Depression, anxiety and associated factors among people with epilepsy and attending outpatient treatment at primary public hospitals in northwest Ethiopia: A multicenter cross-sectional study

Nigussie, Kabtamu; Lemma, Alemu; Sertsu, Addisu; Asfaw, Henock; Kerebih, Habtamu; Abdeta, Tilahun

doi:10.1371/journal.pone.0256236

Cited by 13 publications

(12 citation statements)

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“…In general, high-risk and frequent exacerbation patients need to change medication or polypharmacy, which often causes adverse effects both physical and psychological ( 38 , 39 ). Moreover, patients with polypharmacy are not only prone to psychological comorbidities such as anxiety and depression ( 40 ), but also increase the risk of drug interactions and long-term drug toxicity ( 41 ). Compared to healthy people, epilepsy patients require long-term AEDs treatment in combination with other drugs, resulting in higher economic and physical burdens ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Self-perceived burden and associated factors in Chinese adult epilepsy patients: A cross-sectional study

Tang

Birong

et al. 2022

Front. Neurol.

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ObjectivesEpilepsy requires long-term or lifelong treatment, and patients are prone to financial, emotional and psychological burdens that can cause psychological changes during the treatment process. This study aimed to describe the prevalence and associated factors of Self-Perceived Burden (SPB) in Chinese adult epilepsy patients, informing the treatment and nursing of epilepsy.MethodsA total of 143 adult epilepsy patients were included in this study, and the clinical questionnaire survey was conducted at the Third Xiangya Hospital of Central South University in Hunan, China, from March 2022 to June 2022. The sociodemographic and clinical characteristics of adult epilepsy patients were collected using a self-developed questionnaire, and the data on SPB, stigma and quality of life were collected through the Self-Perceived Burden Scale (SPBS), Kilifi Stigma Scale for Epilepsy (KSSE) and Quality of Life in Epilepsy Inventory-31 (QOLIE-31). Multiple linear regression analysis was used to determine the associated factors influencing SPB in adult epilepsy patients.ResultsThe average score of SPBS for the 143 adult epilepsy patients was 30.77 (SD = 9.06), and 89.5% of them had obvious SPB. The results of the univariate analysis showed that residence, monthly household income, duration of epilepsy, type of medication and electroencephalogram finding were associated with SPB (P < 0.05). In Spearman correlation analysis indicated that SPBS score were positively correlated with KSSE score (r = 0.510, P < 0.05) while negatively correlated with QOLIE-31 score (r = −0.506, P < 0.05). Multiple linear regression analysis revealed that factors such as KSSE, type of medication, residence and electroencephalogram finding accounted for 32.8% of the factors influencing SPB in adult epilepsy patients.Conclusion89.5% of adult epilepsy patients have varying degrees of SPB, which is associated with high stigma and poor quality of life. Therefore, during the treatment and nursing of adult epilepsy patients, clinical staff should pay attention to the psychological status of patients, help them reduce their psychological burden, and guide them to develop a healthy lifestyle.

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Section: Discussionmentioning

confidence: 99%

Self-perceived burden and associated factors in Chinese adult epilepsy patients: A cross-sectional study

Tang

Birong

et al. 2022

Front. Neurol.

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“…However, there is observed variability in the prevalence of these mental disorders among PWE across the world [ 9 ]. For example, a high prevalence of depression and anxiety was reported in the United Arab Emirates (26.9% and 25.8%), China (52.6% and 33.4%), Brazil (24.4% and 39.4%), Thailand (20% and 39%), Iran (9.5% and 24.5%), USA (26.9% and 25.8%), and Canada (17.4% and 22.8%) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…PWE experience various difficulties that may trigger emotional burdens, such as loss of control in life due to unexpected seizures, diminished disease adaptation, and limited quality of life [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Anxiety and Depression in Persons With Epilepsy (PWE)

Roussos,

Gerogianni,

Vasilopoulos

et al. 2024

Cureus

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Introduction: Epilepsy is a common neurological disease that is associated with increased morbidity and mortality globally. Persons with epilepsy (PWE) experience a heavy emotional burden mainly due to social stigmatization and limited opportunities in life. The purpose of this study was to explore factors associated with anxiety and depression in PWE. Material and methods: In the present cross-sectional study, we enrolled 100 PWE who visited outpatient settings in a public hospital for scheduled follow-up. Data collection was carried out by the completion of the Hospital Anxiety and Depression Scale (HADS), which included participants’ characteristics. The statistical significance level was p < 0.05. Results: Of the 100 participants, the majority were women (65%), below 50 years old (62%), and single (40%). In terms of mental comorbidity, 58% and 48% experienced anxiety and depression, respectively. A statistically significant association was observed between anxiety and age (p = 0.002). Furthermore, a statistically significant association was observed between depression and gender (p = 0.044), age (p = 0.001), marital status (p = 0.036), educational level (p = 0.003), job (p = 0.025), residency (p = 0.041), and whether they went out at night (p = 0.009). Conclusion: Identifying factors associated with anxiety and depression is essential for PWE to receive appropriate support.

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“…An estimated 5 million people in Sub-Saharan Africa have epilepsy [1]. One third of people living with epilepsy (PLWE) in Sub-Saharan Africa experience depression [2], and over one third experience anxiety [3]; in comparison, the estimated prevalence in PLWE overall is 9%-37% for depression and 11%-25% for anxiety [4]. Cross-sectional studies from multiple Sub-Saharan African countries have shown that the prevalence of depressive symptoms is high in PLWE, ranging from 40% (Ethiopia) to 86% (East Nigeria) [2].…”

Section: Introductionmentioning

confidence: 99%

Impact of a free medication intervention on seizure recurrence and anxious and depressive symptoms in people living with epilepsy in the Republic of Guinea

Rice,

Guelngar,

Traoré

et al. 2023

Tropical Med Int Health

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Background and ObjectiveOf ~5 million people living with epilepsy (PLWE) in Sub‐Saharan Africa, roughly one‐third experience depression and over one third experience anxiety. In Guinea, these issues may be compounded by fewer available resources, such as appropriate anti‐seizure medications (ASMs). We aim to quantify seizure frequency, anxiety and depression in PLWE in Guinea, before and after a free ASM intervention and neurologist's consultation.MethodsGuinean participants >12 years old with ≥2 unprovoked seizure were prospectively recruited. As part of a broader interview, participants reported prior 30‐day seizure frequency and screened for depression (PHQ‐9) (range 0–27 points) and anxiety (GAD‐7) (range 0–21 points) with re‐evaluation at 90 days.ResultsOf 148 participants enrolled (mean age = 27.3 years, range 12–72; 45% female), 62% were currently taking ASMs. For the 30 days pre‐enrolment, average seizure frequency was 3.2 (95%CI 2.3, 4.2); 28% of participants were seizure‐free. ASM regimens were modified for 95% of participants, mostly initiating levetiracetam (n = 115, 80% of modifications). 90‐day study retention was 76% (n = 113) among whom 87% reported full adherence to the ASM. After 90 days, the average seizure frequency over the prior 30 days was 1.5 (95%CI 0.5, 2.6), significantly lower than at baseline (p = 0.002). 66% were seizure‐free.At baseline, average PHQ‐9 score was 21.2 (95%CI [20.2, 22.2]), indicating severe depressive symptoms. Average GAD‐7 score was 16.5 [15.6, 17.4], indicating severe anxious symptoms. At 90‐days, average PHQ‐9 score was 17.5[16.4, 18.5] and significantly lower than baseline (p < 0.001). Average GAD‐7 score was 14.4 [13.6, 15.3] and significantly lower than baseline (p = 0.002). Seizure frequency was not correlated with PHQ‐9 nor GAD‐7 scores at baseline but was at 90 days for both PHQ‐9 (r = 0.24, p = 0.01) and GAD‐7 (r = 0.22, p = 0.02) scores. The prevalence of suicidal ideation dropped from 67% to 47% of participants (p = 0.004).DiscussionASM management has dual importance for PLWE in resource‐limited settings, improving both seizure control and mental health.

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Depression, anxiety and associated factors among people with epilepsy and attending outpatient treatment at primary public hospitals in northwest Ethiopia: A multicenter cross-sectional study

Cited by 13 publications

References 30 publications

Self-perceived burden and associated factors in Chinese adult epilepsy patients: A cross-sectional study

Self-perceived burden and associated factors in Chinese adult epilepsy patients: A cross-sectional study

Factors Associated With Anxiety and Depression in Persons With Epilepsy (PWE)

Impact of a free medication intervention on seizure recurrence and anxious and depressive symptoms in people living with epilepsy in the Republic of Guinea

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