…GABA reduction has been observed in perimenopausal and postmenopausal women (Wang et al, 2016(Wang et al, , 2019, which correlates with higher FM prevalence in women and its connection with climacteric symptoms (Carranza-Lira & Hernandez, 2014). From this point of view, FM seems to be part of a series of neurological disorders showing perimenopausal prevalence and correlation with gonadal hormone alterations, such as migraine, central vestibular problems, anxiety, and depression (Loder et al, 2007;Mucci et al, 2018;Ozdemir et al, 2020). Various interrelationships between steroid hormones and the GABAergic function have emerged from different studies.…”
Fibromyalgia (FM) is an unsolved central pain processing disturbance. We aim to provide a unifying model for FM pathogenesis based on a loop network involving thalamocortical regions, i.e., the ventroposterior lateral thalamus (VPL), the somatosensory cortex (SC), and the thalamic reticular nucleus (TRN). The dynamics of the loop have been described by three differential equations having neuron mean firing rates as variables and containing Hill functions to model mutual interactions among the loop elements. A computational analysis conducted with MATLAB has shown a transition from monostability to bistability of the loop behavior for a weakening of GABAergic transmission between TRN and VPL. This involves the appearance of a high-firing-rate steady state, which becomes dominant and is assumed to represent pathogenic pain processing giving rise to chronic pain. Our model is consistent with a bulk of literature evidence, such as neuroimaging and pharmacological data collected on FM patients, and with correlations between FM and immunoendocrine conditions, such as stress, perimenopause, chronic inflammation, obesity, and chronic dizziness. The model suggests that critical targets for FM treatment are to be found among immunoendocrine pathways leading to GABA/glutamate imbalance having an impact on the thalamocortical system.
“…В недавнем кросс-секционном исследовании с участием 485 женщин 35-78 лет в постменопаузе факторами риска развития депрессии у женщин в постменопаузе были признаны смерть партнера или развод; употребление алкоголя; любое заболевание, требующее постоянного приема лекарственных препаратов; наличие каких-либо физических недостатков; психические расстройства в анамнезе, а также, что интересно, совместное проживание с 4 и более детьми [34].…”
Surgical and natural menopause is often associated with depression symptoms. Along with the postpartum period, perimenopause is a “window of vulnerability” for depression development, because decline in estrogen level accounts for extinction of reproductive function, emotional disorders, genitourinary menopausal syndrome, which are combined with non-endocrine risk factors, such as decreasing income levels, low social support, and stress. Although a direct relationship between blood estrogens level and depression has not been demonstrated, the relation between menopause symptoms and depression has been proven, i.e., the symptoms of menopause can be considered as risk factors. Here, we summarizes the current view on the correct counseling and routing of menopausal women with depression symptoms in primary health care facilities, the principles of managing patients with risk factors, including genitourinary menopausal syndrome, as well as methods of rehabilitation and informational support. This will aid to improve the quality of medical care for such patients.
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